Effects of space flight exposure on cell growth,tumorigenicity and gene expression in cancer cells

It is well recognized that harsh outer space environment, consisting of microgravity and radiation, poses significant health risks for human cells. To investigate potential effects of the space environment exposure on cancer cells we examined the biological changes in Caski cells carried by the “Shen Zhou IV” spaceship. After exposure for 7 days in spaceflight, 1440 survival subclonal cell lines were established and 4 cell lines were screened. 44F10 and 17E3 were selected because of their increased cell proliferation and tumorigenesis, while 48A9 and 31F2 had slower cytological events. Experiments with cell proliferation assay, flow cytometry, soft agar assay, tumorigenesis assay and DNA microarray analysis have shown that selected cell lines presented multiple biological changes in cell morphology, cell growth, tumorigenicity and gene expression. These results suggest that space environment exposure can make significant biological impact on cancer cells and provide an entry point to find the immunological target of tumorigenesis.     

A combination method using evolutionary algorithms in initial orbit determination for too short arc

With the combination of two evolutionary algorithms EDA and DE, a new method of initial orbit determination for satellites based on ground-based too-short-arc is established. Compared with other algorithms, the proposed method focuses on the most densely populated region in the solution space rather than the individual with best fitness value. Both the global information and local information are well fused in the search of optimum. In the method $(a,e,M)$ are treated as variables of the optimization, and the optimization procedure is carried out as a two-stage hierarchical optimization problem which has three variables for each stage. Kernel density estimation is applied to build the probability distribution model without any assumptions of the specified distribution, accompanied by handling semi-major axis and eccentricity as a pair of dependent variables in the construction of the probability for the correlation between them in the practice. Numerical experiments with real ground-based observations show that the proposed method is applicable to too-short-arc with even 3?s, and the result of bias in several kilometers can be achieved with $5^{″}$ error added to angular measurements.     

Calibration errors in determining slant Total Electron Content (TEC) from multi-GNSS data

The global navigation satellite system (GNSS) is presently a powerful tool for sensing the Earth's ionosphere. For this purpose, the ionospheric measurements (IMs), which are by definition slant total electron content biased by satellite and receiver differential code biases (DCBs), need to be first extracted from GNSS data and then used as inputs for further ionospheric representations such as tomography. By using the customary phase-to-code leveling procedure, this research comparatively evaluates the calibration errors on experimental IMs obtained from three GNSS, namely the US Global Positioning System (GPS), the Chinese BeiDou Navigation Satellite System (BDS), and the European Galileo. On the basis of ten days of dual-frequency, triple-GNSS observations collected from eight co-located ground receivers that independently form short-baselines and zero-baselines, the IMs are determined for each receiver for all tracked satellites and then for each satellite differenced for each baseline to evaluate their calibration errors. As first derived from the short-baseline analysis, the effects of calibration errors on IMs range, in total electron content units, from 1.58 to 2.16, 0.70 to 1.87, and 1.13 to 1.56 for GPS, Galileo, and BDS, respectively. Additionally, for short-baseline experiment, it is shown that the code multipath effect accounts for their main budget. Sidereal periodicity is found in single-differenced (SD) IMs for GPS and BDS geostationary satellites, and the correlation of SD IMs over two consecutive days achieves the maximum value when the time tag is around 4?min. Moreover, as byproducts of zero-baseline analysis, daily between-receiver DCBs for GPS are subject to more significant intra-day variations than those for BDS and Galileo.     

Optimal trajectory planning of free-floating space manipulator using differential evolution algorithm

The existence of the path dependent dynamic singularities limits the volume of available workspace of free-floating space robot and induces enormous joint velocities when such singularities are met. In order to overcome this demerit, this paper presents an optimal joint trajectory planning method using forward kinematics equations of free-floating space robot, while joint motion laws are delineated with application of the concept of reaction null-space. Bézier curve, in conjunction with the null-space column vectors, are applied to describe the joint trajectories. Considering the forward kinematics equations of the free-floating space robot, the trajectory planning issue is consequently transferred to an optimization issue while the control points to construct the Bézier curve are the design variables. A constrained differential evolution (DE) scheme with premature handling strategy is implemented to find the optimal solution of the design variables while specific objectives and imposed constraints are satisfied. Differ from traditional methods, we synthesize null-space and specialized curve to provide a novel viewpoint for trajectory planning of free-floating space robot. Simulation results are presented for trajectory planning of 7 degree-of-freedom (DOF) kinematically redundant manipulator mounted on a free-floating spacecraft and demonstrate the feasibility and effectiveness of the proposed method.     

用灵敏度分析同步电液伺服系统误差

采用灵敏度方法来分析电液伺服系统中各参数变化对系统动态特性的影响，通过对参变量变动所引起的微分方程解变动的研究，可以分析系统精度受各参变量影响的大小。     

物理启发的深度学习模型及其在热端部件散热中的应用

热端部件散热是众多空天设备的关键技术。表面温度分布是散热设计中用到的重要信息,常规的解析建模手段和机器学习方法均无法有效地表达此类高维信息。近年来兴起的图像深度学习算法是解决表面温度信息预测的有效手段。然而,现有的基于大数据的深度学习方法往往对于物理数据和小样本数据不适用,体现为泛化精度差、数据兼容性差、可解释性差。因此,有必要结合传热的先验知识发展物理启发的新型深度学习算法,以增强高自由度、高复杂度散热对象上的设计能力。本文基于卷积算子和有限差分求解方式的类比关系,提出了一种物理启发式的循环卷积神经网络。以横向出流的冲击冷却为例,开展了变计算域大小、变工况、变尺寸的批量数值模拟,获取了冲击冷却关键特征的小样本图像数据。进一步通过神经网络的训练,构建了多参数、大范围内有较好拟合能力的温度、传热系数、压力代理模型。研究结果表明,本文提出的物理启发神经网络模型,对于计算域大小没有限制,可以统一表达不同空间范围内获取的物理数据的共性规律。模型的各类超参设定均具有明确的物理意义,且与经典的微分方程求解理论有一定的类比关系,增强了神经网络调参的方向性。通过传热物理规律与黑箱模型的融合,本文实现了小样本多参数物理数据的共性建模。该方法可以迅速重构热端部件的高维分布信息,可服务于热端部件的快速分析设计以及优化。     

