Towards Synthesis of Solar Wind and Geomagnetic Scaling Exponents: A Fractional Lévy Motion Model

Mandelbrot introduced the concept of fractals to describe the non-Euclidean shape of many aspects of the natural world. In the time series context, he proposed the use of fractional Brownian motion (fBm) to model non-negligible temporal persistence, the ‘Joseph Effect’; and Lévy flights to quantify large discontinuities, the ‘Noah Effect’. In space physics, both effects are manifested in the intermittency and long-range correlation which are by now well-established features of geomagnetic indices and their solar wind drivers. In order to capture and quantify the Noah and Joseph effects in one compact model, we propose the application of the ‘bridging’ fractional Lévy motion (fLm) to space physics. We perform an initial evaluation of some previous scaling results in this paradigm, and show how fLm can model the previously observed exponents. We suggest some new directions for the future.     

Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity—Results of an in vitro experiment on board of the Shenzhou-8 space mission

During spaceflight the immune system is one of the most affected systems of the human body. During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal cells, the most important effector cells of the immune system. We analyzed the effect of long-term microgravity on the cytoskeleton and immunologically relevant surface molecules. Human U937 cells were differentiated into a macrophageal phenotype and exposed to microgravity or 1g on a reference centrifuge on-orbit for 5 days. After on-orbit fixation, the samples were analyzed with immunocytochemical staining and confocal microscopy after landing. The unmanned Shenzhou-8 spacecraft was launched on board a Long March 2F (CZ-2F) rocket from the Jiuquan Satellite Launch Center (JSLC) and landed after a 17-day-mission. We found a severely disturbed actin cytoskeleton, disorganized tubulin and distinctly reduced expression of CD18, CD36 and MHC-II after the 5 days in microgravity. The disturbed cytoskeleton, the loss of surface receptors for bacteria recognition, the activation of T lymphocytes, the loss of an important scavenger receptor and of antigen-presenting molecules could represent a dysfunctional macrophage phenotype. This phenotype in microgravity would be not capable of migrating or recognizing and attacking pathogens, and it would no longer activate the specific immune system, which could be investigated in functional assays. Obviously, the results have to be interpreted with caution as the model system has some limitations and due to numerous technical and biological restrictions (e.g. 23 °C and no CO₂ supply during in-flight incubation). All parameter were carefully pre-tested on ground. Therefore, the experiment could be adapted to the experimental conditions available on Shenzhou-8.     

Characterization of a novel miniature cell culture device

Recent advancements in the field of microfluidics have generated much interest in the advent of a miniaturized cell culture device. In this study, we developed a novel miniature culture system for the continuous long-term cultivation of both anchorage dependent and suspension cells, either prokaryotic or eukaryotic in type, for both 1 g and microgravity applications. The miniature culture system may advance the development of microanalytical remote monitoring tools such as biological sentinels, biosensors, and lab-on-a-chip. Integrating the autonomous miniature culture system with a microanalytical device makes a powerful biological tool. Cells can be cultured long-term, harvested, and released directly into an analytical tool without the need for human interaction through fluid dynamic manipulations. This work characterizes the miniature bioreactor system through numerical and experimental proof of concept studies.     

Autonomous orbit maintenance system

Orbit maintenance is a major cost factor for Earth satellites in specialized orbits, such as a repeating ground track, or in formations. While autonomous attitude control is well established, the spacecraft's orbit is usually uncontrolled or maintained by ground station commands. For small, lower cost satellites, operations costs can be a dominant element of both cost and risk. This implies a need for low-cost autonomous orbit maintenance in order to allow such systems to be economically viable, particularly in today's constrained budget environment.

In addition, if the position of the spacecraft is controlled, it is therefore known in advance. Thus, mission planning can be done as far in advance as desired, without the need for replanning and frequent updating due to unpredictable orbit decay. An interesting characteristic of autonomous orbit maintenance is that it typically requires less software, and less complex software, than does orbit control from the ground. In many cases, an onboard orbit propagator is not needed.