Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition

Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.     

Quaternion regularization and trajectory motion control in celestial mechanics and astrodynamics: II

Problems of regularization in celestial mechanics and astrodynamics are considered, and basic regular quaternion models for celestial mechanics and astrodynamics are presented. It is shown that the effectiveness of analytical studies and numerical solutions to boundary value problems of controlling the trajectory motion of spacecraft can be improved by using quaternion models of astrodynamics. In this second part of the paper, specific singularity-type features (division by zero) are considered. They result from using classical equations in angular variables (particularly in Euler variables) in celestial mechanics and astrodynamics and can be eliminated by using Euler (Rodrigues-Hamilton) parameters and Hamilton quaternions. Basic regular (in the above sense) quaternion models of celestial mechanics and astrodynamics are considered; these include equations of trajectory motion written in nonholonomic, orbital, and ideal moving trihedrals whose rotational motions are described by Euler parameters and quaternions of turn; and quaternion equations of instantaneous orbit orientation of a celestial body (spacecraft). New quaternion regular equations are derived for the perturbed three-dimensional two-body problem (spacecraft trajectory motion). These equations are constructed using ideal rectangular Hansen coordinates and quaternion variables, and they have additional advantages over those known for regular Kustaanheimo-Stiefel equations.     

在制品管理中条码技术的应用

针对面向订单的单件、小批量生产制造企业,设计了一套条码数据采集系统,分析了主要运作流程和功能模块.在在制品的管理中提出了基于不同级别的工件生产状态定义,并给出了相应的加工、检验判定准则.经实际使用证明条码技术运用于工业现场是可行的.     

Amplitude modulation of VLF emission and absorption of cosmic noise by <Emphasis Type="Italic">Pc</Emphasis>5 geomagnetic pulsations in the period of geomagnetic storms on October 30–31, 2003

Modulation of the VLF emission and riometric absorption by Pc5 geomagnetic pulsations is studied in the period of strong geomagnetic disturbances on October 30–31, 2003. Some conclusions about the regime of pitch-angular diffusion into the loss cone are made. The better coincidence of VLF emission modulation with geomagnetic pulsations in other longitude sectors is explained by the global character of excitation of the pulsations and by damping of their amplitudes at the meridian of observation of the VLF emission, which is associated with intensification of auroral electrojets.Translated from Kosmicheskie Issledovaniya, Vol. 42, No. 6, 2004, pp. 632–639.Original Russian Text Copyright © 2004 by Solovyev, Mullayarov, Baishev, Barkova, Samsonov.     

On the problem of lunar radiation environment

In connection with projects of manned bases on the Moon it becomes topical to estimate radiation danger for their inhabitants. In this paper we describe a method of evaluation of the radiation environment on the lunar surface produced by galactic and solar cosmic rays. The roles of both primary and secondary radiations generated in the depth of the lunar soil under the action of high-energy protons and nuclei are taken into account. Calculated fluxes of particles are used in order to estimate annual averaged absorbed and equivalent local dose rates in tissues. It is established that in the lunar rock the contribution of secondary neutrons to the dose rate exceeds that of protons. The contribution of the secondary particles generated by nuclei of galactic cosmic rays to the dose rate is estimated.     

Theoretical determination of shot peening process parameters

In this paper, a proper choice of technological parameters for a shot peening process is considered, namely, the shot diameter, shot blast velocity, density of shot material, and depth of a plastically deformed layer-depending on the material being processed. The data presented can be used in calculations of technological parameters of FV monolithic panel shaping.     

Antideuteron based dark matter search with GAPS: Current progress and future prospects

The General Antiparticle Spectrometer (GAPS) is a new approach to the indirect detection of dark matter. It relies on searching for primary antideuterons produced in the annihilation of dark matter in the galactic halo. Low energy antideuterons produced through Standard Model processes, such as collisions of cosmic-rays with interstellar baryons, are greatly suppressed compared to primary antideuterons. Thus a low energy antideuteron search provides a clean signature of dark matter. In GAPS antiparticles are slowed down and captured in target atoms. The resultant exotic atom deexcites with the emission of X-rays and annihilation pions, protons and other particles. A tracking geometry allows for the detection of the X-rays and particles, providing a unique signature to identify the mass of the antiparticle. A prototype detector was successfully tested at the KEK accelerator in 2005, and a prototype GAPS balloon flight is scheduled for 2011. This will be followed by a full scale experiment on a long duration balloon from Antarctica in 2014. We discuss the status and future plans for GAPS.     

A Parallel Adaptive 3D MHD Scheme for Modeling Coronal and Solar Wind Plasma Flows

A parallel adaptive mesh refinement (AMR) scheme is described for solving the governing equations of ideal magnetohydrodynamics (MHD) in three space dimensions. This solution algorithm makes use of modern finite-volume numerical methodology to provide a combination of high solution accuracy and computational robustness. Efficient and scalable implementations of the method have been developed for massively parallel computer architectures and high performance achieved. Numerical results are discussed for a simplified model of the initiation and evolution of coronal mass ejections (CMEs) in the inner heliosphere. The results demonstrate the potential of this numerical tool for enhancing our understanding of coronal and solar wind plasma processes. This revised version was published online in June 2006 with corrections to the Cover Date.     

Putative graviperception mechanisms of protists.

Many (if not all) free-living cells use the gravity vector for their spatial orientation (gravitaxis). Additional responses may include gravikinesis as well as changes in morphological and physiological parameters. Though using essentially different modes of locomotion, ameboid and ciliated cells seem to rely on common fundamental graviperception mechanisms. Uniquely in the ciliate family Loxodidae a specialized intracellular gravireceptor organelle has been developed, whereas in all other cells common cell structures seem to be responsible for gravisensing. Changes in direction or magnitude of acceleration (from 0 to 5 g) as well as experiments in density-adjusted media strongly indicate that either the whole cytoplasm or dense organelles like nuclei act as statoliths and open directly or via cytoskeletal elements mechano-sensitive ion channels in the cell membrane. A recent spaceflight experiment (S/MM-06) demonstrated that prolonged (9 d) actual weightlessness did not affect the ability of Loxodes to respond to acceleration stimuli. However, prolonged cooling (> or = l4 d, 4-10 degrees C) destroyed the ability for gravitactic orientation of Paramecium. This may reflect a profound effect either on the gravireceptor itself or on the gravity-signal processing. In gravity signalling the ubiquitous second messenger cAMP may be involved in acceleration-stimulus transduction.