Evaluation of upper body muscle activity during cardiopulmonary resuscitation performance in simulated microgravity

Performance of efficient single-person cardiopulmonary resuscitation (CPR) is vital to maintain cardiac and cerebral perfusion during the 2–4 min it takes for deployment of advanced life support during a space mission. The aim of the present study was to investigate potential differences in upper body muscle activity during CPR performance at terrestrial gravity (+1Gz) and in simulated microgravity (μG). Muscle activity of the triceps brachii, erector spinae, rectus abdominis and pectoralis major was measured via superficial electromyography in 20 healthy male volunteers. Four sets of 30 external chest compressions (ECCs) were performed on a mannequin. Microgravity was simulated using a body suspension device and harness; the Evetts–Russomano (ER) method was adopted for CPR performance in simulated microgravity. Heart rate and perceived exertion via Borg scores were also measured. While a significantly lower depth of ECCs was observed in simulated microgravity, compared with +1Gz, it was still within the target range of 40–50 mm. There was a 7.7% decrease of the mean (±SEM) ECC depth from 48 ± 0.3 mm at +1Gz, to 44.3 ± 0.5 mm during microgravity simulation (p < 0.001). No significant difference in number or rate of compressions was found between the two conditions. Heart rate displayed a significantly larger increase during CPR in simulated microgravity than at +1Gz, the former presenting a mean (±SEM) of 23.6 ± 2.91 bpm and the latter, 76.6 ± 3.8 bpm (p < 0.001). Borg scores were 70% higher post-microgravity compressions (17 ± 1) than post +1Gz compressions (10 ± 1) (p < 0.001). Intermuscular comparisons showed the triceps brachii to have significantly lower muscle activity than each of the other three tested muscles, in both +1Gz and microgravity. As shown by greater Borg scores and heart rate increases, CPR performance in simulated microgravity is more fatiguing than at +1Gz. Nevertheless, no significant difference in muscle activity between conditions was found, a result that is favourable for astronauts, given the inevitable muscular and cardiovascular deconditioning that occurs during space travel.     

Comparative survival analysis of Deinococcus radiodurans and the haloarchaea Natrialba magadii and Haloferax volcanii exposed to vacuum ultraviolet irradiation

The haloarchaea Natrialba magadii and Haloferax volcanii, as well as the radiation-resistant bacterium Deinococcus radiodurans, were exposed to vacuum UV (VUV) radiation at the Brazilian Synchrotron Light Laboratory. Cell monolayers (containing 10(5) to 10(6) cells per sample) were prepared over polycarbonate filters and irradiated under high vacuum (10(-5) Pa) with polychromatic synchrotron radiation. N. magadii was remarkably resistant to high vacuum with a survival fraction of (3.77±0.76)×10(-2), which was larger than that of D. radiodurans (1.13±0.23)×10(-2). The survival fraction of the haloarchaea H. volcanii, of (3.60±1.80)×10(-4), was much smaller. Radiation resistance profiles were similar between the haloarchaea and D. radiodurans for fluences up to 150?J m(-2). For fluences larger than 150?J m(-2), there was a significant decrease in the survival of haloarchaea, and in particular H. volcanii did not survive. Survival for D. radiodurans was 1% after exposure to the higher VUV fluence (1350?J m(-2)), while N. magadii had a survival lower than 0.1%. Such survival fractions are discussed regarding the possibility of interplanetary transfer of viable microorganisms and the possible existence of microbial life in extraterrestrial salty environments such as the planet Mars and Jupiter's moon Europa. This is the first work to report survival of haloarchaea under simulated interplanetary conditions.     

Adsorption of amino acids (ALA, CYS, HIS, MET) on zeolites: fourier transform infrared and Raman spectroscopy investigations

Minerals adsorb more amino acids with charged R-groups than amino acids with uncharged R-groups. Thus, the peptides that form from the condensation of amino acids on the surface of minerals should be composed of amino acid residues that are more charged than uncharged. However, most of the amino acids (74%) in today's proteins have an uncharged R-group. One mechanism with which to solve this paradox is the use of organophilic minerals such as zeolites. Over the range of pH (pH 2.66-4.50) used in these experiments, the R-group of histidine (His) is positively charged and neutral for alanine (Ala), cysteine (Cys), and methionine (Met). In acidic hydrothermal environments, the pH could be even lower than those used in this study. For the pH range studied, the zeolites were negatively charged, and the overall charge of all amino acids was positive. The conditions used here approximate those of prebiotic Earth. The most important finding of this work is that the relative concentrations of each amino acid (X=His, Met, Cys) to alanine (X/Ala) are close to 1.00. This is an important result with regard to prebiotic chemistry because it could be a solution for the paradox stated above. Pore size did not affect the adsorption of Cys and Met on zeolites, and the Si/Al ratio did not affect the adsorption of Cys, His, and Met. ZSM-5 could be used for the purification of Cys from other amino acids (Student-Newman-Keuls test, p<0.05), and mordenite could be used for separation of amino acids from each other (Student-Newman-Keuls test, p<0.05). As shown by Fourier transform infrared (FT-IR) spectra, Ala interacts with zeolites through the [Formula: see text] group, and methionine-zeolite interactions involve the COO, [Formula: see text], and CH(3) groups. FT-IR spectra show that the interaction between the zeolites and His is weak. Cys showed higher adsorption on all zeolites; however, the hydrophobic Van der Waals interaction between zeolites and Cys is too weak to produce any structural changes in the Cys groups (amine, carboxylic, sulfhydryl, etc.); thus, the FT-IR and Raman spectra are the same as those of solid Cys.     

