Radiation biodosimetry: applications for spaceflight.

The multiparametric dosimetry system that we are developing for medical radiological defense applications could be adapted for spaceflight environments. The system complements the internationally accepted personnel dosimeters and cytogenetic analysis of chromosome aberrations, considered the best means of documenting radiation doses for health records. Our system consists of a portable hematology analyzer, molecular biodosimetry using nucleic acid and antigen-based diagnostic equipment, and a dose assessment management software application. A dry-capillary tube reagent-based centrifuge blood cell counter (QBC Autoread Plus, Becton [correction of Beckon] Dickinson Bioscience) measures peripheral blood lymphocytes and monocytes, which could determine radiation dose based on the kinetics of blood cell depletion. Molecular biomarkers for ionizing radiation exposure (gene expression changes, blood proteins) can be measured in real time using such diagnostic detection technologies as miniaturized nucleic acid sequences and antigen-based biosensors, but they require validation of dose-dependent targets and development of optimized protocols and analysis systems. The Biodosimetry Assessment Tool, a software application, calculates radiation dose based on a patient's physical signs and symptoms and blood cell count analysis. It also annotates location of personnel dosimeters, displays a summary of a patient's dosimetric information to healthcare professionals, and archives the data for further use. These radiation assessment diagnostic technologies can have dual-use applications supporting general medical-related care.     

Energy and charge localization in irradiated DNA.

The relation between the site of energy deposition and the site of its biological action is an important question in radiobiology. Even at 77 degrees K, evidence is clear that these two sites must be separated since energy deposition is random but specific products are formed. Several processes that may contribute to this separation are: 1) hole migration and stabilization through deprotonation to give neutral oxidation product radicals; 2) electron trapping and transfer to form specific radical anions, possibly followed by protonation to give neutral reduction product radicals; and 3) recombination of spatially separated charges or radicals. These microscopic processes will be reviewed critically in an analysis using electron paramagnetic resonance spectroscopy (EPR) evidence for and against long-range transfer of energy and/or charge in frozen, hydrated DNA.     

SWE,a comprehensive plasma instrument for the WIND spacecraft

The Solar Wind Experiment (SWE) on the WIND spacecraft is a comprehensive, integrated set of sensors which is designed to investigate outstanding problems in solar wind physics. It consists of two Faraday cup (FC) sensors; a vector electron and ion spectrometer (VEIS); a strahl sensor, which is especially configured to study the electron strahl close to the magnetic field direction; and an on-board calibration system. The energy/charge range of the Faraday cups is 150 V to 8 kV, and that of the VEIS is 7 V to 24.8 kV. The time resolution depends on the operational mode used, but can be of the order of a few seconds for 3-D measurements. Key parameters which broadly characterize the solar wind positive ion velocity distribution function will be made available rapidly from the GGS Central Data Handling Facility.     

The Cassini Visual And Infrared Mapping Spectrometer (Vims) Investigation

The Cassini visual and infrared mapping spectrometer (VIMS) investigation is a multidisciplinary study of the Saturnian system. Visual and near-infrared imaging spectroscopy and high-speed spectrophotometry are the observational techniques. The scope of the investigation includes the rings, the surfaces of the icy satellites and Titan, and the atmospheres of Saturn and Titan. In this paper, we will elucidate the major scientific and measurement goals of the investigation, the major characteristics of the Cassini VIMS instrument, the instrument calibration, and operation, and the results of the recent Cassini flybys of Venus and the Earth–Moon system.This revised version was published online in July 2005 with a corrected cover date.     

SAR ATR performance using a conditionally Gaussian model

A family of conditionally Gaussian signal models for synthetic aperture radar (SAR) imagery is presented, extending a related class of models developed for high resolution radar range profiles. This signal model is robust with respect to the variations of the complex-valued radar signals due to the coherent combination of returns from scatterers as those scatterers move through relative distances on the order of a wavelength of the transmitted signal (target speckle). The target type and the relative orientations of the sensor, target, and ground plane parameterize the conditionally Gaussian model. Based upon this model, algorithms to jointly estimate both the target type and pose are developed. Performance results for both target pose estimation and target recognition are presented for publicly released data from the MSTAR program     

What is the threshold amount of starch necessary for full gravitropic sensitivity?

In preparation for microgravity experiments, we studied the kinetics of gravitropism in seedlings of wild-type (WT) Arabidopsis and three starch-deficient mutants. One of these mutants is starchless (ACG 21) while the other two are intermediate starch mutants (ACG 20 and ACG 27). In root cap cells, ACG 20 and 27 have 51% and 60% of the WT amount of starch, respectively. However, in endodermal cells of the hypocotyl, ACG 20 has a greater amount of starch than ACG 27. WT roots and hypocotyls were much more responsive to gravity than were the respective organs of the starchless mutant, and the intermediate starch mutants exhibited reduced gravitropism but had responses that were close to that of the WT. In roots, ACG 27 (more starch) was more responsive than ACG 20 (less starch), while in hypocotyls, ACG 20 (more starch) had a greater response than ACG 27 (less starch). Taken together, our data are consistent with the starch-statolith hypothesis for gravity perception in that the degree of graviresponsiveness is proportional to the total mass of plastids per cell. These results also suggest that (in roots) 51-60% starch is close to the threshold amount of starch needed for full gravitropism and that the gravity sensing system is "overbuilt."     

Nuclear fragmentation database for GCR transport code development

A critical need for NASA is the ability to accurately model the transport of heavy ions in the Galactic Cosmic Rays (GCR) through matter, including spacecraft walls, equipment racks, etc. Nuclear interactions are of great importance in the GCR transport problem, as they can cause fragmentation of the incoming ion into lighter ions. Since the radiation dose delivered by a particle is proportional to the square of (charge/velocity), fragmentation reduces the dose delivered by incident ions. The other mechanism by which dose can be reduced is ionization energy loss, which can lead to some particles stopping in the shielding. This is the conventional notion of shielding, but it is not applicable to human spaceflight since the particles in the GCR tend to be too energetic to be stopped in the relatively thin shielding that is possible within payload mass constraints. Our group has measured a large number of fragmentation cross sections, intended to be used as input to, or for validation of, NASA’s radiation transport models. A database containing over 200 charge-changing cross sections and over 2000 fragment production cross sections has been compiled. In this report, we examine in detail the contrast between fragment measurements at large acceptance and small acceptance. We use output from the PHITS Monte Carlo code to test our assumptions using as an example ⁴⁰Ar data (and simulated data) at a beam energy of 650 MeV/nucleon. We also present preliminary analysis in which isotopic resolution was attained for beryllium fragments produced by beams of ¹⁰B and ¹¹B. Future work on the experimental data set will focus on extracting and interpreting production cross sections for light fragments.     

Iridium(R) aeronautical satellite communications

The ever-increasing demand to stay in touch, to be able to communicate anywhere and anytime, has created a market for low Earth orbit (LEO) satellite communications services such as the Iridium system. The Iridium satellite communications network is being developed to support the needs of the passenger, the cabin crew and the flight crew for: aeronautical public correspondence (APC); aeronautical administrative communications (AAC); aeronautical operational control (AOC); and air traffic services (ATS)