Effect of potassium and calcium loading on healthy subjects under hypokinesia and physical exercise with fluid and salt supplements

The objective of this investigation was to determine the acute responses to the electrolyte challenges under hypokinesia and physical exercise (PE) of different intensities with fluid and salt supplementation (FSS). The studies were performed on 12 physically healthy male volunteers aged 19-24 years under 364 days of hypokinesia (decreased number of steps per day) with a set of PE with FSS. The volunteers were divided into two equal groups. The first group was subjected to a set of intensive PE and the second group was submitted to a set of moderate PE. Both groups of subjects consumed daily water and salt supplements that aimed to increase the body hydration level. For simulation of the hypokinetic effect all subjects were kept under an average of 3000 steps per day. Functional tests with a potassium chloride (KCl) and calcium lactate (Cal) load were performed during the hypokinetic period of 364 days and the 60-day, prehypokinetic period that served as control, while both groups of subjects consumed daily calcium and potassium supplements. The concentration of electrolyte and hormone levels in the blood and their excretion rate in urine were determined. Renal excretion of calcium and potassium and the blood concentration thereof increased markedly in both groups of subjects. With the potassium chloride load tests the increased potassium excretion was accompanied by higher aldosterone and insulin blood levels, and with the calcium lactate load tests the increased calcium excretion was accompanied by a decreased parathyroid content in the blood. FSS and PE, regardless of intensity, failed to attenuate calcium and potassium losses. Additional intake of KCl and Cal also failed to normalize potassium and calcium abnormalities. It was concluded that during the KCl and Cal loading tests, the increased losses of potassium and calcium in the hypokinetic subjects were due to the inability of their bodies to retain these electrolytes, and that electrolyte abnormalities could not be reversed by PE or rehydration in individuals subjected to prolonged restriction of motor activity.     

基于CFD技术的鼻腔输药的流动特性研究

鼻腔输药作为一种新颖的输药方式,具有方便可靠的特点,不仅可以适用于局部而且适用于全身用药,已经受到广泛的重视。但由于人类的呼吸道复杂的立体结构使得鼻腔输药成为生物医药研究的一个长期的挑战。利用CFD(计算流体动力学,Computational Fluid Dynamics)技术对鼻腔输药的流动特性进行研究,对一个基于真实的人类鼻腔解剖的3D模型的输药的流动过程进行了分析,着重研究了不同的药物颗粒的流动和沉淀特性。利用CFD的商用软件FLUENT在层流情况下对不同的密度、直径和流动速率的药物颗粒在鼻腔中流动进行了数值模拟,并对计算结果进行了比较分析。CFD研究的结果为鼻腔输药这种新颖的药物输送方式的优化设计提供了依据。     

Phase Space Density Analysis of Energy Transport in the Earth’s Magnetotail

Two energetic events in the Earth’s magnetotail detected by Geotail are examined with detailed analysis of three-dimensional velocity phase space density. It is found that the occurrence of multiple ion components is high during these dynamic episodes. Different populations evolve independently of each other, suggesting particles from multiple activity sites contributing to the observed phase space density. The transport properties with consideration of multiple components are evaluated, with the result showing significant differences from those based on a single fluid approach. This comparison indicates that precise evaluation of the energy and magnetic flux transport of energetic events in the magnetotail requires resolving individual populations in the phase space density.     

Differential-game-based guidance law using target orientation observations

Modern 4th generation air-to-air missiles are quite capable of dealing with today's battlefield needs. Advanced aerodynamics, highly efficient warheads and smart target acquisition systems combine to yield higher missile lethality than ever. However, in order to intercept highly maneuverable targets, such as future unmanned combat air vehicles (UCAV), or to achieve higher tracking precision for missiles equipped with smaller warheads, further improvement in the missile guidance system is still needed. A new concept is presented here for deriving improved differential-game-based guidance laws that make use of information about the target orientation, which is acquired via an imaging seeker. The underlying idea is that of using measurements of the target attitude as a leading indicator of target acceleration. Knowledge of target attitude reduces the reachable set of target acceleration, facilitating the computation of an improved estimate of the zero-effort miss (ZEM) distance. In consequence, missile guidance accuracy is significantly improved. The new concept is applied in a horizontal interception scenario, where it is assumed that the target maneuver direction, constituting a partial attitude information, can be extracted via processing target images, acquired by an imaging sensor. The derivation results in a new guidance law that explicitly exploits the direction of the target acceleration. The performance of the new guidance law is studied via a computer simulation, which demonstrates its superiority over existing state-of-the-art differential-game-based guidance laws. It is demonstrated that a significant decrease in the miss distance can be expected via the use of partial target orientation information.     

