Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy ⁵⁶Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy ⁵⁶Fe is estimated to be 143 keV/μm with the exposure conditions used in this study. For ⁵⁶Fe ions, the maximum relative biological effectiveness (RBE_max) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/μm ⁴He nuclei, high-energy ⁵⁶Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E₁ analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy ⁵⁶Fe. Exposure of cells to misoprostol did not alter ⁵⁶Fe cytotoxicity or the rate of ⁵⁶Fe-induced oncogenic transformation.     

New evidence for strong non-thermal effects in Tycho’s supernova remnant

For the case of Tycho’s supernova remnant (SNR), we present the relation between the blast wave and contact discontinuity radii calculated within the nonlinear kinetic theory of cosmic ray (CR) acceleration in SNRs. It is demonstrated that these radii are confirmed by recently published Chandra measurements which show that the observed contact discontinuity radius is very close to the shock radius. Therefore a consistent explanation of these observations can be given in terms of efficient CR acceleration which makes the medium more compressible.     

Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

A Simple Real-Time Incoherent Optical Correlator

The Theory and experimental results of a simple optical correlator are given. The optical components consist only of an incoherent source, condensing, collimating, and transforming lenses, and a photodetector. For real-time operation, a reference signal on a photographic transparency is correlated with an unknown signal on an ultrasonic light modulator. The output is a function of time proportional to the correlation function's amplitude rather than the squared amplitude generated by other optical correlators. When used for correlation in radar signal processing, the optical processor may be used for both pulse coding and decoding (pulse expansion and compression) and the decoded signal is shown to be described by Woodward's ambiguity function. The experimental results demonstrated the validity of the theory in both real and scaled time. However, developmental work is still required to improve the operation.     

Postdetection Integration Loss for Logarithmic Detectors

The effect of a logarithmic receiver on the detection performance of a radar has been determined by Green by numerical computations for up to 100 pulses integrated. It was further suggested that the loss in decibels as compared to a square-law detector would appear to be proportional to the logarithm of the number of pulses integrated. In this correspondence we show that this ?conjecture? is false, and that the additional loss when N becomes very large approaches a constant value of 2.2 dB.     

Features of rotational motion of a spacecraft descending in the Martian atmosphere

Angular motion at atmospheric entry is studied in the paper for a spacecraft with a bi-harmonic moment characteristic. Special attention is given to the case when the spacecraft possesses two stable balanced positions, and, hence, it can oscillate in dense atmospheric layers in the ranges of small or large angles of attack. The averaged equations of spacecraft motion are derived, which allow one to increase the speed of calculations by several orders of magnitude. A real example is presented, which concerns a spacecraft specially designed for descending in the Martian atmosphere.     

Coronal radio-sounding detection of a CME during the 1997 Galileo solar conjunction

Frequency fluctuations of the Galileo S-band radio signal were recorded nearly continuously during the spacecraft’s solar conjunction from December 1996 to February 1997. A strong propagating disturbance, most probably associated with a coronal mass ejection (CME), was detected on 7 February when the radio ray path proximate point was on the west solar limb at about 54 solar radii from the Sun. The CME passage through the line of sight is characterized by a significant increase in the fluctuation intensity of the recorded frequency and by an increase in the plasma speed from about 234 km s⁻¹ up to about 755 km s⁻¹. These velocity estimates are obtained from a correlation analysis of frequency fluctuations recorded simultaneously at two widely-separated ground stations. The density turbulence power spectrum is found to steepen behind the CME front. The Galileo radio-sounding data are compared with SOHO/LASCO observations of the CME in the corona and with WIND spacecraft data near the Earth’s orbit.     

Instrumentation for investigation of the depth-dose distribution by the Liulin-5 instrument of a human phantom on the Russian segment of ISS for estimation of the radiation risk during long term space flights.

Described is the Liulin-5 experiment and instrumentation, developed for investigation of the space radiation doses depth distribution in a human phantom on the Russian Segment of the International Space Station (ISS). Liulin-5 experiment is a part of the international project MATROSHKA-R on ISS. The experiment MATROSHKA-R is aimed to study the depth dose distribution at the sites of critical organs of the human body, using models of human body-anthropomorphic and spherical tissue-equivalent phantoms. The aim of Liulin-5 experiment is long term (4-5 years) investigation of the radiation environment dynamics inside the spherical tissue-equivalent phantom, mounted in different places of the Russian Segment of ISS. Energy deposition spectra, linear energy transfer spectra, flux and dose rates for protons and the biologically-relevant heavy ion components of the galactic cosmic radiation will be measured simultaneously with near real time resolution at different depths of the phantom by a telescope of silicon detectors. Data obtained together with data from other active and passive dosimeters will be used to estimate the radiation risk to the crewmembers, verify the models of radiation environment in low Earth orbit, validate body transport model and correlate organ level dose to skin dose. Presented are the test results of the prototype unit. The spherical phantom will be flown on the ISS in 2004 year and Liulin-5 experiment is planned for 2005 year.     

Performance limits of sensor-scheduling strategies in electronic support

The case is considered in which a frequency-agile receiver (FAR) for electronic support (ES) attempts to intercept radar emissions over a wide search bandwidth. It was recently shown [1,2] that a random strategy exists in which the expected intercept time can be made arbitrarily close to linear as a function of the scan period of the radar. Can a deterministic strategy be devised in which a similar linear relationship exists for the maximum intercept time? By applying the celebrated arithmetic results of van der Waerden [3] and Szemeredi [4], we show that no such strategy is possible.     

Parametric Methods for Strip-Map SAR Doppler Ambiguity Resolution

Physical modeling of the Doppler centroid (DC) can be used to predict synthetic aperture radar (SAR) Doppler ambiguity when antenna attitude is controlled or measured precisely enough. It is shown that the same model proves useful even in the cases of higher attitude uncertainty, if it is combined with suitable adaptive techniques. In this paper, Doppler ambiguity resolution is formulated as a hypothesis testing problem over a domain of integer values that are directly related to the attitude uncertainty. A test statistic is derived from the entire SAR scene using data adaptive processing. A broad class of such adaptive algorithms is analyzed in a unified way, starting from the range-azimuth coupling in the frequency domain and multilook techniques. The analysis includes two well-known and two new multilook methods for Doppler ambiguity resolution. A suitable test statistic is proposed for each of these methods and its dependency on the scene spatial correlation is discussed. Experimental results confirm the robustness of the combined scheme.