Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

概率具有普遍意义

在事物必然的性质、方向和由此决定的活动范围之外,它发生、发展的每一具体变化都是偶然的.为了抓住偶然,就要求助于概率,概率已经成为我们的重要工具.     

砂轮不等分间隙槽的切割方法

在生产实践中总结出一种提高难加工材料磨削效率的方法——将砂轮修成不等分的间隙槽。介绍了将砂轮修成不等分间隙槽的制作过程,以及在生产应用中的使用效果。     

钣金制件表面的相贯线求作方法

本文提出钣金制件表面相贯线求作的新方法。     

激光外差干涉仪光电信号处理方法及特点

叙述和分析了外差激光干涉光电信号处理主其特点，指出了它们各自的应用范围，同时介绍了一处新型的光电信号处理方法，它不仅使外差干涉仪用于动态测量，而且可以同时实现高分辩率测量 。     

图样的知识目标分类与例证性分析

根据教育目标分类学的观点分解课程教学目标，再分别对分解的目标进行例证性分析，能更客观地验证教育目标的实效性和教育过程的可行性。本文通过对图样的知识目标分类与例证性分析，为工程图学教育目标检测做一尝试。     

On adaptive spatial-temporal processing for airborne surveillanceradar systems

Implementing the optimum spatial-temporal (angle-Doppler) processor involves two crucial issues: the selection of processing configurations, and the development of adaptive algorithms which can efficiently approach the performance potential of the selected configuration. Among the three available configurations, the joint-domain, the cascade space-time, and the cascade time-space, this work shows that, in contrast to a popular belief, the detection performance potentials of both cascade configurations can fall far below that of the joint-domain optimum. In addition, this work presents a new adaptive algorithm, called the Joint-Domain Localized Generalized Likelihood Ratio detection (JDL-GLR), which is data efficient i.e., with fast convergence to the joint-domain optimum, as well as computationally efficient, together with such desirable features as the embedded constant false-alarm rate (CFAR) and robustness in non-Gaussian interference     

拓宽周转齿轮系的应用

本文为拓宽创新设计机构的思路,扼要地介绍了一种利用空间周转轮系,实观机械手臂的公转与自转动作要求的机构运动分析、设计方案及结构参考图。     

改进的次时间最优控制

本文在[1][2]基础上进一步探讨了次时间最优控制的改进问题,深入地阐明了次时间最优控制的某些特性后,提出了一个新的改进的设计方法。按照这种方法设计控制系统,不但实用而且可以大幅度提高次时间最优控制的最优性。并用实例比较了各种方法,证明了本文提出的方法的优越性。本文提出的方法应用于工程设计,对于提高系统的最优性是非常有效的。     

数控系统内置式PLC的FPGA实现方法

提出了一种用FPGA实现数控系统内置式PLC的方法.通过在FPGA内部实现PLC逻辑,并提供能够编译PLC指令的编译器,实现了数控系统对通用PLC编程语言的支持.所述方法在基于ARM FPGA的数控系统上得到了实现.