Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

On the contribution of space medicine in the public health care

With the beginning of space era, a new branch of medicine has arisen and has been developing along with human exploration of outer space. And even though space medicine mainly faces the same problems as traditional medicine--cosmonauts health care and their high efficiency--this branch, has its own features, associated with the unusual factors of space flight, of which weightlessness is the major one. During the development of manned cosmonautics (duration of a human stay in space has reached already 438 days), methods of cosmonauts medical support and monitoring of their condition have been developed, knowledge of human possibilities and methods of process of organism adaptation to various and frequently severe conditions of external environment have increased. All this led to the fact that nowadays space medicine can become useful for improvement of human health care not only in space but also on the Earth. Moreover, the problem of implementation of cosmonautics achievements, and in particular of space medicine, in practice of public health care presents one of the most important issues concerning human health care. It is also connected with public opinion which is more and more concerned about the efficiency of significant expenses on space activities, especially lately. People often are set by the questions: what has space given, what fruits has space research provided to mankind, which results of this research can be used on the Earth already today for improvement of their life, for discussion of many difficult earthly problems? In terms of using cosmonautics possibilities, its achievements for health care and treatment, it is possible to define a few branches, in which purposeful studies are carried out.     

Leg venous hemodynamics and leg volumes during a 42 day -6 degrees head-down bedrest

Seven healthy subjects were submitted to a 42-day head down bedrest, where leg venous compliance (venous distensibity index VDI) and leg volumes were assessed by mercury strain gauge plethysmography with venous occlusion and optoelectronic plethysmography, respectively. Plethysmographic and volometric measurements were made, before, during (at days 1, 4, 7, 14, 21, 26, 34 and 41), and after bedrest (days 1, 4, 7, 11 and 30 of the recovery period). Results showed a continuous decrease in leg volumes throughout bedrest, when VDI increased until day 26 of bedrest, and then decreased afterwards. The recovery period was characterized by a rapid return of VDI to prebedrest levels while leg volumes progressively normalised. These results showed that leg venous compliance changes are not always dependant upon skeletal muscle changes, and that factors other than size of muscle compartment are able to determine increases in leg venous compliance during long-term bedrest.     

Influence of graviceptives cues at different level of visual information processing: the effect of prolonged weightlessness

We evaluated the influence of prolonged weightlessness on the performance of visual tasks in the course of the Russian-French missions ANTARES, Post-ANTARES and ALTAIR aboard the MIR station. Eight cosmonauts were subjects in two experiments executed pre-flight, in-flight and post-flight sessions.

In the first experiment, cosmonauts performed a task of symmetry detection in 2-D polygons. The results indicate that this detection is locked in a head retinal reference frame rather than in an environmentally defined one as meridional orientations of symmetry axis (vertical and horizontal) elicited faster response times than oblique ones. However, in weightlessness the saliency of a retinally vertical axis of symmetry is no longer significantly different from an horizontal axis. In the second experiment, cosmonauts performed a mental rotation task in which they judged whether two 3-D objects presented in different orientations were identical. Performance on this task is basically identical in weightlessness and normal gravity.     

Simulation of a working process in the pulsejet engine with an aerodynamic valve on the basis of the thermodynamic cycle analysis

A physical and a mathematical model of a working process in the pulsejet engine based on the analysis of the thermodynamic cycle are proposed. The process of self-sustained periodic combustion is connected with special features of elementary processes comprising the cycle, influencing the engine operation and depending on its design parameters. The calculation method is based on the use of fundamental laws of conservation and basic equations of gas dynamics     

Experimental Aspects of Mid-Frequency Pulsations (f≈10–100 mHz) in the Southern Polar Cap

We review the results obtained in the frequency range of Pc3 (22-100 mHz) and Pc4 (7-22 mHz) pulsations at Italian Antarctic stations in the southern polar cap (“Mario Zucchelli”, at Terra Nova Bay, TNB, 80^˚.S; “Concordia”, the Italian/French base at Dome C, DMC, 89^˚.S). The absence of a midnight enhancement in the pulsation power suggests a negligible substorm influence at extreme latitudes, while the sharp noon enhancement, which appears only at TNB, is determined by the closer proximity of the station to cusp related phenomena. The relationship between the frequency of the band-limited signals and the interplanetary magnetic field strength, the cone angle influence, and the higher correlation of the Pc3 power with the solar wind speed in the morning hours suggest a global scenario in which upstream waves would be mainly responsible for the mid-frequency activity in the polar cap. However, the polarization pattern is odd with respect to the predictions for tailward propagating modes.     

The atmosphere of Jupiter

Current information on the neutral atmosphere of Jupiter is reviewed, with approximately equal emphasis on composition and thermal structure on the one hand, and markings and dynamics on the other. Studies based on Pioneer 10 and 11 data are used to refine the atmospheric model. Data on the interior are reviewed for the information they provide on the deep atmosphere. The markings and dynamics are discussed with emphasis on qualitative relationships and analogies with phenomena in the Earth's atmosphere.Contribution No. 2652 of the Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, Calif. 91125, U.S.A.     

Instability and unsteadiness of aircraft wake vortices

This paper presents a review of theoretical and experimental results on stability and other unsteady properties of aircraft wakes. The basic mechanisms responsible for the propagation and the amplification of perturbation along vortices, namely the Kelvin waves and the cooperative instabilities, are first detailed. These two generic unsteady mechanisms are described by considering asymptotic linear stability analysis of model flows such as vortex filaments or Lamb–Oseen vortices. Extension of the linear analysis to more representative flows, using a biglobal stability approach, is also described. Experimental results obtained using LDV, hot wire and PIV in wind tunnels are presented and they are commented upon the light of theory.     

Specification and Performance of Passive Sonar Spectral Estimators

The application of existing estimation theory to the problem of specification and performance of passive sonar spectral estimators is considered. The classification function is addressed, so that the signal is assumed to be present, and so that the energy arrival angle is known. The spatial filter considered is a line array of M equally spaced omnidirectional hydrophones. Signal and ambient noise are both zero-mean, wide-sense, stationary Gaussian random processes that differ in their spatial correlation across the face of the array. The signal is a plane wave that can be made totally spacially corrected between array elements by inserting delays between sensors to invert the signal propagation delay. The noise correlation is a function of frequency, bandwidth, element separation, and the relative time delay between sensors. Under these assumptions, the Cramer-Rao lower bound is derived for the class of unbiased estimates of signal power in a narrow frequency band at the hydrophone in the presence of correlated ambient noise of known power. The bound is examined numerically, resulting in a threshold phenomenon with M that constitutes a new design consideration. In addition, there is a striking insensitivity to realistic values of ambient noise correlation, and there are ranges in signal-to-noise ratio for which one gains more by increasing M than by increasing the bandwidth-time product. Specific processors, including a new unbiased estimator when noise power is unknown, are developed.     

Radar Performance with Multipath Using the Complex Angle

The complex angle (CA) method for resolving a low angle target from its multipath signal is evaluated in the presence of system noise. It is shown that standard deviation improvements of around 3-to-1 can be achieved at a 20-dB signal-to-noise power ratio relative to a normal monopulse system without the CA. It is also shown that the CA method is unbiased, giving bias improvements of as much as 100 times relative to normal monopulse. Evaluation of the assumptions in the technique shows very little sensitivity to knowledge of the reflecting surface's conductivity or dielectric constant. However, the method is somewhat sensitive to knowledge of surface roughness.