Parathyroid hormone-related protein is a gravisensor in lung and bone cell biology.

Parathyroid Hormone-related Protein (PTHrP) has been shown to be essential for the development and homeostatic regulation of lung and bone. Since both lung and bone structure and function are affected by microgravity, we hypothesized that 0 x g down-regulates PTHrP signaling. To test this hypothesis, we suspended lung and bone cells in the simulated microgravity environment of a Rotating Wall Vessel Bioreactor, which simulates microgravity, for up to 72 hours. During the first 8 hours of exposure to simulated 0 x g, PTHrP expression fell precipitously, decreasing by 80-90%; during the subsequent 64 hours, PTHrP expression remained at this newly established level of expression. PTHrP production decreased from 12 pg/ml/hour to 1 pg/ml/hour in culture medium from microgravity-exposed cells. The cells were then recultured at unit gravity for 24 hours, and PTHrP expression and production returned to normal levels. Based on these findings, we have obtained bones from rats flown in space for 2 weeks (Mission STS-58, SL-2). Analysis of PTHrP expression by femurs and tibias from these animals (n=5) revealed that PTHrP expression was 60% lower than in bones from control ground-based rats. Interestingly, there were no differences in PTHrP expression by parietal bone from space-exposed versus ground-based animals, indicating that the effect of weightlessness on PTHrP expression is due to the unweighting of weight-bearing bones. This finding is consistent with other studies of microgravity-induced osteoporosis. The loss of the PTHrP signaling mechanism may be corrected using chemical agents that up-regulate this pathway. In conclusion, PTHrP represents a stretch-sensitive paracrine signaling mechanism that may sense gravity.     

Transient Performance of Gyro in Spinning Spacecraft

Transient performance of a single-axis rate gyroscope mounted in a spacecraft which is spinning about the spin axis of the gyro is presented. Analytical expressions for various time-domain and frequency-domain specifications as functions of the spin rate of the vehicle are obtained. Numerical results are presented which are useful in selecting the gyro parameters if it is to be used for the measurements of the angular velocity in spinning space vehicles.     

Optimum Steady State Position, Velocity, and Acceleration Estimation Using Noisy Sampled Position Data

A one-dimensional tracking filter based on the Kalman filtering techniques for tracking of a dynamic target such as an aircraft is discussed. The target is assumed to be moving with constant acceleration and is acted upon by a plant noise which perturbs its constant acceleration motion. The plant noise accounts for maneuvers and/or other random factors. Analytical results for estimating optimum steady state position, velocity, and acceleration of the target are obtained.     

Evolution of binaries with chemically peculiar primaries

The chemically peculiar (CP) stars are classified into subgroups based on the type of peculiarities. A significant fraction of these are known to be binaries. The faster evolution of the massive component leads to a white dwarf or a neutron star. Further evolution of the binary is analysed taking into consideration, the orbital parameters, effect of magnetic field, spectroscopic peculiarities and finally the statistics of CP binaries and Low Mass X-ray Binaries (LMXB).

The possible consequences of the evolution to lead to the formation of Magnetic Cataclysmic Variables (MCV) and LMXB are discussed.     

The Soviet Union's GLONASS Navigation Satellites

GLONASS (Global Orbiting Navigation Satellite System) is the most recent satellite navigation system developed by the Soviet Union and currently in the pre-operational stage. Obvious parallels exist between GLONASS and the NAVSTAR Global Positioning System (GPS) developed in the United States and also, at present, in a pre-operational phase. In the progress towards operational status, the launch capability for NAVSTAR satellites has been seriously affected by the recent failure of the Space Shuttle Challenger, clearly increasing the prospects of GLONASS reaching operational status first. It is therefore the main purpose of this paper to discuss certain aspects of the GLONASS satellite navigation system, in particular its orbital features and radio-frequency signal characteristics. Comparisons with NAVSTAR are inevitable and for this reason, the paper begins with a brief resume of relevant features of the NAVSTAR GPS system for later reference. The main section of the paper then deals with orbital behaviour, radio frequency signal structure and channelisation using NAVSTAR as a reference point for discussion.     

Adaptive pulse compression via MMSE estimation

Radar pulse compression involves the extraction of an estimate of the range profile illuminated by a radar in the presence of noise. A problem inherent to pulse compression is the masking of small targets by large nearby targets due to the range sidelobes that result from standard matched filtering. This paper presents a new approach based upon a minimum mean-square error (MMSE) formulation in which the pulse compression filter for each individual range cell is adaptively estimated from the received signal in order to mitigate the masking interference resulting from matched filtering in the vicinity of large targets. The proposed method is compared with the standard matched filter and least-squares (LS) estimation and is shown to be superior over a variety of stressing scenarios.     

Near infrared studies of the massive X-ray binary 2S 0114+65

We present near-infrared spectroscopy of the massive X-ray binary 2S 0114+650. These observations covering the spectral range 1.08–2.35 μm span the region where Paschen and Brackett series recombination lines of hydrogen are expected to be seen, namely, Paβ , Brγ and Br 10–17 lines. The absence of any of these lines in emission supports earlier inferences that the optical component in 2S 0114+650 is unlikely to be a Be star but rather a B type supergiant. Near-IR photometry gives J = 8.78, H = 8.53 and K = 7.96; these values show marginal variations from earlier reported measurements.     

Multiband echo tomography of Sco X-1

We present preliminary results of a simultaneous X-ray/optical campaign of the prototypical LMXB Sco X-1 at 1–10 Hz time resolution. Lightcurves of the high excitation Bowen/HeII emission lines and a red continuum at λ_c  6000 Å were obtained through narrow interference filters with ULTRACAM, and these were cross-correlated with simultaneous RXTE X-ray lightcurves. We find evidence for correlated variability, in particular when Sco X-1 enters the Flaring branch. The Bowen/HeII lightcurves lag the X-ray lightcurves with a light travel time which is consistent with reprocessing in the companion star while the continuum lightcurves have shorter delays consistent with reprocessing in the accretion disc.     

A technique for estimating the probability of radiation-stimulated failures of integrated microcircuits in low-intensity radiation fields: Application to the Spektr-R spacecraft

In developing radio-electronic devices (RED) of spacecraft operating in the fields of ionizing radiation in space, one of the most important problems is the correct estimation of their radiation tolerance. The “weakest link” in the element base of onboard microelectronic devices under radiation effect is the integrated microcircuits (IMC), especially of large scale (LSI) and very large scale (VLSI) degree of integration. The main characteristic of IMC, which is taken into account when making decisions on using some particular type of IMC in the onboard RED, is the probability of non-failure operation (NFO) at the end of the spacecraft’s lifetime. It should be noted that, until now, the NFO has been calculated only from the reliability characteristics, disregarding the radiation effect. This paper presents the so-called “reliability” approach to determination of radiation tolerance of IMC, which allows one to estimate the probability of non-failure operation of various types of IMC with due account of radiation-stimulated dose failures. The described technique is applied to RED onboard the Spektr-R spacecraft to be launched in 2007.