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Marlise A. dos Santos Cynthia Bosquillon Thais Russomano Alamelu Sundaresan Felipe Falcão Christopher Marriott Ben Forbes 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2010
Although it has been suggested that microgravity might affect drug absorption in vivo, drug permeability across epithelial barriers has not yet been investigated in vitro during modelled microgravity. Therefore, a cell culture/diffusion chamber was designed specifically to accommodate epithelial cell layers in a 3D-clinostat and allow epithelial permeability to be measured under microgravity conditions in vitro with minimum alteration to established cell culture techniques. Human respiratory epithelial Calu-3 cell layers were used to model the airway epithelium. Cells grown at an air interface in the diffusion chamber from day 1 or day 5 after seeding on 24-well polyester Transwell cell culture inserts developed a similar transepithelial electrical resistance (TER) to cells cultured in conventional cell culture plates. Confluent Calu-3 layers exposed to modelled microgravity in the 3D-clinostat for up to 48 h maintained their high TER. The permeability of the paracellular marker 14C-mannitol was unaffected after a 24 h rotation of the cell layers in the 3D-clinostat, but was increased 2-fold after 48 h of modelled microgravity. It was demonstrated that the culture/diffusion chamber developed is suitable for culturing epithelial cell layers and, when subjected to rotation in the 3D-clinostat, will be a valuable in vitro system in which to study the influence of microgravity on epithelial permeability and drug transport. 相似文献
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用径向法测量了经编双轴向玻璃纤维织物的渗透率,研究了织物结构、纤维体积分数和注入压力对渗透率的影响。实验表明,经编双轴向玻璃纤维织物的渗透率呈各向异性,随着纤维体积分数增大,织物渗透率减小,各向异性的程度增加。在低的纤维体积分数下,低的注入压力影响渗透率的精确测量,注入压力增大到一定值时,纤维渗透率保持恒定。 相似文献
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研究了热处理对铸铁基多孔陶瓷复合材料组织与性能的影响。结果表明,热处理正火、淬火均可不同程度地提高该特种复合的整体强度与耐磨性,而不影响铸铁一陶瓷的界面结构及材料的透气性。 相似文献
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针对传统蜂窝吸波材料在低频段吸波效果差的特点,设计了一种蜂窝内壁加载回字形导线的复合吸波结构。这种回形线组合成的二维阵列本身是一种磁导率近零的频率选择表面。采用的蜂窝吸波结构高度为30 mm,吸波涂层厚度0.024 2 mm。仿真结果表明,加载回形线的复合吸波结构相较原蜂窝,在0.4~2 GHz内出现吸收峰,<-10 dB带宽增加10%~50%,并且在入射角0°~60°内具有良好的吸波稳定性。可通过调节回形线的几何参数与材料方阻,实现吸低频收峰位置与带宽的调控。 相似文献
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陈萍%李宏运%陈祥宝 《宇航材料工艺》2000,30(2):44-47
通过恒压注射条件下,有机硅树脂及环氧树脂在两种不同结构玻璃纤维织物中的流动实验,利用Darcy定律测定了这两种织物的渗透率,研究了树脂类型对织物表观渗透率的影响,实验及分析结果表明:树脂类型不同,树脂与织物之间的微观浸润性也不同,使得树脂在织物内产生的毛细压力不同,因此,改变树脂类型,织物的表观渗透率也发生改变。 相似文献