Radiation biodosimetry: applications for spaceflight.

The multiparametric dosimetry system that we are developing for medical radiological defense applications could be adapted for spaceflight environments. The system complements the internationally accepted personnel dosimeters and cytogenetic analysis of chromosome aberrations, considered the best means of documenting radiation doses for health records. Our system consists of a portable hematology analyzer, molecular biodosimetry using nucleic acid and antigen-based diagnostic equipment, and a dose assessment management software application. A dry-capillary tube reagent-based centrifuge blood cell counter (QBC Autoread Plus, Becton [correction of Beckon] Dickinson Bioscience) measures peripheral blood lymphocytes and monocytes, which could determine radiation dose based on the kinetics of blood cell depletion. Molecular biomarkers for ionizing radiation exposure (gene expression changes, blood proteins) can be measured in real time using such diagnostic detection technologies as miniaturized nucleic acid sequences and antigen-based biosensors, but they require validation of dose-dependent targets and development of optimized protocols and analysis systems. The Biodosimetry Assessment Tool, a software application, calculates radiation dose based on a patient's physical signs and symptoms and blood cell count analysis. It also annotates location of personnel dosimeters, displays a summary of a patient's dosimetric information to healthcare professionals, and archives the data for further use. These radiation assessment diagnostic technologies can have dual-use applications supporting general medical-related care.     

Development of a Digital Array Radar (DAR)

Twenty-first century littoral and open-sea missions present US Navy (USN) shipboard-radar systems with the challenge of detecting small targets in severe clutter and against multiple sources of interference. In Fiscal Year 2000 (FY00), the Office of Naval Research (ONR) sponsored a program to develop an active array radar that includes a digital beamforming (DBF) architecture. The DBF radar system has the potential for improved time-energy management, improved signal-to-clutter (S/C) ratios, improved reliability and reduced life-cycle costs. This paper summarizes the latest developments of the program during FY00     

Competition of the natural and manmade biotic cycles in the closed aquatic system.

This study addresses competition between the Paramecium bursaria and zoochlorella-endosymbiosis and the infusoria Paramecium caudatum in a closed aquatic system. The system is a natural model of a simple biotic cycle. P. bursaria consumes glucose and oxygen released by its zoochlorella and releases nitrogenous compounds and carbon dioxide necessary for algal photosynthesis. P. caudatum was fed on bacteria. It was shown that the infusoria P. bursaria united in one cycle with Chlorella had a higher competitive ability than P. caudatum. With any initial percentage of the infusoria in the mixed culture, the end portion of P. bursaria reached 90-99%, which was significantly higher than the end potion of the P. caudatum population. It is assumed that the sustenance expenditures of P. caudatum were greater than those of the endosymbiotic paramecium, i.e. the closing of the components into a biotic cycle leads to a decrease in sustenance expenditures.     

Population dynamics of transgenic microorganisms in the different microecosystem conditions.

The role of key environmental factors in adaptation of spore-forming and non-spore-forming transgenic microorganisms (TM) have been studied in model ecosystems. Model TM Escherichia coli Z905 (bearing plasmid genes of bacterial luminescence Ap (r) Lux+) has been found to have a higher adaptation potential than TM Bacillus subtilis 2335/105 (bearing genes of human alpha 2-interferon Km (r) Inf+), planned for employment as a living vaccine under varying environmental conditions. Effects of abiotic factors on migration of natural and recombinant plasmids between microorganisms under model ecosystem conditions has been estimated. The transgenic microorganisms with low copy number survived better under introduction conditions in the microcosms studied. This trend has been shown to be independent of the microcosm type and its complexity. Grant numbers: 99-04-96017, 25, 00-07-9011.     

Moving target imaging algorithm for SAR data

A digital processing algorithm for fine-resolution imaging of synthetic aperture radar (SAR) moving targets is described. The targets may have any translational and rotational motion components relative to the data collection platform. The algorithm requires the presence of up to three prominent points in the image of the target; the signals from these points provide estimates of the unknown target motion parameters. Phase compensation and data formatting based on these estimates eliminate motion-induced phase errors. This algorithm has been implemented on a VAX computer and used to process both simulated and real SAR data of moving targets. Results obtained using the simulated data are presented     

A recursive moving-target-indication algorithm for optical imagesequences

A recursive track-before-detect algorithm, producing potentially large signal-to-noise ratio (SNR) gains under realizable conditions, is described. The basic relation has the form of a linear, constant-coefficient difference equation with a unity magnitude damping factor. Known as recursive moving-target-indication (RMTI), this procedure adapts easily to digital processing and achieves SNR gains comparable to those from other robust track-before-detect algorithms. Examples are given to demonstrate the performance of the moving target indicator (MTI) procedure     

Radar target identification using the bispectrum: a comparativestudy

Radar target identification is performed using time-domain bispectral features. The classification performance is compared with the performance of other classifiers that use either the impulse response or frequency domain response of the unknown target. The classification algorithms developed here are based on the spectral or the bispectral energy of the received backscatter signal. Classification results are obtained using simulated radar returns derived from measured scattering data from real radar targets. The performance of classifiers in the presence of additive Gaussian (colored or white), exponential noise, and Weibull noise are considered, along with cases where the azimuth position of the target is unknown. Finally, the effect on classification performance of responses horn extraneous point scatterers is investigated     

Ulysses solar wind observations to 56° south

In the 25 months since Jupiter flyby, the Ulysses spacecraft has climbed southward to a heliolatitude of 56°. This transit has been marked by an evolution from slow, dense coronal streamer belt solar wind through two regions where the rotation of the Sun carried Ulysses back and forth between streamer belt and polar coronal hole flows, and finally into a region of essentially continuous fast, low density solar wind from the southern polar coronal hole. Throughout these large changes, the momentum flux normalized to 1 AU displays very little systematic variation. In addition, the bulk properties of the polar coronal hole solar wind are quite similar to those observed in high speed streams in the ecliptic plane at 1 AU. Coronal mass ejections and forward and reverse shocks associated with corotating interaction regions have also been observed at higher heliolatitudes, however they are seen less frequently with increasing southern heliolatitude. Ulysses has thus far collected data from 20° of nearly contiguous solar wind flows from the polar coronal hole. We examine these data for characteristic variations with heliolatitude and find that the bulk properties in general show very little systematic variation across the southern polar coronal hole so far.     

A high performance automotive radar for automatic AICC

The paper describes a recent effort to design, build, and test a 77 GHz radar to be used for “intelligent” cruise control of automobiles. An analysis of requirements is given, design trade-offs are accounted for, and main features of prototypes in manufacturing are detailed. The radar has been thoroughly tested and evaluated both under “controlled” conditions and on roads, also in dense traffic. Results so far are very promising