Induction of genomic instability after an acute whole-body exposure of mice to Fe ions

The purpose of this study was to evaluate dose–response relationships for the in vivo induction of micronuclei (MN) as a measure of both initial radiation damage and the induction of genomic instability. These measurements were made in mouse blood erythrocytes as a function of radiation dose, radiation quality, time after irradiation, and the genetic background of exposed individuals. Blood samples were collected from two strains of mouse (CBA/CaJ and C57BL/6J) at different times up to 3 months following a whole-body exposure to various doses of 1 GeV/amu ⁵⁶Fe ions (0, 0.1, 0.5 and 1.0 Gy, at the dose rate of a 1 Gy/min) or ¹³⁷Cs gamma rays (0, 0.5, 1.0 and 3.0 Gy, at the dose rate of 0.72 Gy/min). Blood-smear slides were stained with acridine orange (AO). The frequencies of MN were measured in mature normochromatic-erythrocytes (MN-NCEs) and in immature polychromatic-erythrocytes (MN-PCEs). Effects of both types of radiation on erythropoiesis were also evaluated. As a measure of cell progression delay, a dose-dependent decrease in numbers of PCEs was observed at day 2 post-exposure in both strains, regardless of radiation quality. Subsequently, the levels of PCEs increased in all exposed mice, reaching control levels (or higher) by day 7 post-exposure. Further, at day 2 after the exposure, there was no increase in the frequency of MN-PCEs in CBA/CaJ mice exposed to ⁵⁶Fe ions while the frequency of MN-PCEs elevated as a function of dose in the C57BL/6J mice. At day 4, there was no dose related increase in MN-NCEs in either strain of mouse exposed to ¹³⁷Cs gamma rays. Additionally, at the early sacrifice times (days 2 and 4), ⁵⁶Fe ions were slightly more effective (per unit dose) in inducing MN-NCEs than ¹³⁷Cs gamma rays in CBA/CaJ mice. However, there was no increase in the frequency of MN-NCEs at late times after an acute exposure to either type of radiation. In contrast, both types of radiation induced increased MN-PCEs frequencies in irradiated CBA/CaJ mice, but not C57BL/6J mice, at late times post-exposure. This finding indicates the potential induction of genomic instability in hematopoietic cells of CBA/CaJ mice by both types of radiation. The finding also demonstrates the influence of genetic background on radiation-induced genomic instability in vivo.     

影响PCL系统探测性能的因素分析

给出了可选作无源探测系统辐射源的信号参数,分析了目标的双基地等效反射面积、接收机噪声系数、干扰电平的组成及其相应的处理方法、PCL系统有效带宽和积累增益的关系,并对PCL系统的灵敏度和覆盖范围进行了研究.以此为基础,重新推导了双基地无源探测的距离方程.最后通过仿真分析了PCL系统可以获得的性能及其关键确定因素.     

Human response to high-background radiation environments on Earth and in space

The main long-term objective of the space exploration program is the colonization of the planets of the Solar System. The high cosmic radiation equivalent dose rate represents an inescapable problem for the safe establishment of permanent human settlements on these planets. The unshielded equivalent dose rate on Mars ranges between 100 and 200 mSv/year, depending on the Solar cycle and altitude, and can reach values as high as 360 mSv/year on the Moon. The average annual effective dose on Earth is about 3 mSv, nearly 85% of which comes from natural background radiation, reduced to less than 1 mSv if man-made sources and the internal exposure to Rn daughters are excluded. However, some areas on Earth display anomalously high levels of background radiation, as is the case with thorium-rich monazite bearing sand deposits where values 200–400 times higher than the world average can be found. About 2% of the world’s population live above 3 km and receive a disproportionate 10% of the annual effective collective dose due to cosmic radiation, with a net contribution to effective dose by the neutron component which is 3–4 fold that at sea level. Thus far, epidemiological studies have failed to show any adverse health effects in the populations living in these terrestrial high-background radiation areas (HBRA), which provide an unique opportunity to study the health implications of an environment that, as closely as possibly achievable on Earth, resembles the chronic exposure of future space colonists to higher-than-normal levels of ionizing radiation. Chromosomal aberrations in the peripheral blood lymphocytes from the HBRA residents have been measured in several studies because chromosomal damage represents an early biomarker of cancer risk. Similar cytogenetic studies have been recently performed in a cohort of astronauts involved in single or repeated space flights over many years. The cytogenetic findings in populations exposed to high dose-rate background radiation on Earth or in space will be discussed.     

