Repair of DNA double-strand breaks and cell killing by charged particles.

It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS.     

Acquisition Time of Second-Order Aided PLL

The analysis of a second-order tracking loop operating in the frequency-search mode is carried out by the quasi-stationary approach. An arbitrary phase detector characteristic is assumed and perfect or imperfect integrating filters are considered. The theory leads to a closed-form expression of the acquisition time versus the relevant system parameters, the initial detuning, and the search rate. The limitations of this analysis concern the absence of noise and the hypothesis of large initial detuning.     

Plasma observations in the auroral and polar cap region

The last decade has seen a period of rapid growth in our understanding of the processes which occur in the auroral regions. Much of our understanding is based on the copious new observations which have been made available in the auroral community. The present work is a short overview of the plasma conditions which obtain throughout much of the auroral region. It covers the diffuse and discrete auroral electron precipitation in the morning and evening oval, cusp, and polar cap. The ionospheric ion outflow throughout the high latitude regime is also described and related to the electron observations.     

Multibaseline ATI-SAR for robust ocean surface velocity estimation

An open problem of along-track interferometry (ATI) for synthetic aperture radar (SAR) sensing of ocean surface currents is the need of ancillary wind information for inversion of Doppler centroid measurements, that have to be compensated for the propagation velocity of advancing and/or receding Bragg scatterers. We propose three classes of estimators which exploit multibaseline (MB) ATI acquisition and Doppler resolution for robust data inversion under different degrees of a priori information about the wind direction and the value of the characteristic Bragg frequency. Performance analysis and comparison with conventional ATI show that the proposed MB estimators can produce accurate velocity estimates in the absence of detailed ancillary data.     

The MELISSA pilot plant facility as as integration test-bed for advanced life support systems.

The different advances in the Micro Ecological Life Support System Alternative project (MELISSA), fostered and coordinated by the European Space Agency, as well as in other associated technologies, are integrated and demonstrated in the MELISSA Pilot Plant laboratory. During the first period of operation, the definition of the different compartments at an individual basis has been achieved, and the complete facility is being re-designed to face a new period of integration of all these compartments. The final objective is to demonstrate the potentiality of biological systems such as MELISSA as life support systems. The facility will also serve as a test bed to study the robustness and stability of the continuous operation of a complex biological system. This includes testing of the associated instrumentation and control for a safe operation, characterization of the chemical and microbial safety of the system, as well as tracking the genetic stability of the microbial strains used. The new period is envisaged as a contribution to the further development of more complete biological life support systems for long-term manned missions, that should be better defined from the knowledge to be gained from this integration phase. This contribution summarizes the current status of the Pilot Plant and the planned steps for the new period.     

Transient Nonstationary Behavior of a Delay Line Discriminator

The development of numerical methods for studying the transient nonstationary behavior of a delay line discriminator is presented. Expressions are developed for the mean and the variance of the output noise process. For the cases where the output is stationary, power density spectra are found.     

60 GHz FM-CWR Using NRD guide for distance estimation

An FM-CW radar front-end was fabricated in an integrated manner at 60 GHz by using the NRD guide. The main emphasis was placed on compactness in size and high-precise operation in performance. The fabricated radar consists of an FM Gunn oscillator, a balanced mixer, and a planar antenna fed by a leaky NRD guide with a mechanically beam-scanning performance. All circuit components and the antenna were contained in a compact housing of 170 x 140 mm in area and 25 mm in thickness, and thus, a thin type of millimeter-wave radar front-end was successfully developed. Moreover, an error of distance estimation was measured to be less than a distance of 0.7 m.     

Current Issues and Future Trends: DVB-RCS Satellite Systems

The telecommunications market is reaching new types of customers who require their applications anywhere and anyway. Therefore, the DVB-RCS standard, which had great success in the fixed version is changing in this direction. The main objective of this work is to give an overview of architectures and technologies that can be used for implementation of a first-generation of advanced mobile satellite systems for the provision of broadband multimedia services.     

Initial results from the ISEE-1 and -2 plasma wave investigation

In this paper we present an initial survey of results from the plasma wave experiments on the ISEE-1 and -2 spacecraft which are in nearly identical orbits passing through the Earth's magnetosphere at radial distances out to about 22.5R _e . Essentially every crossing of the Earth's bow shock can be associated with an intense burst of electrostatic and whistler-mode turbulence at the shock, with substantial wave intensities in both the upstream and downstream regions. Usually the electric and magnetic field spectrum at the shock are quite similar for both spacecraft, although small differences in the detailed structure are sometimes apparent upstream and downstream of the shock, probably due to changes in the motion of the shock or propagation effects. Upstream of the shock emissions are often observed at both the fundamental, f _- ^p , and second harmonic, 2f _p ^- , of the electron plasma frequency. In the magnetosphere high resolution spectrograms of the electric field show an extremely complex distribution of plasma and radio emissions, with numerous resonance and cutoff effects. Electron density profiles can be obtained from emissions near the local electron plasma frequency. Comparisons of high resolution spectrograms of whistler-mode emissions such as chorus detected by the two spacecraft usually show a good overall similarity but marked differences in detailed structure on time scales less than one minute. Other types of locally generated waves, such as the (n+1/2)f _- ^g electron cyclotron waves, show a better correspondence between the two spacecraft. High resolution spectrograms of kilometric radio emissions are also presented which show an extremely complex frequency-time structure with many closely spaced narrow-band emissions.