Effect of fluid and salt supplements in preventing the development of "osteopenia" in hypokinetic rats

It has been suggested that a daily intake of fluid and salt supplements may be used to prevent bone demineralization in human subjects after prolonged exposure to hypokinesia (diminished muscular activity). Thus, the objective of this investigation was to evaluate the effect of fluid and salt supplementation in the prevention of development of osteoporosis in 64 Wistar rats with an initial body weight of 339-345 g, after exposure to 90 days of hypokinesia. They divided into 4 equal groups: the first group of rats placed under ordinary vivarium conditions and served as vivarium control; the second group were also placed under ordinary vivarium conditions but received daily fluid and salt supplements; the third group were subjected to pure hypokinesia, i.e. without the use of any preventive measures; and the fourth group were submitted to hypokinesia and received daily fluid and salt supplements. For the simulation of the hypokinetic effect the experimental group of rats were kept in small, individual, wooden cages. Through the experimental period the second and fourth group of rats received 8 ml/100 g body wt water and 5 ml 100 g body wt NaCl daily. By the end of the experimental period the animals were decapitated and the spongy matter of tibia and vertebrae of the rats were examined for changes referable to osteoporosis. It was found that the daily intake of fluid and salt supplements caused an increase in the volume density of primary spongiosa of bones. It was concluded that a daily intake of fluid and salt supplements may be used to prevent the development of osteoporosis in rats subjected to prolonged motor activity restriction.     

Influence of the 2:1 resonance in the orbits of GPS satellites

Due to the characteristics of their orbits the GPS satellites are submitted to the following main perturbations: terrestrial gravitational field, luni-solar gravitational attraction and solar radiation pressure (including the effects of the Earth's shadow). An additional perturbation arises due to the 2:1 commensurability of the orbital period of the satellite with the period of the Earth's rotation. An analytical theory is briefly presented to solve the equations of motion including the previously mentioned effects. The analytical solution, based on the Lie-Hori method, is compared with a numerical integration of the equations.     

Inverse-compton gamma rays from plerions

Young pulsars surrounded by supernova remnants can power synchrotron nebulae through the injection of relativistic particles. Inverse Compton scattering by the high-energy electrons and positrons can produce TeV gamma-ray emission strong enough to be detectable by ground-based telescopes. The Crab nebula is the archetypical example of a gamma-ray plerion and was the first detected TeV source. The observed spectrum is consistent with predictions of synchrotron-self Compton models. This paper will review such models for the Crab and other plerions. Inverse-Compton scattering on other soft photon sources, particularly the 2.7K microwave background, may also be detectable in older remnants.     

The Role and Contributions of Energetic Neutral Atom (ENA) Imaging in Magnetospheric Substorm Research

Energetic Neutral Atom (ENA) imaging has contributed substantially to substorm research. This technique has allowed significant advances in areas such as observation and quantification of injected particle drift as a function of energy, observation of dynamics in the tail that are directly related to the effects of imposed (growth phase) and induced (expansion phase) electric fields on the plasma, the prompt extraction of oxygen from the ionosphere during substorms, the relationship between storms and substorms, and the timing of substorm ENA signatures. We present discussion of the advantages and shortcomings of the ENA technique for studying space plasmas. Although the technique is in its infancy, it is yielding results that enrich our understanding of the substorm process and its effects.     

Steady-state analysis and design of a switched-capacitor DC-DCconverter

A representative switched-capacitor DC-DC converter topology is presented, circuit operation is explained, and control strategies are identified. State-space averaging is used to analyze steady-state performance and to develop control criteria and design equations. The analytical results are verified by SPICE simulation     

Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

Design of the TRIO system-on-chip for aerospace

Several design and testing aspects of the TRIO smart sensor data acquisition chip, developed by JHU/APL for NASA spacecraft applications are presented. TRIO includes a 10 bit self-corrected analog-to-digital converter (ADC), 16/32 analog inputs, a front end multiplexer with selectable aquisition time, a current source, memory, serial and parallel bus, and control logic. So far TRIO is used in many missions including Contour, Messenger, Stereo, Pluto, and the generic JPL X2000 spacecraft bus.     