The Genesis Solar-Wind Collector Materials

Genesis (NASA Discovery Mission #5) is a sample return mission. Collectors comprised of ultra-high purity materials will be exposed to the solar wind and then returned to Earth for laboratory analysis. There is a suite of fifteen types of ultra-pure materials distributed among several locations. Most of the materials are mounted on deployable panels (‘collector arrays’), with some as targets in the focal spot of an electrostatic mirror (the ‘concentrator’). Other materials are strategically placed on the spacecraft as additional targets of opportunity to maximize the area for solar-wind collection. Most of the collection area consists of hexagonal collectors in the arrays; approximately half are silicon, the rest are for solar-wind components not retained and/or not easily measured in silicon. There are a variety of materials both in collector arrays and elsewhere targeted for the analyses of specific solar-wind components. Engineering and science factors drove the selection process. Engineering required testing of physical properties such as the ability to withstand shaking on launch and thermal cycling during deployment. Science constraints included bulk purity, surface and interface cleanliness, retentiveness with respect to individual solar-wind components, and availability. A detailed report of material parameters planned as a resource for choosing materials for study will be published on a Genesis website, and will be updated as additional information is obtained. Some material is already linked to the Genesis plasma data website (genesis.lanl.gov). Genesis should provide a reservoir of materials for allocation to the scientific community throughout the 21st Century. This revised version was published online in August 2006 with corrections to the Cover Date.     

Interacting multiple model tracking with target amplitude feature

A recursive tracking algorithm is presented which uses the strength of target returns to improve track formation performance and track maintenance through target maneuvers in a cluttered environment. This technique combines the interacting multiple model (IMM) approach with a generalized probabilistic data association (PDA), which uses the measured return amplitude in conjunction with probabilistic models for the target and clutter returns. Key tracking decisions can be made automatically by assessing the probabilities of target models to provide rapid and accurate decisions for both true track acceptance and false track dismissal in track formation. It also provides the ability to accurately continue tracking through coordinated turn target maneuvers     

Parallel resonant converter with LLC-type commutation

It is shown that by using a proper transformation of state variables, the third-order system of the parallel resonant converter (PRC) with LLC-type commutation can be analyzed by means of a two-dimensional state-plane diagram. A set of characteristic curves which can be used for the converter design is derived from the analysis. It is shown from these curves that the converter possesses more desirable features than the conventional PRC     

Review of flow control mechanisms of leading-edge vortices

Vortex control concepts employed for slender and nonslender delta wings were reviewed. Important aspects of flow control include flow separation, vortex formation, flow reattachment, vortex breakdown, and vortex instabilities. The occurrence and relative importance of these phenomena strongly depend on the wing sweep angle. Various flow control methods were discussed: multiple vortices, control surfaces, blowing and suction, low-frequency and high-frequency excitation, feedback control, passive control with wing flexibility, and plasma actuators. For slender delta wings, control of vortex breakdown is achieved by modifications to swirl level and external pressure gradient acting on the vortex core. Effects of flow control methods on these two parameters were discussed, and their effectiveness was compared whenever possible. With the high-frequency excitation of the separated shear layer, reattachment and lift enhancement in the post-stall region is observed, which is orders of magnitude more effective than steady blowing. This effect is more pronounced for nonslender wings. Re-formation of vortices is possible with sufficient amplitude of forcing at the optimum frequency. Passive lift enhancement on flexible wings is due to the self-excited wing vibrations, which occur when the frequency of wing vibrations is close to the frequency of the shear layer instabilities, and promote flow reattachment.     

An interacting multiple model approach for target tracking withglint noise

The application of the interacting multiple model (IMM) estimation approach to the problem of target tracking when the measurements are perturbed by glint noise is considered. The IMM is a very effective approach when the system has discrete uncertainties in the dynamic or measurement model as well as continuous uncertainties. It is shown that this method performs better than the “score function” method. It is also shown that the IMM method performs robustly when the exact prior information of the glint noise is not available