Influence of gravity on the circadian timing system.

The circadian timing system (CTS) is responsible for daily temporal coordination of physiological and behavioral functions both internally and with the external environment. Experiments in altered gravitational environments have revealed changes in circadian rhythms of species ranging from fungi to primates. The altered gravitational environments examined included both the microgravity environment of spaceflight and hyperdynamic environments produced by centrifugation. Acute exposure to altered gravitational environments changed homeostatic parameters such as body temperature. These changes were time of day dependent. Exposure to gravitational alterations of relatively short duration produced changes in both the homeostatic level and the amplitude of circadian rhythms. Chronic exposure to a non-earth level of gravity resulted in changes in the period of the expressed rhythms as well as in the phase relationships between the rhythms and between the rhythms and the external environment. In addition, alterations in gravity appeared to act as a time cue for the CTS. Altered gravity also affected the sensitivity of the pacemaker to other aspects of the environment (i.e., light) and to shifts of time cues. Taken together, these studies lead to the conclusion that the CTS is indeed sensitive to gravity and its alterations. This finding has implications for both basic biology and space medicine.     

Control of microorganisms in flowing nutrient solutions.

Controlling microorganisms in flowing nutrient solutions involves different techniques when targeting the nutrient solution, hardware surfaces in contact with the solution, or the active root zone. This review presents basic principles and applications of a number of treatment techniques, including disinfection by chemicals, ultrafiltration, ultrasonics, and heat treatment, with emphasis on UV irradiation and ozone treatment. Procedures for control of specific pathogens by nutrient solution conditioning also are reviewed.     

Infrared spectrometer PFS for the Mars 94 orbiter

Thin films containing a mixture of aliphatic (glycine) and aromatic (tryptophan or tyrosine) amino acids were exposed to a vacuum ultraviolet radiation (VUV) with wavelenghts 100–200 nm. Dipeptides (glycyl-tryptophan and glycyl-tyrosine) were synthesized in these conditions. We compared the actions of VUV and γ-radiation. Polymerization is an essential step in prebiological evolution and we have shown that this stage probably occured over an early Solar system history.     

Long-term modulation of Galactic Cosmic Radiation and its model for space exploration.

As the human exploration of space has received new attention in the United States, studies find that exposure to space radiation could adversely impact the mission design. Galactic Cosmic Radiation (GCR), with its very wide range of charges and energies, is particularly important for a mission to Mars, because it imposes a stiff mass penalty for spacecraft shielding. Dose equivalent versus shielding thickness calculations, show a rapid initial drop in exposure with thickness, but an asymptotic behavior at a higher shielding thickness. Uncertainties in the radiobiology are largely unknown. For a fixed radiation risk, this leads to large uncertain ties in shielding thickness for small uncertainties in estimated dose. In this paper we investigate the application of steady-state, spherically-symmetric diffusion-convection theory of solar modulation to individual measurements of differential energy spectra from 1954 to 1989 in order to estimate the diffusion coefficient, kappa (r,t), as a function of time. We have correlated the diffusion coefficient to the Climax neutron monitor rates and show that, if the diffusion coefficient can be separated into independent functions of space and time: kappa (-r,t)=K(t)kappa 0 beta P kappa 1(r), where beta is the particle velocity and P the rigidity, then (i) The time dependent quantity 1/K(t), which is proportional to the deceleration potential, phi(r,t), is linearly related to the Climax neutron monitor counting rate. (ii) The coefficients obtained from hydrogen or helium intensity measurements are the same. (iii) There are different correlation functions for odd and even solar cycles. (iv) The correlation function for the Climax neutron monitor counting rate for given time, t, can be used to estimate mean deceleration parameter phi(t) to within +/- 15% with 90% confidence. We have shown that kappa(r,t) determined from hydrogen and/or helium data, can be used to fit the oxygen and iron differential energy spectra with a root mean square error of about +/- 10%, and essentially independent of the particle charge or energy. We have also examined the ion chamber and 14C measurements which allow the analysis to be extended from the year 1906 to 1990. Using this model we have defined reference GCR spectra at solar minimum and solar maximum. These can be used for space exploration studies and provide a quantitative estimate of the error in dose due to changes in GCR intensities.     