Estimation of moving heat sources with a three-dimensional unsteady inverse method

This study aims at estimating a moving heat source with a three dimensional inverse model and a high spatial resolution. In order to cope with the large amount of computations required in the three dimensional case, a linear unsteady inverse model based on the principle of superposition has been made. Two concepts are used to reduce the computation time: the first is linked to the diffusion time of the heat, and the second to the redundancy of information. Firstly, numerical tests are presented. Then, a laboratory experiment, consisting in the estimation of the flux of a moving laser beam, is described.     

Asymmetric precipitation in a coronal loop as explanation of a singular observed spectrum

Almost 10 years of solar submillimeter observations have shown new aspects of solar activity, such as the presence of rapid solar spikes associated with the launch of coronal mass ejections and an increasing submillimeter spectral component in flares. We analyse the singular microwave–submillimeter spectrum of an M class solar flare on 20 December, 2002. Flux density observations measured by Sun patrol telescopes and the Solar Submillimeter Telescope are used to build the radio spectrum, which is fitted using Ramaty’s code. At submillimeter frequencies the spectrum shows a component different from the microwave classical burst. The fitting is achieved proposing two homogeneous sources of emission. This theoretical fitting is in agreement with differential precipitation through a magnetically asymmetric loop or set of loops. From a coronal magnetic field model we infer an asymmetric magnetic structure at the flare location. The model proposed to quantify the differential precipitation rates due to the asymmetry results in a total precipitation ratio Q₂/Q₁≈10⁴–10⁵, where Q₁(Q₂) represents the total precipitation in the loop foot with the high (low) magnetic field intensity. This ratio agrees with the electron total number ratio of the two sources proposed to fit the radio spectrum.     

Optimization of transfers under constraints on the thrust direction: II

This paper completes the study of optimal transfers with constraints imposed on the thrust vector direction that was opened by paper [1]. The linear inhomogeneous and homogeneous constraints on the thrust direction are considered (specified either by equalities or inequalities), as well as mixed constraints. Some examples of the constraints are presented. A modified method of the transporting trajectory is applied in order to find the optimal transfer under the linear constraints on the thrust direction. This method also gives the necessary condition for a transfer possibility at a given constraint on the thrust direction. A numerical example is considered, in which the propellant consumption is analyzed for the cases of transfers with and without constraints.     

翼型风洞侧壁干扰的数值模拟研究

运用Navier-Stokes数值模拟对翼型模拟试验对风洞侧壁干扰进行模拟，将简单代数湍流模型扩展用于机翼／风洞侧壁结合区流动，分析了风洞实验侧壁干扰问题的形成机理和影响翼型实验侧壁干扰的各种因素，如翼型展长、风洞侧壁边界层厚度及侧壁边界层抽吸等，对实验结果的影响，得出了一些有用的结论。计算格式空间采用中心有限体积离散，时间采用多步Runge-Kutta时间步长格式进行积分。计算结果证明了该方法的可行性和优越性。     

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm. It will use a mechanical mole and grinder to obtain samples from below the surface, under rocks, and inside rocks. Sample analysis by a mass spectrometer will include isotopic analysis. An optical microscope, an X-ray spectrometer and a Mossbauer spectrometer will conduct in-situ rock studies.     

WSO-UV project

During last three decades, astronomers have enjoyed continuous access to the 100–300 nm ultraviolet (UV) spectral range where the resonance transitions of the most abundant atoms and ions (at temperatures between 3000 and 300 000 K) reside. This UV range is not accessible from ground-based facilities. The successful International Ultraviolet Explorer (IUE) observatory, the Russian ASTRON mission and successor instruments such as the Galaxy Evolution Explorer (GALEX) mission or the COS and STIS spectrographs on-board the Hubble Space Telescope (HST) prove the major impact of observations in the UV wavelength range in modern astronomy. Future access to space-based observatories is expected to be very limited. For the next decade, the post-HST era, the World Space Observatory – Ultraviolet (WSO–UV) will be the only 2-m class UV telescope with capabilities similar to the HST. WSO–UV will be equipped with instruments for imaging and spectroscopy and it will be a facility dedicated, full-time, to UV astronomy. In this article, we briefly outline the current status of the WSO–UV mission and the science management plan.