Evaluation of upper body muscle activity during cardiopulmonary resuscitation performance in simulated microgravity

Performance of efficient single-person cardiopulmonary resuscitation (CPR) is vital to maintain cardiac and cerebral perfusion during the 2–4 min it takes for deployment of advanced life support during a space mission. The aim of the present study was to investigate potential differences in upper body muscle activity during CPR performance at terrestrial gravity (+1Gz) and in simulated microgravity (μG). Muscle activity of the triceps brachii, erector spinae, rectus abdominis and pectoralis major was measured via superficial electromyography in 20 healthy male volunteers. Four sets of 30 external chest compressions (ECCs) were performed on a mannequin. Microgravity was simulated using a body suspension device and harness; the Evetts–Russomano (ER) method was adopted for CPR performance in simulated microgravity. Heart rate and perceived exertion via Borg scores were also measured. While a significantly lower depth of ECCs was observed in simulated microgravity, compared with +1Gz, it was still within the target range of 40–50 mm. There was a 7.7% decrease of the mean (±SEM) ECC depth from 48 ± 0.3 mm at +1Gz, to 44.3 ± 0.5 mm during microgravity simulation (p < 0.001). No significant difference in number or rate of compressions was found between the two conditions. Heart rate displayed a significantly larger increase during CPR in simulated microgravity than at +1Gz, the former presenting a mean (±SEM) of 23.6 ± 2.91 bpm and the latter, 76.6 ± 3.8 bpm (p < 0.001). Borg scores were 70% higher post-microgravity compressions (17 ± 1) than post +1Gz compressions (10 ± 1) (p < 0.001). Intermuscular comparisons showed the triceps brachii to have significantly lower muscle activity than each of the other three tested muscles, in both +1Gz and microgravity. As shown by greater Borg scores and heart rate increases, CPR performance in simulated microgravity is more fatiguing than at +1Gz. Nevertheless, no significant difference in muscle activity between conditions was found, a result that is favourable for astronauts, given the inevitable muscular and cardiovascular deconditioning that occurs during space travel.     

Time-dependent thermal X-ray afterglows from GRBS

Time-dependent thermal X-ray spectra are calculated from physically plausible conditions around GRB. It is shown that account for time-dependent ionization processes strongly affects the observed spectra of hot rarefied plasma. These calculations may provide an alternative explanation to the observed X-ray lines of early GRBs afterglows (such as GRB 011211). Our technique will allow one to obtain independent constraints on the GRB collimation angle and on the clumpiness of circumstellar matter.     

Measuring the matter distribution within z = 0.2 cluster lenses with XMM-Newton

We present an analysis of seven clusters observed by XMM-Newton as part of our survey of 17 most X-ray luminous clusters of galaxies at z  0.2 selected for a comprehensive and unbiased study of the mass distribution in massive clusters. Using the public software FTOOLS and XMMSAS we have set up an automated pipeline to reduce the EPIC MOS and pn spectro-imaging data, optimized for extended sources analysis. We also developped a code to perform intensive spectral and imaging analysis particularly focussing on proper background estimate and removal. XMM-Newton deep spectro-imaging of these clusters allowed us to fit a standard β-model to their gas emission profiles as well as a standard MEKAL emission model to their extracted spectra, and test their inferred characteristics against already calibrated relations.     

Annual solar UV exposure and biological effective dose rates on the Martian surface.

The ultraviolet (UV) environment of Mars has been investigated to gain an understanding of the variation of exposure throughout a Martian year, and link this flux to biological effects and possible survival of organisms at the Martian surface. To gain an idea of how the solar UV radiation varies between different regions, including planned landing sites of two future Mars surface missions, we modelled the total solar UV surface flux throughout one Martian year for two different dust scenarios. To understand the degree of solar UV stress on micro-organisms and/or molecules essential for life on the surface of Mars, we also calculated the biologically effective dose (BED) for T7 and Uracil in relevant wavelength regions at the Martian surface as a function of season and latitude, and discuss the biological survival rates in the presence of Martian solar UV radiation. High T7/Uracil BED ratios indicate that even at high latitudes where the UV flux is significantly reduced, the radiation environment is still hostile for life due to the persisting UV-C component of the flux.     

Uncertainties in estimates of the risks of late effects from space radiation.

Methods used to project risks in low-Earth orbit are of questionable merit for exploration missions because of the limited radiobiology data and knowledge of galactic cosmic ray (GCR) heavy ions, which causes estimates of the risk of late effects to be highly uncertain. Risk projections involve a product of many biological and physical factors, each of which has a differential range of uncertainty due to lack of data and knowledge. Using the linear-additivity model for radiation risks, we use Monte-Carlo sampling from subjective uncertainty distributions in each factor to obtain an estimate of the overall uncertainty in risk projections. The resulting methodology is applied to several human space exploration mission scenarios including a deep space outpost and Mars missions of duration of 360, 660, and 1000 days. The major results are the quantification of the uncertainties in current risk estimates, the identification of factors that dominate risk projection uncertainties, and the development of a method to quantify candidate approaches to reduce uncertainties or mitigate risks. The large uncertainties in GCR risk projections lead to probability distributions of risk that mask any potential risk reduction using the "optimization" of shielding materials or configurations. In contrast, the design of shielding optimization approaches for solar particle events and trapped protons can be made at this time and promising technologies can be shown to have merit using our approach. The methods used also make it possible to express risk management objectives in terms of quantitative metrics, e.g., the number of days in space without exceeding a given risk level within well-defined confidence limits.     

