Protective effects of melatonin against C beam irradiation-induced oxidative stress and DNA injury in the mouse brain

The purpose of this experiment was to estimate the protective effects of melatonin against radiation-induced brain damages in mice induced by heavy ion beams. Kun-Ming mice were randomly divided into five groups: normal control group, irradiation control group, and three different doses of melatonin (5, 10, and 20 mg/kg, i.p.) treated groups. Apart from the normal control group, the other four groups were exposed to whole-body 4.0 Gy carbon ion beam irradiation (approximately 0.5 Gy/min) after i.p. administration of normal saline or melatonin 1 h before irradiation. The oxidative redox status of brain tissue was assessed by measurement of malondiadehyde (MDA) levels, total superoxide dismutase (T-SOD), cytosolic superoxide dismutase (Cu/ZnSOD, SOD1) and mitochondrial superoxide dismutase (MnSOD, SOD2) activities at 8 h after irradiation. DNA damages were determined using the Comet assay and apoptosis and cell cycle distribution were detected by flow cytometric analyses. A dramatic dose-dependent decrease in MDA levels, tail moment, rates of tailing cells, and apoptosis, and a dose-dependent increase in T-SOD and SOD2 activities, in brain tissues in the melatonin-treated groups were detected compared with the irradiation only group. Furthermore, flow cytometric analysis demonstrated that the percentage of brain cells in the G0/G1 phase decreased significantly, while those in the S and G2/M stage increased dramatically, with mice pretreated with melatonin compared to the irradiation control group. These data indicate that melatonin has protective effects against irradiation-induced brain injury, and that its underlying protective mechanisms may relate to modulation of oxidative stress induced by heavy ionirradiation.     

A new online modelling method for aircraft engine state space model

To overcome the drawbacks of current modelling method for aircraft engine state space model, a new method is introduced. The form of state space model is derived by using Talyor series to expand the nonlinear model that is implicit equations and involves many iterations. A partial derivative calculation method for iterations is developed to handle the influence of iterations on parameters. The derivative calculation and the aerothermodynamics calculations are combined in the component level model with fixed number Newton-Raphson (N-R) iterations. Mathematical derivation and simulations show the convergence ability of proposed method. Simulations show that comparing with the linear parameter varying model and centered difference based state space model, much higher accuracy of proposed online modelling method is achieved. The accuracy of the state space model built by proposed method can be maintained when the step amplitudes of inputs are within 2%, and the responses of the state space model can match those of the component level model when each input steps larger amplitudes. In addition, an online verification was carried out to show the capability of modelling at any operating point and that state space model can predict future outputs accurately. Thus, the effectiveness of the proposed method is demonstrated.     

三层三级民机修理级别经济性分析模型的改进

现代民机产品普遍采用模块化设计，具有多层次特点，相应的维修场所也表现为多个维修级别。现有修理级别分析（LORA）模型在移级维修和报废时，可能存在父单元与其内部封装子单元成本重复累加的问题。引入跟随行为矩阵，对子单元中因父单元层级约束而做出的决策进行标记，能有效地避免父单元与子单元成本被重复计算。在此基础上，考虑实际维修活动中无故障发现事件（NFF）、二次维修等人为因素对LORA决策的影响，建立适用于民机的修理级别分析模型，较已有模型更加真实地反映决策的预计成本，提高了决策的可信度和工程适用性。最后使用混合惩罚函数法将原问题转化为等价的无约束优化问题，采用改进的二进制粒子群算法（BPSO）对多故障模式下的三层三级案例进行仿真优化，验证了该经济性分析模型的合理性和求解算法的有效性。     

Multi- GNSS reflectometry performance evaluation for coastal sea level monitoring: A case study in Antarctic Peninsula

Antarctica is a continent that crucial for studying climate change and its progression across time, as well as analyzing and forecasting local and global change. In this environment, due to the challenges caused by sea-level rise, storm surges, and tsunamis, sustainability is a critical concern, particularly for coastal regions. As a result, the long-term observations that will be conducted in Antarctica are critical for monitoring the adverse impacts of climate change. In recent years, many monitoring approaches, both space, and ground-based are performed to monitor sea/ice level trends in space-based scientific investigations conducted in and around the region. In the study, based on one year of observations from the Palmer GNSS Station, the GNSS Reflectometry technique was used to measure the sea level on the Antarctic Peninsula (PALM). GNSS Station observations were analyzed with a Lomb-Scargle periodogram to monitor sea-level changes, and results were validated with data from a co-located tide gauge (TG). The results show that the correlation between GNSS-R sea-level changes and tidal sea-level changes is found as 0.91.     

