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101.
  总被引:1,自引:0,他引:1  
The biological effects of high LET charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/micrometer to 975 KeV/micrometer with particle energy (on the cells) between 94-603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/micrometer. The inactivation cross-section (alpha i) and the action cross-section for mutant induction (alpha m) ranged from 2.2 to 92.0 micrometer2 and 0.09 to 5.56 x 10(-3) micrometer2, respectively. The maximum values were obtained by 56Fe with an LET of 200 keV/micrometer. The mutagenicity (alpha m/alpha i) ranged from 2.05 to 7.99 x 10(-5) with the maximum value at 150 keV/micrometer. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus.  相似文献   
102.
    
Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.  相似文献   
103.
    
Lake water height is a key variable in water cycle and climate change studies, which is achievable using satellite altimetry constellation. A method based on data processing of altimetry from several satellites has been developed to interpolate mean lake surface (MLS) over a set of 22 big lakes distributed on the Earth. It has been applied on nadir radar altimeters in Low Resolution Mode (LRM: Jason-3, Saral/AltiKa, CryoSat-2) in Synthetic Aperture Radar (SAR) mode (Sentinel-3A), and in SAR interferometric (SARin) mode (CryoSat-2), and on laser altimetry (ICESat). Validation of the method has been performed using a set of kinematic GPS height profiles from 18 field campaigns over the lake Issykkul, by comparison of altimetry’s height at crossover points for the other lakes and using the laser altimetry on ICESat-2 mission. The precision reached ranges from 3 to 7 cm RMS (Root Mean Square) depending on the lakes. Currently, lake water level inferred from satellite altimetry is provided with respect to an ellipsoid. Ellipsoidal heights are converted into orthométric heights using geoid models interpolated along the satellite tracks. These global geoid models were inferred from geodetic satellite missions coupled with absolute and regional anomaly gravity data sets spread over the Earth. However, the spatial resolution of the current geoid models does not allow capturing short wavelength undulations that may reach decimeters in mountaineering regions or for rift lakes (Baikal, Issykkul, Malawi, Tanganika). We interpolate in this work the geoid height anomalies with three recent geoid models, the EGM2008, XGM2016 and EIGEN-6C4d, and compare them with the Mean Surface of 22 lakes calculated using satellite altimetry. Assuming that MLS mimics the local undulations of the geoid, our study shows that over a large set of lakes (in East Africa, Andean mountain and Central Asia), short wavelength undulations of the geoid in poorly sampled areas can be derived using satellite altimetry. The models used in this study present very similar geographical patterns when compared to MLS. The precision of the models largely depends on the location of the lakes and is about 18 cm, in average over the Earth. MLS can serve as a validation dataset for any future geoid model. It will also be useful for validation of the future mission SWOT (Surface Water and Ocean Topography) which will measure and map water heights over the lakes with a high horizontal resolution of 250 by 250 m.  相似文献   
104.
    
The control of water content and water movement in granular substrate-based plant root systems in microgravity is a complex problem. Improper water and oxygen delivery to plant roots has delayed studies of the effects of microgravity on plant development and the use of plants in physical and mental life support systems. Our international effort (USA, Russia and Bulgaria) has upgraded the plant growth facilities on the Mir Orbital Station (OS) and used them to study the full life cycle of plants. The Bulgarian-Russian-developed Svet Space Greenhouse (SG) system was upgraded on the Mir OS in 1996. The US developed Gas Exchange Measurement System (GEMS) greatly extends the range of environmental parameters monitored. The Svet-GEMS complex was used to grow a fully developed wheat crop during 1996. The growth rate and development of these plants compared well with earth grown plants indicating that the root zone water and oxygen stresses that have limited plant development in previous long-duration experiments have been overcome. However, management of the root environment during this experiment involved several significant changes in control settings as the relationship between the water delivery system, water status sensors, and the substrate changed during the growth cycles.  相似文献   
105.
    
The planned exploration of Mars will pose new and unique telecommunications and navigation challenges. The full range of orbital, atmospheric, and surface exploration will drive requirements on data return, energy-efficient communications, connectivity, and positioning. In this paper we will summarize the needs of the currently planned Mars exploration mission set, outline design trades and options for meeting these needs, and quantify the specific telecommunications and navigation capabilities of an evolving infrastructure.  相似文献   
106.
While Ovonic NiMH batteries are already in high volume commercial production for portable applications, advances in materials technology have enabled performance improvements in specific energy (100 Wh/kg), specific power (600-1000 W/kg), high temperature operation, charge retention, and voltage stability. Concurrent with technology advances, Ovonic NiMH batteries have established performance and commercial milestones in electric vehicles, hybrid electric vehicles, as well as scooter, motorcycle and bicycle applications. As important as these advances, significant manufacturing cost reductions have also occurred which allow continued growth of NiMH technology. In this paper, advances in performance, applications and cost reduction are discussed with particular emphasis on the improved proprietary metal hydride and nickel hydroxide materials that make such advances possible  相似文献   
107.
    
Star identification can be accomplished by several different available algorithms that identify the stars observed by a star tracker. However, efficiency and reliability remain key issues and the availability of new active pixel cameras requires new approaches. Two novel algorithms for recursive mode star identification are presented here. The first approach is derived by the spherical polygon search (SP-search) algorithm, it was used to access all the cataloged stars observed by the sensor field-of-view (FOV) and recursively add/remove candidate cataloged stars according to the predicted image motion induced by camera attitude dynamics. Star identification is then accomplished by a star pattern matching technique which identifies the observed stars in the reference catalog. The second method uses star neighborhood information and a catalog neighborhood pointer matrix to access the star catalog. In the recursive star identification process, and under the assumption of \"slow\" attitude dynamics, only the stars in the neighborhood of previously identified stars are considered for star identification in the succeeding frames. Numerical tests are performed to validate the absolute and relative efficiency of the proposed methods.  相似文献   
108.
Observations of the Galactic center region with the H.E.S.S. telescopes have established the existence of a steady, extended source of gamma-ray emission coinciding with the position of the super massive black hole Sgr A*. This is a remarkable finding given the expected presence of dense self-annihilating Dark Matter in the Galactic center region. The self-annihilation process is giving rise to gamma-ray production through hadronization including the production of neutral pions which decay into gamma-rays but also through (loop-suppressed) annihilation into final states of almost mono-energetic photons. We study the observed gamma-ray signal (spectrum and shape) from the Galactic center in the context of Dark Matter annihilation and indicate the prospects for further indirect Dark Matter searches with H.E.S.S.  相似文献   
109.
The Meteorology Department of India has been measuring vertical column density of NO2 at Maitri (70.7°S, 11.7°E), Antarctica since July 1999 using a Mark IV, Brewer Ozone Spectrophotometer. Maitri is situated at the south of the Antarctic circle. An analysis of 6 years of data shows that NO2 column has seasonal variation with a maximum value during summer. It is also found that during the period when sun does not set, the NO2 column exhibits a diurnal variation, with a peak around noon and lower values in the morning and afternoon hours. Using a simple steady-state chemical reaction scheme, an attempt has been made to explain these features.  相似文献   
110.
    
The paper comprises an assessment of the design and the economics of so-called “low-cost” simple modular launch vehicles. It is shown that the performance is very marginal and that the cost per launch cannot compete with technically more advanced fully reusable vehicles. Especially a private-funded development cannot be amortized economically in case of an expendable launch vehicle.  相似文献   
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