Controllable passive detectors for study of the radiation environment in space and the atmosphere

We propose to study the radiation environment on board different flight vehicles: cosmos-type satellites, orbital stations, Space Shuttles and civil (sonic and supersonic) aircraft. These investigations will be carried out with single type of passive detector, namely, nuclear photoemulsions (NPE) with adjustable threshold of particle detection within broad range of linear energy transfer (LET) that is done by means of the technique of selective development of NPE exposed in space.

These investigations will allow one to determine:

• integral spectra of LET of charged particles of cosmic ray (CR) over a wide range from 2.0 to 5×10⁴ MeV/cm in biological tissue;

• differential energy spectra of fast neutrons (1–20 MeV);

• estimation of absorbed and equivalent doses from charged and neutral component CR;

• charge and energy spectra of low energy nuclei (E≤100 MeV) with Z≥2 having in view the extreme hazard radiation to biological objects and microelectronic schemes taken on board inside and outside of these different flight vehicles with exposures from several days to several months.

The investigation of radiation environment on board the airplanes depending on the flight parameters will be conducted using emulsions of different sensitivity without any controlling of threshold sensitivity (Akopova et al., 1996). The proposed detector can be used in the joint experiments on the new International Cosmic Station “Alpha”.     

Seasonal-to-interannual variability of chlorophyll-a bloom timing associated with physical forcing in the Gulf of Cádiz

Seasonal-to-interannual variability of the winter-spring bloom in the Gulf of Cádiz, eastern North Atlantic, has been investigated using chlorophyll-a remote sensing (CHL). These data have been obtained from the GlobColour project; the temporal coverage extends from September 1997 to December 2010. In this study we develop a generic quantitative approach for describing the temporal variability in the shape of the winter-spring bloom within a region. Variability in both the timing and magnitude of the bloom in the basin has been evaluated as a function of physical properties in the water column such as Mixed Layer Depth (MLD, GODAS model), sea surface temperature (SST, from AVHRR radiometers), photosynthetically-active radiation (PAR, from ocean color data) and euphotic depth (Z_eu, from ocean color data). The analysis indicated that the timing, size and duration of the phytoplankton bloom in this area are largely controlled by both meteorological and oceanographic conditions at different scales; this means that it is likely to vary widely from one year to another.     

Magnetospheric disturbances associated with the 13 December 2006 solar flare and their ionospheric effects over North-East Asia

We present an observational study of magnetospheric and ionospheric disturbances during the December 2006 intense magnetic storm associated with the 4В/Х3.4 class solar flare. To perform the study we utilize the ground data from North–East Asian ionospheric and magnetic observatories (60–72°N, 88–152°E) and in situ measurements from LANL, GOES, Geotail and ACE satellites. The comparative analysis of ionospheric, magnetospheric and heliospheric disturbances shows that the interaction of the magnetosphere with heavily compressed solar wind and interplanetary magnetic field caused the initial phase of the magnetic storm. It was accompanied by the intense sporadic E and F2 layers and the total black-out in the nocturnal subauroral ionosphere. During the storm main phase, LANL-97A, LANL 1994_084, LANL 1989-046 and GOES_11 satellites registered a compression of the dayside magnetosphere up to their orbits. In the morning–noon sector the compression was accompanied by an absence of reflections from ionosphere over subauroral ionospheric station Zhigansk (66.8°N, 123.3°E), and a drastic decrease in the F2 layer critical frequency (foF2) up to 54% of the quite one over subauroral Yakutsk station (62°N, 129.7°E). At the end of the main phase, these stations registered a sharp foF2 increase in the afternoon sector. At Yakutsk the peak foF2 was 1.9 time higher than the undisturbed one. The mentioned ionospheric disturbances occurred simultaneously with changes in the temperature, density and temperature anisotropy of particles at geosynchronous orbit, registered by the LANL-97A satellite nearby the meridian of ionospheric and magnetic measurements. The whole complex of disturbances may be caused by radial displacement of the main magnetospheric domains (magnetopause, cusp/cleft, plasma sheet) with respect to the observation points, caused by changes in the solar wind dynamic pressure, the field of magnetospheric convection, and rotation of the Earth.     

GNSS-R concept extended by a fine orbit tuning

Small changes in semimajor axis of the orbits selected for the GNSS-R [R as Reflectometry] satellites, so-called fine orbit tuning, known from the ESA’s Gravity and steady-state Ocean Circulation Explorer mission, can dramatically increase the number of nadir and off-nadir reflecting points and, in turn, can enhance the capability of the concept of bistatic altimetry (GNSS Reflectometry) without additional costs. The application of our suggestion is feasible for a satellite which will be equipped by thrusters for the orbit keeping. During the mission lifetime several orbit tunings are feasible, just to transfer from one to another orbit. Then we can study short-periodic or longer-periodic features, according to scientific goals defined for the mission. The shortest cycles (few days), corresponding to the required revisit time (defined by ESA), may be subcycles of much longer cycles (repeat periods).