Loading effects on rat craniomandibular morphology: a system for gravity studies

Gravity effects on muscle and bone are a major impediment to long-term space travel. We introduce a model for studying these effects, the craniomandibular system. Some advantages of this system include: (1) craniomandibular morphology is determined by epigenetic factors including gravity, (2) relatively light forces can significantly alter its morphology, and (3) soft diet and tooth loss produce effects that are similar to those produced in lower limbs by weightlessness. In the study, implants made either of gold (experimental group) or lightweight acrylic (controls) were attached to adult rats' mandibles. After 13 weeks, the animals' skulls and mandibles were dissected. Pair-wise comparisons indicated that the experimental animals showed significantly shortened and narrowed cranial bases, and significant changes in the posterior zygomatic arch region. These results indicate that simulated macrogravity influences bone remodeling in the adult craniomandibular system.     

Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments)

Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.     

一种少烟固体火箭发动机的结构使用寿命估计

少烟幼畜(Maverich)固体火箭发动机的结构使用寿命估计是以解剖发动机的推进剂性能数据为基础进行的。为了在两年的时间里模拟五年的使用寿命,这些发动机经历了实验室加速化学和力学老化。用经验老化模型来推测发动机推进剂的性能和药柱横截面上的性能梯度,建立了有限元计算机模型来计算这些性能梯度,并确定发动机安全裕度与时间的函数关系。根据分析,预计这种发动机的使用寿命在10年之上。     

星30/CE和星37FM——改进性能的顶级固体火箭发动机

本文介绍了星30C、30E和37FM三种火箭发动机的设计结构,给出了各种分析结果,并报导了鉴定试验的累积数据。     

大学生入职培训的措施探讨

文章简要分析了大学生入职培训的主要目的,在此基础上剖析了企业在开展大学生入职培训工作中存在的不足,并结合初进职场大学生的思想行为特点,从入职培训的延续性、培训内容、培训方法等几方面提出了改进建议。     

航天型号产品供方管理模式初探

文章对航天型号产品供方管理存在问题进行了分析,提出了航天型号产品供方管理的目标和管理模式的设想,从确定供方选择原则、建立灵活适用的供方绩效评价指标体系、建立供方数据采集和分析模型、识别和优化供方、规范航天型号产品供方评价方法和程序等几个方面进行了浅入分析。     

入世对中国再保险业的影响及对策--"9.11"事件引起的思考

论文通过分析中国再保险业的现状以及入世后中国再保险业面临的机遇与挑战，探索中国再保险业应对入世的发展对策。     

PC机上视景同步仿真的实现

随着导弹模拟训练系统在用户训练中的广泛应用，为了能够使操作人员在模拟训练的过程中有逼真效果，必须较好地实现实际装备操作过程中的视景仿真。结合自动检测、多媒体技术、视景音响模拟技术，运用Delphi6成功完成了某导弹模拟系统的研制，该模拟训练系统可逼真地再现实际装备操作训练视景的全过程。     

改善推进剂老化和低温物理性质的键合剂系统

新的混合键合剂系统用于端羟基聚丁二烯推进剂配方时,推进剂的高温老化特性和低温物理性质都有很大改善。混合键合剂系统由 MT_4[2.0克分子三-1-(2-甲基氮丙啶)膦化氧、0.7克分子已二酸和0.3克分子酒石酸的反应产物]、HX752[双-间苯二酰-1-(2-甲基)氨丙啶]和 BIDE(丁基亚胺二乙醇)组成,其重量百分含量分别占推进剂组成的0.10～0.20%、0.10～0.20%和0.02～0.05%。