剥蚀对含孔试件疲劳寿命影响研究

剥蚀是影响老龄飞机结构完整性的重要因素之一。本文对LY12CZ铝合金含孔试件进行了预剥蚀疲劳试验,试验结果表明剥蚀使疲劳寿命下降,但其与剥蚀程度并不成正比。运用MSC.Marc中的单元"软化"技术模拟了剥蚀对试件应力分布影响,结果表明最大主应力不但与腐蚀深度有关,还与腐蚀形貌和位置有关。最后基于材料的初始不连续状态(initial discontinuity state,IDS),建立了评估剥蚀对含孔试件疲劳寿命影响的模型。预测值与试验结果比较表明,该模型预测结果精确,方法可靠。     

榫连结构的高应力梯度及破坏分析

某燕尾形榫连结构的分析表明叶盘榫齿/榫槽接触区边缘存在较高的应力梯度,接触应力的有限元解同网格疏密程度密切相关.通过建立一系列不同密度网格的模型,对此问题展开有限元建模分析,以改善接触应力的求解精度,同时深入讨论材料弹塑性对接触应力的影响.在弹塑性接触应力分析的基础上,采用断裂力学方法建立了榫连结构高应力梯度位置的破坏分析模型,判断裂纹的萌生及扩展方向,以进行结构的强度及寿命分析.     

基于原子内聚力与表面能等效的内聚裂纹模型

 从非局部连续介质理论出发,采用一种新的理性力学方法对裂纹前缘内聚应力分布规律进行研究。首先,在内聚裂纹表面引入非局部应力边界条件,从而将内聚区内表面诱发张力(非局部表面残余)与内聚应力等价联系起来;然后,利用能量平衡关系,得到仅与表面能密度相关的I型裂纹内聚力新的本构方程。最后,在推导结果的基础上,计算一个具体的脆性断裂算例研究内聚区内表面能与内聚应力随裂纹张开位移(COD)变化的分布规律。由计算结果发现,裂纹尖端应力奇异性消除,且应力最大值不一定出现在裂纹尖端,而是发生在裂纹尖端周围的内聚区内。     

广布损伤的试验研究与有限元分析

 通过对无钉载3排平行孔平板和无钉载3排交错孔平板从无裂纹开始的疲劳试验,发现应力大小对是否出现广布损伤(MSD)有重要影响,首裂孔和断裂排位不总是一一对应。在试验中观察到了MSD的竞争现象,证实了群发小裂纹也是MSD中一种重要的破坏形式。采用FRANC2D/L建立了对生裂纹、非对生裂纹和单裂纹3种开裂模式的有限元模型。计算结果表明:短裂纹扩展过程中,裂纹间干涉效应不明显,3种模式的应力强度因子增长趋势相近;而对于长裂纹,试验和有限元计算都证明了裂纹间的干涉显著地加快了裂纹的扩展。     

基于CNS定位误差的平行航路间隔安全评估

主要对平行航路中基于CNS定位误差的飞行间隔安全评估问题进行了研究。首先分析了CNS定位误差对飞机碰撞风险的影响。其次运用概率论方法得到了CNS定位误差下飞机纵向、侧向和垂直三个方向上的碰撞风险计算模型,并根据模型利用牛顿迭代算法,通过给定某一方向安全目标水平计算CNS定位误差下相应的安全间隔。最后对平行航路三个方向的飞行间隔进行了评估计算,将结果与实际相比较,表明该模型可行。     

TA15钛合金薄板等离子弧对接焊缝疲劳特性研究

为了探索钛合金等离子弧焊接头的疲劳性能,本文依据TA15标准试件和轧制板材试件疲劳试验数据处理结果,采用当量应力集中系数法,在TA15薄板等离子弧焊和对接焊缝磨削组合工艺试件的疲劳试验基础上,确定了中值当量应力集中系数和安全当量应力集中系数,最后建立了该TA15薄板的S-N曲线,给出了应用结论。