Detection of microlesions induced by heavy ions using liposomes filled with fluorescent dye.

In cells irradiation by heavy ions has been hypothesized to produce microlesions, regions of local damage. In cell membranes this damage is thought to manifest itself in the form of holes. The primary evidence for microlesions comes from morphological studies of cell membranes, but this evidence is still controversial, especially since holes also have been observed in membranes of normal, nonirradiated, cells. However, it is possible that damage not associated with histologically discernable disruptions may still occur. In order to resolve this issue, we developed a system for detecting microlesions based on liposomes filled with fluorescent dye. We hypothesized that if microlesions form in these liposomes as the result of irradiation, then the entrapped dye will leak out into the surrounding medium in a measurable way. Polypropylene vials containing suspensions of vesicles composed of either dipalmitoyl phosphatidylcholine, or a combination of egg phosphatidylcholine and cholesterol were irradiated at the Brookhaven National Laboratory using 56Fe ions at 1 GeV/amu. In several cases we obtained a significant loss of the entrapped dye above the background level. Our results suggest that holes may form in liposomes as the result of heavy ion irradiation, and that these holes are large enough to allow leakage of cell internal contents that are at least as large as a 1 nm diameter calcein molecule.     

Analyses of exobiological and potential resource materials in the Martian soil.

Potential Martian soil components relevant to exobiology include water, organic matter, evaporites, clays, and oxides. These materials are also resources for human expeditions to Mars. When found in particular combinations, some of these materials constitute diagnostic paleobiomarker suites, allowing insight to be gained into the probability of life originating on Mars. Critically important to exobiology is the method of data analysis and data interpretation. To that end we are investigating methods of analysis of potential biomarker and paleobiomarker compounds and resource materials in soils and rocks pertinent to Martian geology. Differential thermal analysis coupled with gas chromatography is shown to be a highly useful analytical technique for detecting this wide and complex variety of materials.     

Stellar infrared astronomy with EDISON

In this review the IR emission from circumstellar material is discussed, both of ionized gas and dust grains, and the astrophysical information that can be extracted from such observations. Some emphasis is placed on the possibilities of stellar IR astronomy using a large space-borne telescope, especially with respect to the much better spatial and spectral resolution of such a telescope compared to the current generation of ground-based and space IR telescopes.     

Forecasting the 23 and 24 solar cycles on the basis of MGM spectrum

A new method of nonlinear spectral analysis (called the method of global minimum: MGM), based on the best presentation (in sense of minimal squares) of a given time data set as a sum of sinusoids whose frequencies, amplitudes and phases are to be determined, has been used to find periodicities in annual Wolf sunspot numbers (W) during the period 1700–1995. The possible future behaviour of the 11-year solar cycle (based on an extrapolation of the calculated model) is also presented. The main characteristics of the 23^rd solar cycle are as follows: the W maximum occurs about 2004, with a peak of nearly 220. An unusually large value of W will occur during the 23^rd cycle, which should be characterised by the longest maximum, specifically, W will be greater than 100 during the 11-year period from 1997 to 2007. The first sharp rise will occur during the period 1996–1998, the second sharp during 2002–2004. The main features of the 24 year cycle are as follows: the next minimum in W, associated with the 24^th solar cycle, should occur in the year 2008 and the maximum in 2014. W is expected to peak at about 180. The minimum value for the 25^th year cycle is expected to occur in the year 2019. It is shown that the accuracy of these predictions depends, first of all, on the extrapolation of the hyperlong harmonic of the calculated polyharmonic model fit of observed annual sunspot numbers during the period 1700–1995. The error bars in the definition of the maximum and minimum epochs can be as large as two years.     

Large lithium ion batteries for aerospace and aircraft applications

Eagle-Picher Energy Products (EPEP) has been manufacturing and testing large lithium ion cells (up to 100-Ah) for several years. Recently, work has focused on the testing of different chemistries at variable temperatures and designing and fabricating 100-Ah cylindrical cells. For the aircraft application the largest concern is irreversible capacity loss at elevated temperatures (70°C). In contrast, for the aerospace application shelf-life and cycle life are critical. EPEP has found that the major contributor to the loss in low temperature performance due to high temperature testing, was the positive electrode. EPEP discuss recent results of variable temperature cycling and 100-Ah cell performance     

Senrad: an advanced wideband air-surveillance radar

The generic characteristics and performance of an experimental long-range air-surveillance radar, known at the Naval Research Laboratory as Senrad, is described. Its distinguishing feature is that it can operate with simultaneous transmissions over a very wide bandwidth-from 850 to 1400 MHz. The technology and type of experimental radar equipment employed are discussed and examples are given of its performance capabilities obtained by means of very wideband operation. The unusually wide bandwidth of this radar allows 1) improved detection and tracking performance because of the absence of the nulls that are common in the antenna elevation radiation-pattern of a single-frequency radar; 2) moving target indication (MTI) without loss of targets due to blind speeds and without the need for multiple PRFs (pulse repetition frequencies); 3) accurate height finding with a fan-beam radar by taking advantage of the multipath time difference as a function of target height; 4) a form of limited target recognition based on high range-resolution; and 5) a reduction of the effectiveness of electronic countermeasures that can seriously degrade more narrowband radars     

Observer-type Kalman innovation filter for uncertain linear systems

An observer-type of Kalman innovation filtering algorithm to find a practically implementable "best" Kalman filter, and such an algorithm based on the evolutionary programming (EP) optima-search technique, are proposed, for linear discrete-time systems with time-invariant unknown-but-hounded plant and noise uncertainties. The worst-case parameter set from the stochastic uncertain system represented by the interval form with respect to the implemented "best" filter is also found in this work for demonstrating the effectiveness of the proposed filtering scheme. The new EP-based algorithm utilizes the global optima-searching capability of EP to find the optimal Kalman filter and state estimates at every iteration, which include both the best possible worst case Interval and the optimal nominal trajectory of the Kalman filtering estimates of the system state vectors. Simulation results are included to show that the new algorithm yields more accurate estimates and is less conservative as compared with other related robust filtering schemes     

Steady-state analysis and design of a switched-capacitor DC-DCconverter

A representative switched-capacitor DC-DC converter topology is presented, circuit operation is explained, and control strategies are identified. State-space averaging is used to analyze steady-state performance and to develop control criteria and design equations. The analytical results are verified by SPICE simulation