The Indian Space Program

The Indian Space Program is described. The main objectives of the program are to provide operation space services to the nation, especially in the fields of communications and remote sensing, and to use modern space technology for the benefit of the Indian people. Some applications of the Indian Space Program are remote sensing, imagery, communications, broadcasting, and surveys of natural resources for water, crop, forest, land, minerals, and ocean. The emphasis is on the development and operation of indigenous satellites and launch vehicles for providing these space services     

The status of qualification of a new separator system for advancedaerospace battery cells

A nickel cadmium cell system which utilizes a polypropylene separator impregnated with polybenzimadazole, and which shows promise of providing an aerospace battery with performance equivalent to Super NiCd, and yet is more cost effective, is described. Background information, cell construction information, detailed test program information and data, and status of qualification are given     

Crustaceans as a model for microgravity-induced muscle atrophy.

Atrophy of skeletal muscles is a serious problem in a microgravity environment. It is hypothesized that the unloading of postural muscles, which no longer must resist gravity force, causes an accelerated breakdown of contractile proteins, resulting in a reduction in muscle mass and strength. A crustacean model using the land crab, Gecarcinus lateralis, to assess the effects of spaceflight on protein metabolism is presented. The model is compared to a developmentally-regulated atrophy in which a premolt reduction in muscle mass allows the withdrawal of the large claws at molt. The biochemical mechanisms underlying protein breakdown involves both Ca(2+)-dependent and multicatalytic proteolytic enzymes. Crustacean claw muscle can be used to determine the interactions between shortening and unloading at the molecular level.     

Monte Carlo track structure studies of energy deposition and calculation of initial DSB and RBE.

Estimation of exposure due to environmental and other sources of radiations of high-LET and low-LET is of interest in radiobiology and radiation protection for risk assessment. To account for the differences in effectiveness of different types of radiations various parameters have been used. However, the relative inadequacy of the commonly used parameters, including dose, fluence, linear energy transfer, lineal energy, specific energy and quality factor, has been made manifest by the biological importance of the microscopic track structure and primary modes of interaction. Monte Carlo track structure simulations have been used to calculate the frequency of energy deposition by radiations of high- and low-LET in target sizes similar to DNA and higher order genomic structure. Tracks of monoenergetic heavy ions and electrons were constructed by following the molecular interaction-by-interaction histories of the particles down to 10 eV. Subsequently, geometrical models of these assumed biological targets were randomly exposed to the radiation tracks and the frequency of energy depositions obtained were normalized to unit dose in unit density liquid water (l0(3) kg m-3). From these data and a more sophisticated model of the DNA, absolute yields of both single- and double-strand breaks expressed in number of breaks per dalton per Gray were obtained and compared with the measured yields. The relative biological effectiveness (RBE) for energy depositions in cylindrical targets has been calculated using 100 keV electrons as the reference radiation assuming the electron track-ends contribution is similar to that in 250 kV X-ray or Co60 gamma-ray irradiations.     

Satellite observations of sea ice

An overview is presented of Antarctic and Arctic sea ice studies using data from the Nimbus-5 ESMR and the Nimbus-7 SMMR passive microwave radiometers. Four years (1973–1976) of ESMR data for the Antarctic Ocean define the characteristics of the seasonal cycle including regional contrasts and interannual variations. Major advances include the discovery of the Weddell polynya and the presence of substantial areas of open water in the Antarctic winter pack ice. Regional differences in sea ice extent on time-scales of about a month are shown to be associated with variations in surface-wind fields. In the Arctic, the computation of sea ice concentration is complicated by the presence of multiyear ice, but the amount of multiyear ice becomes an important measurable quantity with dual-polarized, multifrequency passive microwave sensors. Analysis of SMMR data demonstrates its advantage for studying the spatial and temporal variability of the Arctic ice cover. Large observed interannual variations in the distribution of the multiyear pack ice and the presence of significant divergent areas in the central Arctic during winter contrast markedly with the classical view of the Arctic pack ice.