Signal transduction in T lymphocytes--a comparison of the data from space, the free fall machine and the random positioning machine.

In this paper we discuss the effect of microgravity on T cells and we present the data of studies with two new machines for 0 g simulations. Several experiments in space show that mitogenic T cell activation is lost at 0 g. Immunocytochemistry indicates that such effect is associated with changes of the cytoskeleton. Biochemical studies suggest that the lack of expression of the interleukin-2 receptor is one of the major causes of the loss of activity. In fact, interleukin-2 is the third signal required for full activation. In order to deepen our investigations we are now working with the free-fall machine, FFM, invented by D. Mesland, and with the random positioning machine, RPM, or three-dimensional clinostat, developed by T. Hoson. The FFM produces periods of free-fall lasting approximately 800 ms followed by bounces of 15-30 g lasting 45-60 ms. The RPM eliminates the effect of gravity by rotating biological specimen randomly around two orthogonal axes. While the FFM failed to reproduce the results obtained with T lymphocytes in space, the data from the RPM are in good agreement with those in real microgravity. In fact, the inhibition of the mitotic index in the RPM is 89% compared to static controls. The RPM (as the FFM) can carry markedly larger specimen than the fast rotating clinostat and thus allows to conduct comprehensive studies to select suitable biological objects for further investigations in space.     

Protein crystal growth--microgravity aspects.

Protein crystals, grown under reduced gravity conditions, are either superior or inferior in their structural perfection than their Earth-grown counterparts. A reduction of the crystals' quality due to low-gravity effects on the growth processes cannot be understood from existing models. In this paper we put forth a rationale which predicts either advantages or disadvantages of microgravity growth. This rationale is based on the changes in the effective solute and impurity supply rates in microgravity and their effects on the intrinsic growth rate fluctuations that arise from the coupling of bulk transport to nonlinear interfacial kinetics and cause severe inhomogeneities. Depending on the specific diffusivity and kinetic coefficient of a protein and the impurities in the solution, either transport enhancement through forced flow or transport suppression under reduced gravity can result in a reduction of the kinetic fluctuations and, thus, growth with higher structural perfection. Investigating this mechanism of microgravity effects, we first demonstrate a one-to-one correspondence between these fluctuations, that are due to the bunching of growth steps, and the formation of defects in the crystals. We have confirmed the forced flow aspects of this rationale in ground-based experiments with lysozyme utilizing flowing solutions with varying, well characterized impurity contents.     

Satellite dynamics under the influence of gravitational and aerodynamic torques. A study of stability of equilibrium positions

The dynamics of the rotational motion of a satellite, moving in the central Newtonian force field under the influence of gravitational and aerodynamic torques, is investigated. The paper proposes a method for determining all equilibrium positions (equilibrium orientations) of a satellite in the orbital coordinate system for specified values of aerodynamic torque and the major central moments of inertia; the sufficient conditions for their existence are obtained. For each equilibrium orientation the sufficient stability conditions are obtained using the generalized energy integral as the Lyapunov function. The detailed numerical analysis of the regions where the stability conditions of the equilibrium positions are satisfied is carried out depending on four dimensionless parameters of the problem. It is shown that, in the general case, the number of satellite’s equilibrium positions, for which the sufficient stability conditions are satisfied, varies from 4 to 2 with an increase in the value of the aerodynamic torque magnitude.     

Statistical study of interplanetary condition effect on geomagnetic storms: 2. Variations of parameters

We investigate the behavior of mean values of the solar wind’s and interplanetary magnetic field’s (IMF) parameters and their absolute and relative variations during the magnetic storms generated by various types of the solar wind. In this paper, which is a continuation of paper [1], we, on the basis of the OMNI data archive for the period of 1976–2000, have analyzed 798 geomagnetic storms with D _st ≤ −50 nT and their interplanetary sources: corotating interaction regions CIR, compression regions Sheath before the interplanetary CMEs; magnetic clouds MC; “Pistons” Ejecta, and an uncertain type of a source. For the analysis the double superposed epoch analysis method was used, in which the instants of the magnetic storm onset and the minimum of the D _st index were taken as reference times. It is shown that the set of interplanetary sources of magnetic storms can be sub-divided into two basic groups according to their slowly and fast varying characteristics: (1) ICME (MC and Ejecta) and (2) CIR and Sheath. The mean values, the absolute and relative variations in MC and Ejecta for all parameters appeared to be either mean or lower than the mean value (the mean values of the electric field E _y and of the B _z component of IMF are higher in absolute value), while in CIR and Sheath they are higher than the mean value. High values of the relative density variation sN/〈N〉 are observed in MC. At the same time, the high values for relative variations of the velocity, B _z component, and IMF magnitude are observed in Sheath and CIR. No noticeable distinctions in the relationships between considered parameters for moderate and strong magnetic storms were observed.     