Raman imagery: a new approach to assess the geochemical maturity and biogenicity of permineralized precambrian fossils

Laser-Raman imagery is a non-intrusive, non-destructive analytical technique, recently introduced to Precambrian paleobiology, that can be used to demonstrate a one-to-one spatial correlation between the optically discernible morphology and kerogenous composition of permineralized fossil microorganisms. Made possible by the submicron-scale resolution of the technique and its high sensitivity to the Raman signal of carbonaceous matter, such analyses can be used to determine the chemical-structural characteristics of organic-walled microfossils and associated sapropelic carbonaceous matter in acid-resistant residues and petrographic thin sections. Here we use this technique to analyze kerogenous microscopic fossils and associated carbonaceous sapropel permineralized in 22 unmetamorphosed or little-metamorphosed fine-grained chert units ranging from approximately 400 to approximately 2,100 Ma old. The lineshapes of the Raman spectra acquired vary systematically with five indices of organic geochemical maturation: (1) the mineral-based metamorphic grade of the fossil-bearing units; (2) the fidelity of preservation of the fossils studied; (3) the color of the organic matter analyzed; and both the (4) H/C and (5) N/C ratios measured in particulate kerogens isolated from bulk samples of the fossil-bearing cherts. Deconvolution of relevant spectra shows that those of relatively well-preserved permineralized kerogens analyzed in situ exhibit a distinctive set of Raman bands that are identifiable also in hydrated organic-walled microfossils and particulate carbonaceous matter freed from the cherts by acid maceration. These distinctive Raman bands, however, become indeterminate upon dehydration of such specimens. To compare quantitatively the variations observed among the spectra measured, we introduce the Raman Index of Preservation, an approximate measure of the geochemical maturity of the kerogens studied that is consistent both with the five indices of organic geochemical alteration and with spectra acquired from fossils experimentally heated under controlled laboratory conditions. The results reported provide new insight into the chemical-structural characteristics of ancient carbonaceous matter, the physicochemical changes that accompany organic geochemical maturation, and a new criterion to be added to the suite of evidence by which to evaluate the origin of minute fossil-like objects of possible but uncertain biogenicity.     

Ginga observations of Seyfert galaxies

We observed twenty-eight Seyfert 2 galaxies with the Japanese X-ray satellite, Ginga, and found Seyfert 2 galaxies, in general, have the X-ray spectral characteristics of obscured Seyfert 1 nuclei. This result agrees with the predictions from Unified Seyfert model proposed by Antonucci and Miller /1/. However, among the observed Seyfert 2 galaxies, there are a few galaxies with no evidence of an obscuration, contrary to the general predictions of the unified model. We note that type 2 AGN will contribute to the Cosmic Diffuse X-ray Background, if the unified Seyfert model can be extended to the far distant AGN such as quasars.     

Future of Space Astronomy: A global Road Map for the next decades

The use of space techniques continues to play a key role in the advance of astrophysics by providing access to the entire electromagnetic spectrum from radio to high energy γ rays. The increasing size, complexity and cost of large space observatories places a growing emphasis on international collaboration. Furthermore, combining existing and future datasets from space and “ground based” observatories is an emerging mode of powerful and relatively inexpensive research to address problems that can only be tackled by the application of large multi-wavelength observations. While the present set of astronomical facilities is impressive and covers the entire electromagnetic spectrum, with complementary space and “ground based” telescopes, the situation in the next 10–20 years is of critical concern. The James Webb Space Telescope (JWST), to be launched not earlier than 2018, is the only approved future major space astronomy mission. Other major highly recommended space astronomy missions, such as the Wide-field Infrared Survey Telescope (WFIRST), the International X-ray Observatory (IXO), Large Interferometer Space Antenna (LISA) and the Space Infrared Telescope for Cosmology and Astrophysics (SPICA), have yet to be approved for development.