Natriuretic peptide-sensitive guanylyl cyclase expression is down-regulated in human melanoma cells at simulated weightlessness

The membrane-bound guanylyl cyclases A and B (GC-A/B), which are receptors for natriuretic peptides, are expressed in cancer cells including melanomas and may represent new anticancer targets. Here, we report down-regulation of GC-A/B expression in human metastatic melanoma cells at simulated weightlessness in comparison to 1g conditions, suggesting attenuation of metastatic potential in weightlessness.     

Time profile of cosmic radiation exposure during the EXPOSE-E mission: the R3DE instrument

The aim of this paper is to present the time profile of cosmic radiation exposure obtained by the Radiation Risk Radiometer-Dosimeter during the EXPOSE-E mission in the European Technology Exposure Facility on the International Space Station's Columbus module. Another aim is to make the obtained results available to other EXPOSE-E teams for use in their data analysis. Radiation Risk Radiometer-Dosimeter is a low-mass and small-dimension automatic device that measures solar radiation in four channels and cosmic ionizing radiation as well. The main results of the present study include the following: (1) three different radiation sources were detected and quantified-galactic cosmic rays (GCR), energetic protons from the South Atlantic Anomaly (SAA) region of the inner radiation belt, and energetic electrons from the outer radiation belt (ORB); (2) the highest daily averaged absorbed dose rate of 426 μGy d(-1) came from SAA protons; (3) GCR delivered a much smaller daily absorbed dose rate of 91.1 μGy d(-1), and the ORB source delivered only 8.6 μGy d(-1). The analysis of the UV and temperature data is a subject of another article (Schuster et al., 2012 ).     

Challenges in the Measurement and Data-Processing Chain of the LISA Mission

The LISA Mission (Laser Interferometer Space Antenna) is currently under mission formulation with a launch date planned in 2020. The purpose of the mission is the observation of gravitational waves at frequencies between 0.1 mHz and 1 Hz by measuring distance fluctuations between inertial reference points, represented by cubic proof masses. In order to provide a sufficient sensitivity of the instrument, distance fluctuations between two inertial reference points must be measured with a strain accuracy of around 10^?20 Hz^?1/2. This is achieved by setting up a laser interferometer with a base-length of 5?10⁶ km and a path-length measurement noise in the order of 10 pm?Hz^?1/2. For a correct evaluation of the data on the ground, it is essential that the science data telemetry preserves all required frequency domain information. That is, any on-board data-processing and down-sampling must be done with great care in order not to introduce aliasing or other artifacts into the data stream. As an additional complication, most of the optical metrology data is dominated by laser phase noise which is about eight orders of magnitude larger than the required instrument sensitivity. However, by applying a method called “time-delayed interferometry” during the ground data processing, this laser phase noise can be eliminated from the data. This method has already been demonstrated in a detailed simulation environment, but it requires a very careful filtering, synchronization, and interpolation of the individual data streams. Last but not least, a calibration of system parameters is necessary in many areas of the LISA measurement system. The system design must therefore ensure that all data required for these calibrations is available on-ground in a quality that allows a successful computation of the calibration coefficients within a reasonable time-frame. The data streams do not only include data from the optical metrology system, but also from the drag-free and attitude control system which are used to derive other information, such as the charge state of the proof mass. This yields a strong coupling between the different disciplines since data that is only used for housekeeping purposes in other missions becomes an essential part of the science data stream for the LISA mission. This paper gives an overview of the LISA measurement and data-processing chain. It highlights the most challenging areas that have been identified so far and describes the intended solution methods.     

ESA ministerial meeting: consensus or confrontation?

This article looks at the issues facing the ESA ministerial meeting in November 1991. The background to European space collaboration is outlined and the current position on the Hermes and Columbus programmes is described. The financial overrun of the Hermes programme is referred to and set in the context of the overall financial problems facing the ministers. Finally, possible areas of saving are highlighted.     

Optimal control of the Shuttle-Tethered-Subsatellite system

Alternate control laws based on an application of the linear regulator problem are developed for possible use in the operation of the Shuttle-Tethered-Subsatellite system. Control is assumed to be provided only by modulating the tension level in the tether as a function of the difference between actual and commanded tether line length, length rate, in (orbital) plane swing angle and swing angle rate. Necessary and sufficient conditions for stability of the (linear) system motion in the vicinity of its nominal local vertical orientation are developed. By proper selection of the state and control penalty matrices it is possible to obtain faster responses with no increase in maximum power levels for use in station keeping when compared with alternate control strategies. The weighting matrices are adjusted in a piecewise adaptive manner to provide control law gains in order to achieve a smooth deployment history. Successful retrievel is dependent mainly on the initial conditions and the rate at which the commanded length is reduced.     

IUE observations of hot stars

Stellar winds are found in hot and luminous stars of all types. We see evidence of these winds in P Cygni profiles of resonance lines in the UV spectral regions, and obtain density information from them, and from optical emission lines and from free-free radiation in the infrared and radio continua from the ionized plasma. Data recently acquired from the IUE satellite are now sufficient to enable us to outline the broad parameters of these winds. It is found that for the hottest stars, those of 0-type, the mass loss rate ? is proportional to L^α. A proportionality between ? and L is predicted by the theory of radiatively driven winds; the value for α is also anticipated by the details of the theory. The dispersion of individual stellar values may be due to observational uncertainty alone, but it may also suggest that other physical parameters affect the stellar winds. The kinetic energy input of the stellar winds to the interstellar medium is considerable and may, in aggregate, be of the same order as the contribution of supernovae.