Radiation biodosimetry: applications for spaceflight.

The multiparametric dosimetry system that we are developing for medical radiological defense applications could be adapted for spaceflight environments. The system complements the internationally accepted personnel dosimeters and cytogenetic analysis of chromosome aberrations, considered the best means of documenting radiation doses for health records. Our system consists of a portable hematology analyzer, molecular biodosimetry using nucleic acid and antigen-based diagnostic equipment, and a dose assessment management software application. A dry-capillary tube reagent-based centrifuge blood cell counter (QBC Autoread Plus, Becton [correction of Beckon] Dickinson Bioscience) measures peripheral blood lymphocytes and monocytes, which could determine radiation dose based on the kinetics of blood cell depletion. Molecular biomarkers for ionizing radiation exposure (gene expression changes, blood proteins) can be measured in real time using such diagnostic detection technologies as miniaturized nucleic acid sequences and antigen-based biosensors, but they require validation of dose-dependent targets and development of optimized protocols and analysis systems. The Biodosimetry Assessment Tool, a software application, calculates radiation dose based on a patient's physical signs and symptoms and blood cell count analysis. It also annotates location of personnel dosimeters, displays a summary of a patient's dosimetric information to healthcare professionals, and archives the data for further use. These radiation assessment diagnostic technologies can have dual-use applications supporting general medical-related care.     

Development of a Digital Array Radar (DAR)

Twenty-first century littoral and open-sea missions present US Navy (USN) shipboard-radar systems with the challenge of detecting small targets in severe clutter and against multiple sources of interference. In Fiscal Year 2000 (FY00), the Office of Naval Research (ONR) sponsored a program to develop an active array radar that includes a digital beamforming (DBF) architecture. The DBF radar system has the potential for improved time-energy management, improved signal-to-clutter (S/C) ratios, improved reliability and reduced life-cycle costs. This paper summarizes the latest developments of the program during FY00     

Asynchronous router specification

We describe the application of three formal design tools to a case study in the design of a distributed system. The case study in question involves the specification of an asynchronous message router; the three design tools are process algebra (specifically Milner's Calculus of Communicating Systems CCS), the modal μ-calculus and the Edinburgh Concurrency Workbench (CWB). We demonstrate how an informally-presented specification can be formalised within the language of the modal μ-calculus, allowing for a rigorous mathematical analysis of the correctness of our proposed implementation. For modest-sized versions of the router, this correctness proof has been carried out using the CWB     

Development of an advanced rocket propellant handler's suit.

Most launch vehicles and satellites in the US inventory rely upon the use of hypergolic rocket propellants, many of which are toxic to humans. These fuels and oxidizers, such as hydrazine and nitrogen tetroxide have threshold limit values as low as 0.01 PPM. It is essential to provide space workers handling these agents whole body protection as they are universally hazardous not only to the respiratory system, but the skin as well. This paper describes a new method for powering a whole body protective garment to assure the safety of ground servicing crews. A new technology has been developed through the small business innovative research program at the Kennedy Space Center. Currently, liquid air is used in the environmental control unit (ECU) that powers the propellant handlers suit (PHE). However, liquid air exhibits problems with attitude dependence, oxygen enrichment, and difficulty with reliable quantity measurement. The new technology employs the storage of the supply air as a supercritical gas. This method of air storage overcomes all of three problems above while maintaining high density storage at relatively low vessel pressures (<7000 kPa or approximately 1000 psi). A one hour prototype ECU was developed and tested to prove the feasibility of this concept. This was upgraded by the design of a larger supercritical dewar capable of holding 7 Kg of air, a supply which provides a 2 hour duration to the PHE. A third version is being developed to test the feasibility of replacing existing air cooling methodology with a liquid cooled garment for relief of heat stress in this warm Florida environment. Testing of the first one hour prototype yielded data comparable to the liquid air powered predecessor, but enjoyed advantages of attitude independence and oxygen level stability. Thermal data revealed heat stress relief at least as good as liquid air supplied units. The application of supercritical air technology to this whole body protective ensemble marked an advancement in the state-of-the-art in personal protective equipment. Not only was long duration environmental control provided, but it was done without a high pressure vessel. The unit met human performance needs for attitude independence, oxygen stability and relief of heat stress. This supercritical air (and oxygen) technology is suggested for microgravity applications in life support such as the Extravehicular Mobility Unit.     

Population dynamics of transgenic microorganisms in the different microecosystem conditions.

The role of key environmental factors in adaptation of spore-forming and non-spore-forming transgenic microorganisms (TM) have been studied in model ecosystems. Model TM Escherichia coli Z905 (bearing plasmid genes of bacterial luminescence Ap (r) Lux+) has been found to have a higher adaptation potential than TM Bacillus subtilis 2335/105 (bearing genes of human alpha 2-interferon Km (r) Inf+), planned for employment as a living vaccine under varying environmental conditions. Effects of abiotic factors on migration of natural and recombinant plasmids between microorganisms under model ecosystem conditions has been estimated. The transgenic microorganisms with low copy number survived better under introduction conditions in the microcosms studied. This trend has been shown to be independent of the microcosm type and its complexity. Grant numbers: 99-04-96017, 25, 00-07-9011.     

Energy storage at 77 K in multilayer ceramic capacitors

A ceramic material having a large dielectric constant at 77 K, ε=8000-12000, has been developed for capacitive energy storage at this temperature. A large matrix of multilayer ceramic capacitors were fabricated using conventional tape-casting methods to optimize the dielectric breakdown strength at 77 K, and measured energy storage values on these capacitors range up to 6 J/cm³ at 77 K. An unfused bank of these capacitors was voltage-cycled 10⁵ times at 77 K without failure, and the heating effects during cycling were immeasurably small (i.e., nitrogen boiloff was monitored). An electrocaloric effect on discharge (ΔT~1 K) contributes to the thermal stability. Measurements of the frequency dependence of the dielectric properties of the ceramic at 77 K indicate a fundamental limit of about 8 μs for the switching repetition rate. Improved capacitor-manufacturing methods are discussed which can increase the energy density to the 20-30 J/cm³ range     

Moving target imaging algorithm for SAR data

A digital processing algorithm for fine-resolution imaging of synthetic aperture radar (SAR) moving targets is described. The targets may have any translational and rotational motion components relative to the data collection platform. The algorithm requires the presence of up to three prominent points in the image of the target; the signals from these points provide estimates of the unknown target motion parameters. Phase compensation and data formatting based on these estimates eliminate motion-induced phase errors. This algorithm has been implemented on a VAX computer and used to process both simulated and real SAR data of moving targets. Results obtained using the simulated data are presented     

A recursive moving-target-indication algorithm for optical imagesequences

A recursive track-before-detect algorithm, producing potentially large signal-to-noise ratio (SNR) gains under realizable conditions, is described. The basic relation has the form of a linear, constant-coefficient difference equation with a unity magnitude damping factor. Known as recursive moving-target-indication (RMTI), this procedure adapts easily to digital processing and achieves SNR gains comparable to those from other robust track-before-detect algorithms. Examples are given to demonstrate the performance of the moving target indicator (MTI) procedure     

Intersatellite tracking methods for clustered geostationarysatellites

With the assumption that two satellites are placed in geostationary orbit at a small constant longitudinal separation, the feasibility of relative orbit determination by means of intersatellite tracking is studied analytically. Two types of tracking are examined: range-and-angle tracking and range-only tracking. Two-body orbital motion with first-order approximation of the relative orbital motion is assumed. The effect of solar radiation perturbation is evaluated numerically, and the study which neglects the perturbation is justified. The accuracy assessment of the relative orbit determination is given in general terms