Probing the first stars and black holes in the early Universe with the Dark Ages Radio Explorer (DARE)

A concept for a new space-based cosmology mission called the Dark Ages Radio Explorer (DARE) is presented in this paper. DARE’s science objectives include: (1) When did the first stars form? (2) When did the first accreting black holes form? (3) When did Reionization begin? (4) What surprises does the end of the Dark Ages hold (e.g., Dark Matter decay)? DARE will use the highly-redshifted hyperfine 21-cm transition from neutral hydrogen to track the formation of the first luminous objects by their impact on the intergalactic medium during the end of the Dark Ages and during Cosmic Dawn (redshifts z = 11–35). It will measure the sky-averaged spin temperature of neutral hydrogen at the unexplored epoch 80–420 million years after the Big Bang, providing the first evidence of the earliest stars and galaxies to illuminate the cosmos and testing our models of galaxy formation. DARE’s approach is to measure the expected spectral features in the sky-averaged, redshifted 21-cm signal over a radio bandpass of 40–120 MHz. DARE orbits the Moon for a mission lifetime of 3 years and takes data above the lunar farside, the only location in the inner solar system proven to be free of human-generated radio frequency interference and any significant ionosphere. The science instrument is composed of a low frequency radiometer, including electrically-short, tapered, bi-conical dipole antennas, a receiver, and a digital spectrometer. The smooth frequency response of the antennas and the differential spectral calibration approach using a Markov Chain Monte Carlo technique will be applied to detect the weak cosmic 21-cm signal in the presence of the intense solar system and Galactic foreground emissions.     

Detonation engine fed by acetylene–oxygen mixture

The advantages of a constant volume combustion cycle as compared to constant pressure combustion in terms of thermodynamic efficiency has focused the search for advanced propulsion on detonation engines. Detonation of acetylene mixed with oxygen in various proportions is studied using mathematical modeling. Simplified kinetics of acetylene burning includes 11 reactions with 9 components. Deflagration to detonation transition (DDT) is obtained in a cylindrical tube with a section of obstacles modeling a Shchelkin spiral; the DDT takes place in this section for a wide range of initial mixture compositions. A modified ka-omega turbulence model is used to simulate flame acceleration in the Shchelkin spiral section of the system. The results of numerical simulations were compared with experiments, which had been performed in the same size detonation chamber and turbulent spiral ring section, and with theoretical data on the Chapman–Jouguet detonation parameters.     

On the Optimum Design of PCM Signals with System Constraints

This paper considers the design of PCM signals with system constraints using Pontryagin's maximum principle. The transmitter signal as well as the correlation signal are determined while maximizing the output signal-to-noise ratio. Both the single and three-pole transmitter filters are considered. An upper bound has been obtained on the performance of PCM signals with constraints.     

Investigation of CME properties using the data of SDO and PROBA2 spacecraft

Formation and motion (at the initial stage) of six limb CMEs detected in the period June 2010 to June 2011 are investigated using the high-resolution data of the PROBA2 and SDO spacecraft combined with the data of SOHO/LASCO coronagraphs. It is demonstrated that several loop-like structures of enhanced brightness originate in the region of CME formation, and they move one after another with, as a rule, different velocities. These loop-like structures in the final analysis form the frontal structure of CME. Time dependences of the velocity and acceleration of the ejection’s front are obtained for all CMEs under consideration. A conclusion is drawn about possible existence of two classes of CMEs depending on their velocity time profiles. Ejections, whose velocity after reaching its maximum sharply drops by a value of more than 100 km/s and then goes over into a regime of slow change, belong to the first class. Another class of CMEs is formed by ejections whose velocity changes slowly immediately after reaching the maximum. It is demonstrated that the CME’s angular dimension increases at the initial stage of ejection motion up to a factor of 3 with a time scale of doubling the angular size value within the limits 3.5–11 min since the moment of the first measurement of this parameter of an ejection. For three CMEs it is shown that at the initial stage of their motion for a certain time interval they are stronger expanded than grow in the longitude direction.     

Thermodynamic properties of mixed fuel combustion products

In this paper, the results of calculating the processes of two fuel mixture combustion in different proportions are presented. The values of temperature, thermal capacity, specific gas constant and isentropic expansion ratio of combustion products are given. Also shown is the distinction of thermodynamic properties from the additivity law.