Studies of Logarithmic Radar Receiver Using Pulse-Length Discrimination

Using a logarithmic amplifier giving a detected output followed by a high-pass filter is a technique for reducing adverse effects of distributed clutter in radar receivers. A pulse-length discriminator (PLD) used as the high-pass filter is treated here. Theoretical and experimental results for the loss in detectability introduced by this receiver, as compared with a matched filter or a good approximation thereto, have been obtained. For the case of single-hit detection, losses of 4 to 8 dB are introduced by the logarithmic amplifier/pulse-length discriminator (LOG AMP/PLD) combination; for post-detection integration, the losses are reduced to 2 to 4 dB. The latter values would apply where the LOG AMP/PLD output is presented on a PPI (plan position indicator). Some experimental results of the ability of the LOG AMP/PLD receiver to reject signals of incorrect pulse length show that signals exceeding the design pulse length by more than 25 to 50 percent are effectively suppressed. No significant short-pulse discrimination is obtained from the receiver.     

Frequency-Dependent Ionospheric Refraction Effects on the Doppler Shift of Satellite Signals

Analysis of four-frequency satellite Doppler data has allowed the separation and measurement of frequency-dependent ionospheric contributions to the Doppler shift, providing information useful in the study of errors incurred when tracking radio signals through the ionosphere. These refraction errors affect the accuracy of navigational position fixes obtained by Doppler satellite tracking systems. Some measured ionospheric refraction errors reported here are of interest because their magnitudes are significantly greater than those heretofore predicted from theoretical considerations.     

Modified Generalized Sign Test Processor for 2-D Radar

The modified generalized sign test processor is a nonparametric, adaptive detector for 2-D search radars. The detector ranks a sample under test with its neighboring samples and integrates (on a pulse-to-pulse basis) the ranks with a two-pole filter. A target is declared when the integrated output exceeds two thresholds. The first threshold is fixed and yields a 10-6 probability of false alarm when the neighboring samples are independent and identically distributed. The second threshold is adaptive and maintains a low false-alarm rate when the integrated neighboring samples are correlated and when there are nonhomogeneities, such as extraneous targets, in the neighboring cells. Using Monte Carlo techniques, probability of false-alarm results, probability of detection curves, and angular accuracy curves have been generated for this detector. The detector was built and PPI photographs are used to indicate the detector's performance when the radar is operated over land clutter.     

Parathyroid hormone-related protein is a gravisensor in lung and bone cell biology.

Parathyroid Hormone-related Protein (PTHrP) has been shown to be essential for the development and homeostatic regulation of lung and bone. Since both lung and bone structure and function are affected by microgravity, we hypothesized that 0 x g down-regulates PTHrP signaling. To test this hypothesis, we suspended lung and bone cells in the simulated microgravity environment of a Rotating Wall Vessel Bioreactor, which simulates microgravity, for up to 72 hours. During the first 8 hours of exposure to simulated 0 x g, PTHrP expression fell precipitously, decreasing by 80-90%; during the subsequent 64 hours, PTHrP expression remained at this newly established level of expression. PTHrP production decreased from 12 pg/ml/hour to 1 pg/ml/hour in culture medium from microgravity-exposed cells. The cells were then recultured at unit gravity for 24 hours, and PTHrP expression and production returned to normal levels. Based on these findings, we have obtained bones from rats flown in space for 2 weeks (Mission STS-58, SL-2). Analysis of PTHrP expression by femurs and tibias from these animals (n=5) revealed that PTHrP expression was 60% lower than in bones from control ground-based rats. Interestingly, there were no differences in PTHrP expression by parietal bone from space-exposed versus ground-based animals, indicating that the effect of weightlessness on PTHrP expression is due to the unweighting of weight-bearing bones. This finding is consistent with other studies of microgravity-induced osteoporosis. The loss of the PTHrP signaling mechanism may be corrected using chemical agents that up-regulate this pathway. In conclusion, PTHrP represents a stretch-sensitive paracrine signaling mechanism that may sense gravity.     

Effects of the diet on brain function.

The rates of synthesis by brain neurons of the neurotransmitters serotonin, acetylcholine, and the catecholamines depend on the brain levels of the respective precursor molecules. Brain levels of each precursor are influenced by their blood concentration, and for the amino acid precursors, by the blood levels of other amino acids as well. Since diet readily alters blood concentrations of each of these precursors, it thereby also influences the brain formation of their neurotransmitter products.     

Anesthesia, surgical aid and resuscitation in manned space missions.

When discussing problems related to medical service in space flight, particular attention should be given to the specific living conditions and changes associated with space flight. In disease and injury, surgery can be provided only after conservative therapy has failed. In this context gnotobiological chambers allowing surgery in aseptic conditions seem promising. A portable set of interchangeable surgical tools should be made of light-weight alloys that can be readily sterilized. Electroanalgesia in combination with auriculoacupuncture as well as peridureal anesthesia may be used as they allow normal operations in autonomous space flight conditions. Changes in the sympatho-adrenal and kallikrein-kinin systems, as well as water-electrolyte balance, should be taken into account in developing methods and means of medical service in critical situations. Special attention should be given to the prevention and treatment of brain edema in view of weightlessness-induced cephalad fluid shifts.