T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space,parabolic flights and ground-based facilities

Dating back to the Apollo and Skylab missions, it has been reported that astronauts suffered from bacterial and viral infections during space flight or after returning to Earth. Blood analyses revealed strongly reduced capability of human lymphocytes to become active upon mitogenic stimulation. Since then, a large number of in vitro studies on human immune cells have been conducted in space, in parabolic flights, and in ground-based facilities. It became obvious that microgravity affects cell morphology and important cellular functions. Observed changes include cell proliferation, the cytoskeleton, signal transduction and gene expression. This review gives an overview of the current knowledge of T cell regulation under altered gravity conditions obtained by in vitro studies with special emphasis on the cell culture conditions used. We propose that future in vitro experiments should follow rigorous standardized cell culture conditions, which allows better comparison of the results obtained in different flight- and ground-based experiment platforms.     

河北省计算机一级考试上机操作题考点总结与分析

河北省计算机一级考试是面向省内普通高校在校学生的计算机等级考试，是用人单位进行计算机操作水平认定的重要标准，在高校中备受重视。本论文首先分析了河北省计算机一级考试的特点，然后总结分析了2006-2008年度考试操作题的考点分布及变化趋势。最后提出了正确备考的建议和策略。     

Upwards migration phenomenon on molten lunar regolith: New challenges and prospects for ISRU

As part of our research on the feasibility of producing commodities from lunar regolith by thermal-driven processes with minimal terrestrial precursors we need to characterize, reproduce, and understand thermophysical properties of the molten regolith still unforeseen under the lunar vacuum conditions at a scalable sample size. Two unanticipated phenomena, apparently caused by lunar melt’s surface tension under vacuum, have been revealed in our research work, vacuum void formation and upwards migration. In this paper we present our findings and thinkable explanation on the upwards migration phenomenon experimentally observed and consistently replicated as JSC-1A lunar regolith simulant melted at high vacuum. Upwards migration of molten lunar regolith will make future lunar ISRU’s melting processes both challenging as molten bulk material would migrate upwards along the container’s walls, and also promising on new opportunities for alternative ISRU’s sustainable processes as regolith’s upwards migration takes place in uniformed thin-film pattern. Among the potential ISRU’s processes that might use controlled thermal thin-film-based migration without the necessity of terrestrial precursors are production of feedstock for 3D printing, fractional separation of regolith’s component’s (O₂, metals, and alloys) via pyrolysis, film coating, purification of valuables solid crystals including silicon, and fabrication of key elements for microfluidic, and MEMS devices. Thermal upwards migration phenomenon on JSC-1A’s melt is formulated and explained by the authors as due to thermal Marangoni effect (also known as thermo-capillarity) in which temperature gradients within the melt’s bulk and along the crucible’s wall yield the surface tension large enough to supersede the gravitational force and yield the experimentally observed upwards thin-film migration. As far as the authors know, upwards thermal migration of molten JSC-1A (or other lunar simulant regolith) under vacuum has not been reported in the literature. A thermal mathematical model accounting for thermal Marangoni effect on molten JSC-1A agrees with what experimentally was observed, the formation of the meniscus on the melt-wall surface interface along with an incipient upwards migration in thin-film pattern along the crucible wall that, according to the model, experiences large temperature gradient, an important factor to trigger the thermal Marangoni effect along with the fact that surface tension of the molten lunar regolith material is temperature dependent.     

一种基于改进A*算法的三维航迹规划方法

采用了一种改进的网格A*算法进行了飞行器的三维航迹规划。将启发函数中的直线距离替换为折距,对其进行了改进。改进后的启发函数有效地减少了规划过程中扩展的节点数,从而减少了搜索时间,并且扩展节点时,只选择满足飞行器的飞行性能约束的邻点,减小了搜索空间。仿真结果表明,应用该规划方法,飞行器能够进行在线实时三维航迹规划。     

某类任务的无人作战飞机航路规划

讨论了对于包含了既是威胁又有价值的节点的任务模型,无人作战飞机航路规划问题解决的思路和关键环节,并构建了数学模型,然后应用A*启发算法求解各个目标点的最优航路,并依据作战指挥人员对作战方案的总体把握给出的权衡因子,计算每个目标点取得的费效比,确定满足一定条件下最先攻击目标.实例仿真表明该方法可以有效地解决这类任务的航路规划问题.     

复杂环境下的A/C模式信号处理算法及其实现

本文基于软件无线电的思想,提出一种复杂环境下的A/C模式信号处理算法,该算法从脉冲识别,A/C模式框架判决以及信息代码提取三个方面进行了研究,在识别多目标混叠、拒绝目标幻影,避免异步串扰方面,达到了较好的效果,并在FPGA上实现了该算法.     

YH-1火星探测器设计及研制进展

介绍了中国首颗YH-1火星探测器的任务功能、组成和主要技术指标。给出了探测器设计中的火星探测超低温适应、深空探测自主姿态确定与控制、超远距离通信、休眠唤醒和剩磁控制等关键技术,以及相应的解决途径。试验和验证结果表明：YH-1火星探测器的设计满足火星探测特殊环境的任务要求。其设计和试验技术可直接用于我国其他深空探测项目,为后续深空探测积累了经验。     

高速帧转移型面阵CCD器件的时序设计

介绍了512×512高速帧转移面阵CCD器件时序设计的方法。在分析器件结构和时序关系的’基础上,确定了时序设计的主要参数,并利用复杂可编程逻辑器件（CPLD）EPM7256AETC100—5实现了CCD器件工作所需的各种时序信号。通过时序仿真证明,设计方法正确可行,运行稳定。     

高校图书流通的5M1E管理法

借鉴质量管理中的"人机料法环测"(5M1E)因果分析管理方法,提出了高校图书流通管理的5M1E分析管理方法.在分析高校图书流通过程中诸要素的作用及其相互关系的基础上,阐述了"以读者为核心,以网络为平台,以图书为对象,依规程做约束.依测量做评价,依环境做创新"的高校图书流通管理指导思想及分析管理方法.     

基于DSP的片外FLASH自举引导的实现

利用多通道缓冲串口McBSPO实现了TMS320VC5509A DSP与外部串行Flash的自举引导,完成了用DSP控制Flash进行在线系统编程,重点介绍了DSP与Flash接口电路的设计,同时对Flash的烧录过程及软件编程部分进行了详细说明.通过在实际工程中的应用验证,表明了该方案切实可行.