排序方式: 共有26条查询结果,搜索用时 15 毫秒
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Shane A.J. Lloyd Eric R. Bandstra Neil D. Travis Gregory A. Nelson J. Daniel Bourland Michael J. Pecaut Daila S. Gridley Jeffrey S. Willey Ted A. Bateman 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008
Extended exposure to microgravity conditions results in significant bone loss. Coupled with radiation exposure, this phenomenon may place astronauts at a greater risk for mission-critical fractures. In a previous study, we identified a profound and prolonged loss of trabecular bone (29–39%) in mice following exposure to an acute, 2 Gy dose of radiation simulating both solar and cosmic sources. However, because skeletal strength depends on trabecular and cortical bone, accurate assessment of strength requires analysis of both bone compartments. The objective of the present study was to examine various properties of cortical bone in mice following exposure to multiple types of spaceflight-relevant radiation. Nine-week old, female C57BL/6 mice were sacrificed 110 days after exposure to a single, whole body, 2 Gy dose of gamma, proton, carbon, or iron radiation. Femora were evaluated with biomechanical testing, microcomputed tomography, quantitative histomorphometry, percent mineral content, and micro-hardness analysis. Compared to non-irradiated controls, there were significant differences compared to carbon or iron radiation for only fracture force, medullary area and mineral content. A greater differential effect based on linear energy transfer (LET) level may be present: high-LET (carbon or iron) particle irradiation was associated with a decline in structural properties (maximum force, fracture force, medullary area, and cortical porosity) and mineral composition compared to low-LET radiation (gamma and proton). Bone loss following irradiation appears to be largely specific to trabecular bone and may indicate unique biological microenvironments and microdosimetry conditions. However, the limited time points examined and non-haversian skeletal structure of the mice employed highlight the need for further investigation. 相似文献
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Studies on urine treatment by biological purification using Azolla and UV photocatalytic oxidation 总被引:1,自引:0,他引:1
Xiaofeng Liu Min Chen Zuliang Bian Chung-chu Liu 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(5):783-786
The amount of water consumed in space station operations is very large. In order to reduce the amount of water which must be resupplied from Earth, the space station needs to resolve the problems of water supply. For this reason, the recovery, regeneration and utilization of urine of astronauts are of key importance. Many investigations on this subject have been reported. Our research is based on biological absorption and, purification using UV photocatalytic oxidation techniques to achieve comprehensive treatment for urine. In the treatment apparatus we created, the urine solution is used as part of the nutrient solution for the biological components in our bioregenerative life support system. After being absorbed, the nutrients from the urine were then decomposed, metabolized and purified which creates a favorable condition for the follow-up oxidation treatment by UV photocatalytic oxidation. After these two processes, the treated urine solution reached Chinese national standards for drinking water quality (GB5749-1985). 相似文献
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免疫应答反应一直是限制可植入生物材料应用的关键因素之一。实验评估了2种用于骨修复的胶原膜在体内的免疫反应,希望为其临床试验提供依据。在将2种膜皮下植入到BALB/c小鼠后的第14天,与阴性对照(NC,未植入材料)相比,脾和淋巴结没有明显肿大,淋巴结细胞数几乎没差异,而脾细胞数大约是NC的2倍。流式细胞术分析显示植入胶原膜1导致脾中T细胞比例减少了约13%,但是没有影响T细胞亚群,而植入胶原膜2对小鼠的脾细胞组成没有明显影响;2种胶原膜都激活了一定的B细胞,激活率大约为NC小鼠的2倍。淋巴细胞体外增殖实验显示与NC组无显著差异。酶联免疫吸附测试表明胶原膜1导致了第14天血清中的抗体浓度升高至NC小鼠的2倍。局部H&E染色显示2种材料都引起了轻微的细胞浸润。这2种胶原膜引起的免疫反应很微弱,可以被应用于临床试验。 相似文献
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松质骨微观骨小梁结构的生物力学综合分析 总被引:1,自引:0,他引:1
股骨松质骨具有骨小梁的微观结构特性,影响了股骨的整体力学性能,找到适当的单元形状与骨小梁分布特点可以有效地进行股骨生物力学特性分析.采用不同结构的微观骨小梁单元模型分析各单元的生物力学特性,并采用快速成形样件力学实验和有限元分析相结合的方法,对由不同骨小梁单元及不同分布形式构成的股骨模型进行生物力学分析,找到了较好的微观骨小梁单元模型及总体布局形式,获得了快速成形样件实验分析与有限元分析2种结果的综合分析,并应用于股骨松质骨建模.所获得的微观单元优化结构可以有效地应用于仿生结构材料的制造. 相似文献
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以太阳扇(Scaevola aemula)嫩叶、老叶、茎段、茎节为材料进行外植体筛选;以太阳扇嫩叶为外植体,研究愈伤组织诱导、不定芽分化及增殖、生根培养的适宜条件.结果表明:嫩叶为太阳扇愈伤组织诱导最佳外植体;MS+6-BA 0.50mg/L+2,4-D 0.20mg/L为愈伤组织诱导最佳培养基;MS+6-BA 0.50mg/L+NAA 0.10mg/L为芽分化最佳培养基,分化率可达96.5%;1/2MS+NAA 0.01mg/L为芽增殖最佳培养基,增殖系数最高可达3.33;糖浓度、NAA均影响太阳扇无菌苗生根,1/2MS+NAA 0.02mg/L+蔗糖30g/L为生根培养最适培养基;g腐殖质∶g珍珠岩∶g细土=2∶1∶1为组培苗移栽最佳基质,移栽成活率达75%. 相似文献
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郭辛欣 《北华航天工业学院学报》2012,22(5):3-5,9
在城市快速发展过程中,城市更新作为城市改造、再生和复兴的重要手段,逐渐受到地方政府和专业技术人员的关注。当前城市更新过程中普遍存在简单化清除的现象,居民需求和城市历史文脉的延续之间存在明显的矛盾,遗产保护在城市更新中受到很大的负面影响。本文通过对英国和台湾城市更新中遗产保护经验的总结和归纳,为我国发展遗产保护引导型的城市更新提供有效适用的参考和借鉴。 相似文献
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