Induction of genomic instability after an acute whole-body exposure of mice to Fe ions

The purpose of this study was to evaluate dose–response relationships for the in vivo induction of micronuclei (MN) as a measure of both initial radiation damage and the induction of genomic instability. These measurements were made in mouse blood erythrocytes as a function of radiation dose, radiation quality, time after irradiation, and the genetic background of exposed individuals. Blood samples were collected from two strains of mouse (CBA/CaJ and C57BL/6J) at different times up to 3 months following a whole-body exposure to various doses of 1 GeV/amu ⁵⁶Fe ions (0, 0.1, 0.5 and 1.0 Gy, at the dose rate of a 1 Gy/min) or ¹³⁷Cs gamma rays (0, 0.5, 1.0 and 3.0 Gy, at the dose rate of 0.72 Gy/min). Blood-smear slides were stained with acridine orange (AO). The frequencies of MN were measured in mature normochromatic-erythrocytes (MN-NCEs) and in immature polychromatic-erythrocytes (MN-PCEs). Effects of both types of radiation on erythropoiesis were also evaluated. As a measure of cell progression delay, a dose-dependent decrease in numbers of PCEs was observed at day 2 post-exposure in both strains, regardless of radiation quality. Subsequently, the levels of PCEs increased in all exposed mice, reaching control levels (or higher) by day 7 post-exposure. Further, at day 2 after the exposure, there was no increase in the frequency of MN-PCEs in CBA/CaJ mice exposed to ⁵⁶Fe ions while the frequency of MN-PCEs elevated as a function of dose in the C57BL/6J mice. At day 4, there was no dose related increase in MN-NCEs in either strain of mouse exposed to ¹³⁷Cs gamma rays. Additionally, at the early sacrifice times (days 2 and 4), ⁵⁶Fe ions were slightly more effective (per unit dose) in inducing MN-NCEs than ¹³⁷Cs gamma rays in CBA/CaJ mice. However, there was no increase in the frequency of MN-NCEs at late times after an acute exposure to either type of radiation. In contrast, both types of radiation induced increased MN-PCEs frequencies in irradiated CBA/CaJ mice, but not C57BL/6J mice, at late times post-exposure. This finding indicates the potential induction of genomic instability in hematopoietic cells of CBA/CaJ mice by both types of radiation. The finding also demonstrates the influence of genetic background on radiation-induced genomic instability in vivo.     

改进整体传递矩阵法计算复杂转子系统临界转速

提出了一种基于整体传递矩阵法的改进传递矩阵法。新方法将Riccati变换及奇点消除方法应用于整体传递矩阵方程,导出了耦合单元和非耦合单元的Riccati传递矩阵计算公式。这种方法克服了传统传递矩阵法的缺点,易于开发通用计算程序。文末给出了数值算例,计算结果表明了该方法的有效性和正确性。      

Numerical Simulation for the 16 August 1999 EUV Brightenings

The 16 August 1999 EUV brightenings are numerically simulated by a third-order upwind compact scheme, basing on the TRACE observation. The present simulation can give a possible explanation to its formation and evolution. The numerical results show that the initial reconnection jets at around X-point are responsible for the occurrence of EUV brightening. The strong and superposed ejections caused by the first and second coalescence of magnetic islands are possibly related to the lifted material which initially appeared as absorption features and Later EUV-emitting structures respectively. The bi-directional reconnection jets may correspond to the lifted material that either continued to move upward along the apparently open field lines or fell down to the surface.      

流量转速参数信号调理技术

液体火箭发动机试验中,流量和转速传感器输出的信号为不规则的频率信号,对不规则频率信号的调理是准确测量的关键环节。介绍了液氧煤油发动机地面试验中流量和转速参数信号的调理技术,重点阐述频率信号调理器的原理、功能、设计要点及调试方法,给出了频率信号调理器的关键环节原理图。使用这种频率信号调理器对液氧煤油发动机试验中流量和转速传感器输出的频率信号直接进行调理,保证了频率型参数的准确测量。     

数控加工运动的平滑处理

为了满足高速加工的要求,提出假设圆弧过渡法来处理两相邻运动矢量拐角处的速度,过渡小圆弧的半径能随加工精度的变化而自动地调整,通过限制加工小圆弧的最大速度来限制拐角处的速度,利用超前分析的方法,根据减速所需的最大距离提出了一种多程序段运动平滑算法,实现进给速度提前减速,从而防止刀具在拐角处发生过载,并有效地减少了工件形状在拐角处,或小半径圆弧的加工误差;用等效的梯形加减速方法实现了S型曲线加减速的分析,导出了S型曲线加减速实时精确的插补算法,从而克服了用查表法来近似计算速度的缺点。这些算法简单、有效,已在最新开发的高速铣床上得到应用。在高速加工时获得了高的加工精度。     

赤道地区和中纬度地区扩展F的特点和比较

通过数值模拟研究了赤道地区和中纬度地区扩展F的触发机制间的联系,发现相同的触发机制在不同纬度的条件下所演化出的结构形态不相同,因此观测上会有所不同;研究了西向电场在赤道地区的作用,发现在适合的电离层参数组合下会产生观测到的电离层F区顶部扰动出现率高于底部扰动出现率的状况;在数值模拟的基础上提出了一个中纬度地区电波散射的模型,用以解释观测到的中纬度地区电波散射的出现率高于线性理论预期的现象.      

涡轮泵转子的临界转速研究(Ⅳ)分布质量轴的传递矩阵法

根据旋转的 Timoskenko梁的运动微分方程式 ,导出分布质量轴段的 4× 4阶精确传递矩阵 ,计入轴分布质量的平动惯量、转动惯量、陀螺力矩和剪切变形的影响 ,并计算了三个转子的临界转速。算例的计算结果表明 ,轴模型是否按分布质量考虑、是否计入平动惯量、转动惯量、陀螺力矩和剪切变形 ,对临界转速有明显的差别 ;同时在等截面轴不分段情况下 ,传递矩阵的计算结果和精确解一致性很好 ,表明计算实际转轴临界转速时 ,只需按截面不同划分轴段 ,即所取的轴分段数量少 ,就可以达到很高的计算精度     

速度调整在空中交通管制中的应用

介绍了航空器有关速度调整（简称调速）的部分性能原理－－调速的基础,又以中国民航、国际民航组织、美国联帮航空局所颁布的规章条例为依据,对目前中国空中交通管制员在提供管制服务时所采用的调速方法及原因的合理性进行了分析,并以Ｂ７３７－３００为例具体说明各种情况下调速范围的选择,最后,提出了笔者的一些观点。     

GPS速度法确定飞机空速系统位置误差

飞机空速系统位置误差的测定,飞行试验中有多种常规方法,但期精度只能满足常规型号空速系统的验证要求。针对这一问题提出了ＧＰＳ速度法,叙述了该方法的原理、实施过程和数据处理方法,讨论了方法的系统精度并给出了误差估算结果。通过对某型飞机的验证试飞,表明该方法简便易行,可满足气动补偿型空速系统的试飞验证要求。     

速度脉动下分层旋流火焰动态传播结构提取

为了深刻理解分层旋流火焰的动态结构,开展了分层旋流火焰动态的模态分析和参数化研究.实验在BASIS(北京航空航天大学发展的具有台阶隔离段的独立分层旋流燃烧器)上开展,以甲烷为燃料预混燃烧,使用高速摄像捕捉了速度脉动下的CH*化学发光信号动态图像.利用传统的本征正交分解(POD)和重定向POD分析了火焰动态特性,并利用重...