Relation between galactic and solar cosmic radiation at aviation altitude

Cosmic radiation bombards us at high altitude with ionizing particles; the radiation has a galactic component, which is normally dominant, and a component of solar origin. Cosmic ray particles are the primary source of ionization in the atmosphere above 1 km; below 1 km radon is a dominant source of ionization in many areas.     

高超声速钝锥模型及其尾迹红外辐射实验研究

介绍了利用InSb红外辐射计在弹道靶上测量底部直径为10mm、半锥角和头部半径分别为9°、2.2mm(模型A),8°、0.6mm(模型B)的两种非烧蚀钝锥模型及其尾迹的红外辐射.模型速度大于6km/s,飞行环境压力约4.8kPa,红外辐射测量波段为1~3μm、3~5μm.结果表明:非烧蚀钝锥模型头身部红外辐射远大于尾迹红外辐射,在相同飞行速度和环境压力条件下,模型A产生的红外辐射比模型B产生的红外辐射强.     

浮动壁火焰筒壁温试验和计算分析

对某浮动壁火焰筒的壁温进行了试验和计算分析。该火焰筒应用了新型的浮动壁结构和高效的冲击/发散复合冷却技术。壁温分布试验在全环形燃烧室试验台上进行,采用热电偶和示温漆测量。计算采用了稳态导热问题的有限元求解方法。研究分析表明,火焰筒壁温在材料的长期许用温度范围内,壁温计算反映了火焰筒壁温的分布规律和趋势。冲击/发散复合冷却方式的轴向壁温梯度小于缝槽气膜冷却方式,对降低热应力水平,延长火焰筒使用寿命有利。     

配置点谱方法求解非均匀介质内辐射传热问题

发动机内的燃气等高温介质随着组分和浓度的变化，会引起折射率在空间上的非均匀分布，从而导致辐射能束沿着曲线传播，其相应的辐射传热过程也更为复杂。为了避免射线追踪方法的复杂计算、提高计算效率，本文提出了配置点谱方法求解二维非均匀介质内辐射传热问题。在求解过程中，角向采用离散坐标法处理，空间采用配置点谱方法处理。通过将三种非均匀介质内辐射传热问题的配置点谱方法结果与文献结果进行对比分析，发现配置点谱方法可以在较少的节点数下，获得准确、有效地计算结果。并且，采用配置点谱方法求解三种算例的计算时间均消耗较少，均在20分钟以内。这将为进一步开展发动机复杂结构内高温燃气辐射快速仿真提供基础。     

Observations of the local interstellar medium with the Extreme Ultraviolet Explorer

Because of the strong absorption of extreme ultraviolet radiation by hydrogen and helium, almost every observation with the Extreme Ultraviolet Explorer (EUVE) satellite is affected by the diffuse clouds of neutral gas in the local interstellar medium (LISM). This paper reviews some of the highlights of the EUVE results on the distribution and physical state of the LISM and the implications of these results with respect to the interface of the LISM and the heliosphere. The distribution of sources found with the EUVE all-sky surveys shows an enhancement in absorption toward the galactic center. Individual spectra toward nearby continuum sources provide evidence of a greater ionization of helium than hydrogen in the Local Cloud with an mean ratio of H I/He I of 14.7. The spectral distribution of the EUV stellar radiation field has been measured, which provides a lower limit to local H II and He II densities, but this radiation field alone cannot explain the local helium ionization. A combination of EUVE measurements of H I, He I, and He II columns plus the measurement of the local He I density with interplanetary probes can place constraints on the local values of the H I density outside the heliosphere to lie between 0.15 and 0.34 cm^–3 while the H II density ranges between 0.0 and 0.14 cm^–3. The thermal pressure (P/k = nT) of the Local Cloud is derived to be between 1700 and 2300 cm^–3 K, a factor of 2 to 3 above previous estimates.     

Self-similar neutrino heat waves

Transport of energy and lepton charge by neutrino radiation in a uniform medium is investigated within neutrino-thermoconductivity approximation — as a neutrino heat wave. The process is described by a self-similar solution. The problem applies primarily to the cooling of young neutron stars.     

The infra-red background generated by pregalactic stars and their remnants

We examine whether the IR background reported by Matsumoto (1983) could have been generated by stars or black holes in the pregalactic era, z=10100.