The update of BDS-2 TGD and its impact on positioning

Timing group delay (TGD) is an important parameter that affects the positioning performance of global navigation satellite systems (GNSS). The BeiDou navigation satellite system (BDS) broadcasts TGD corrections from B3I frequency to B1I and B2I frequencies, namely TGD₁ and TGD₂. On July 21, 2017, BDS updated TGD values with a maximum change of more than 4 ns. In this contribution, we explain the motivation for the BDS TGD update, which is due to the systematic bias between narrowly correlated and widely correlated pseudo-ranges in BDS monitoring receivers. To investigate the impact of the updated TGD, BDS signal-in-space range error (SISRE) and user positioning performance regarding single point positioning (SPP) and precise point positioning (PPP) are analyzed. Results show that after the update of TGD, the difference between the new TGD and multi-GNSS experiment (MGEX) differential code bias (DCB) decreases from 1.38 ns to 0.29 ns on TGD₁ and from 0.40 ns to 0.25 ns on TGD₂. With the contribution of more accurate TGD, the systematic bias of BDS radial SISRE no longer exists, and the overall BDS SISRE also reduces from 1.33 m to 0.87 m on B1I/B2I frequency, from 1.05 m to 0.89 m on B1I frequency, from 0.92 m to 0.91 m on B2I frequency, respectively, which proves the similar precision of BDS TGD and MGEX DCB. One week of statistical results from 28 globally distributed MGEX stations shows that the SPP performance improves on non-B3I frequencies after the TGD update, with a maximum improvement of more than 22% for the B1I/B2I or B1I/B3I combination. The new TGD mainly reduces SPP positioning bias in the East component. The updated TGD also slightly improves the PPP convergence performance for the B1I/B3I combination, but mostly contributes to a more accurate estimation of the receiver clock and ambiguities.     

Fuel-optimal and Energy-optimal guidance schemes for lunar soft landing at a desired location

Two guidance schemes (i) fuel-optimal (ii) energy-optimal to realize soft landing at a desired location on the moon are developed using the optimal control laws. The optimal control laws are obtained by solving a two-point boundary value problem formulated based on Pontryagin’s principle. The guidance laws, adapted from the optimal control laws, are obtained as a function of unknown co-state variables. Differential Transformation (DT) technique is employed to determine the unknown co-states at each time instant of landing trajectory using the information on the current vehicle state, target landing site (loaded on-board apriori) and the time-to-go. The numerical integration of co-state dynamics is avoided due to the DT based approach. The time-to-go, a critical parameter for any guidance scheme, is computed and updated real time using a simple strategy which uses the current and end states. The simple strategy for time-to-go works well even when the shape of the trajectory is nonlinear. Extensive analysis is carried out to evaluate and compare the proposed guidance schemes. Further, the proposed schemes are compared with other popular guidance schemes. The DT based proposed schemes help quantify the landing masses for fuel-optimal and energy-optimal objectives. Other features of the proposed schemes are that they do not assume constant gravity field and independent of reference trajectory.     

Estimation of QZSS differential code biases using QZSS/GPS combined observations from MGEX

As an important error source in Global Navigation Satellite System (GNSS) positioning and ionospheric modeling, the differential code biases (DCB) need to be estimated accurately, e.g., the regional Quasi-Zenith satellite system (QZSS). In this paper, the DCB of QZSS is estimated by adopting the global ionospheric modeling method based on QZSS/GPS combined observations from Multi-GNSS experiment (MGEX). The performance of QZSS satellite and receiver DCB is analyzed with observations from day of year (DOY) 275–364, 2018. Good agreement between our estimated QZSS satellite DCB and the products from DLR and CAS is obtained. The bias and root mean square (RMS) of DCB are mostly within ±0.3 ns. The day-to-day fluctuation of the DCB time series is less than 0.5 ns with about 96% of the cases for all satellites. However, the receiver DCB is a little less stable than satellite DCB, and their standard deviations (STDs) are within 1.9 ns. The result shows that the stability of the receiver DCBs is not significantly related to the types of receiver or antenna.     

An improved sea level retrieval method using the differential evolution of GNSS SNR data

This paper presents an improved new method with differential evolution and the cubic spline approach is proposed to retrieve sea level height based on GNSS SNR observations from a single geodetic receiver. Considering the B-spline function is unstable at the beginning or end, and the feature that B-spline functions do not pass through nodes may introduce errors. Thus, the cubic spline is applied to the retrieval process and accounts for a continuous and smooth in sea level retrieval time series. Besides, the biases caused by tropospheric delay and dynamic sea level are considered and corrected. Testing data from two stations with different tidal range and the final solution agrees well with measurements from co-located tide gauges, reaching the RMSE of 3.67 cm at Friday Harbor, Washington, and 1.36 cm at Onsala, Sweden. Comparison of the nonlinear least squares, this method leads to a clear increase in precision of the sea level retrievals within 50%. Additionally, referring to the result of Purnell et al. (2020) and the IAG inter-comparison campaign, the results of this paper show more potential.