Neoplastic transformation of mouse C3H 10T1/2 and Syrian hamster embryo cells by heavy ions.

C3H 10T1/2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16,000 keV/micrometers. The transformation frequency per unit absorbed dose decreased with increasing ionization density; at the highest values of LET we found a decrease even of the transformation efficiency per unit fluence. Uranium ions at energies of 5, 9, and 16.3 MeV/u did not induce any transformation. In additional studies primary Syrian hamster embryo cells (SHE) were exposed to heavy ions in order to characterize cytological and molecular changes which may be correlated with neoplastic transformation. Growth behaviour, chromosomal status, tumorigenicity in nude mice, and expression of oncogenes of transformed cell lines were examined     

Integrated CIS VLF/Omega receiver design

The design of an integrated Russian-VLF/Omega receiver implemented on a TMS320C30-microprocessor-based SPECTRUM plug-in board installed in a PC-compatible portable computer is presented. The system also requires an external antenna, pre-amp, and frequency reference. The SPECTRUM board digitizes the RF signal to 16 b and then digitally mixes with the sines and cosines of the three Russian frequencies plus 10.2, 11-1/3, and 13.6 kHz. The mixer outputs are low-pass filtered, and the comb filters are implemented for the respective epochs. The computer accesses and processes the comb filter outputs, calculating and logging signal phase and amplitude. The design allows for easy future expansion to include unique and VLF communication frequencies     

Chemical evolution of RNA under hydrothermal conditions and the role of thermal copolymers of amino acids for the prebiotic degradation and formation of RNA.

The roles of thermal copolymers of amino acids (TCAA) were studied for the prebiotic degradation of RNA. A weak catalytic ability of TCAA consisted of Glu, L-Ala, L-Val, L-Glu, L-Asp, and optionally L-His was detected for the cleavage of the ribose phosphodiester bond of a tetranucleotide (5'-dCrCdGdG) in aqueous solution at 80 degees C. The rate constants of the disappearance of 5'-dCrCdGdG were determined in aqueous solutions using different pH buffer and TCAA. The degradation rates were enhanced 1.3-3.0 times in the presence of TCAA at pH 7.5 and 8.0 at 80 degrees C, while the hydrolysis of oligoguanylate (oligo(G)) was accelerated about 1.6 times at pH 8.0. A weak inhibitory activity for the cleavage of oligo(G) was detected in the presence of 0.055 M TCAA-Std. On the other hand, our recent study on the influences of TCAA for the template-directed reaction of oligo(G) on a polycytidylic acid template showed that TCAA has an acceleration activity for the degradation of the activated nucleotide monomer and an acceleration activity for the formation of G5' ppG capped oligo(G). This series of studies suggest that efficient and selective catalytic or inhibitory activities for either the degradation or formation of RNA under hydrothermal conditions could have hardly emerged from the simple thermal condensation products of amino acids. A scenario is going to be deduced on the chemical evolution of enzymatic activities and RNA molecules concerning hydrothermal earth conditions.     

Statistical description of low-latitude plasma blobs as observed by DMSP F15 and KOMPSAT-1

The global distribution of low-latitude plasma blobs was investigated by in-situ plasma density measurements from the Korea Multi-Purpose Satellite-1 (KOMPSAT-1) and Defense Meteorological Satellite Program (DMSP) F15. In the observations, blobs occurred in the longitude sector where the activity of the equatorial plasma bubble (EPB) was appreciable, and additional blobs were found at the lower (KOMPSAT-1) altitude as in the EPBs. However, several notable differences exist between the distributions of EPBs and blobs. First, KOMPSAT-1 found few blobs around 0°E in March and June, as did DMSP F15 from 30°W to 120°E for every season. Second, the overall occurrences in December and March at the DMSP F15 (840 km) altitude were somewhat lower than expected from those of the EBPs. Third, at the DMSP F15 altitude, the occurrence probability of plasma blobs was less controlled by yearly variations in the solar activity. These results imply that topside ionospheric conditions as well as the existence of EPBs control further development of blobs. Additionally, it was found that the blob latitudes became higher as the yearly solar activity increased. Moreover, most of the blobs were encountered in the winter hemisphere, possibly due to the low ambient density.     

Simultaneous investigation of magnetospheric plasma and spacecraft charging

The results of magnetospheric plasma fluxes measurement in geosynchronous orbit are presented. The measurements were done onboard the geosynchronous Russian “Electro” spacecraft (SC) in 1995–1997 years. The diurnal variations of the plasma density and temperature were observed at various levels of geomagnetic activity.     

Energetic particle measurements onboard Spectr-R with MEP-2

The energetic particle experiment MEP-2 onboard the Spectr-R high apogee satellite is briefly described. The instrument measures fluxes and spectra of electrons (30 keV–350 keV) and ions (30 keV–3.2MeV), using two pairs of silicon detectors. The example of first observations upstream from the bow shock illustrates its successful operation in space. Unique observations of ～30 s strong fluctuations of energetic ions with energies up to two hundred keV are discussed.     

Spectroscopic observations of coronal waves and coronal mass ejections

It is common to use imaging instruments such as EUV and X-ray imagers and coronagraphs to study large-scale phenomena such as coronal mass ejections and coronal waves. Although high resolution spectroscopy is generally limited to a small field of view, its importance in understanding global phenomena should not be under-estimated. I will review current spectroscopic observations of large-scale dynamic phenomena such as global coronal waves and coronal mass ejections. The aim is to determine plasma parameters such as flows, temperatures and densities to obtain a physical understanding of these phenomena.     

Application of laser diode beacons for determination of coordinates of space and ground objects

We consider the principles of constructing measurement schemes with optical autonomous laser diode beacons for space and ground objects. The structure, functional scheme, and cyclogram of operation of such beacons are described. Possible scenarios of application of the beacons for providing high-precision localization of space and ground devices are analyzed.     

United States space policy and international partnership

Has the current US space policy improved the USA's overall strategic position? Does it affect favorably international partnerships? These questions are examined in terms of security, political economy, and influence. In today's context, where there are more space players, more options, more potential for unintended consequences, and higher stakes, unilateral action is more limited in its effectiveness than in earlier times. Surveying current US space policy, it is not clear that data-driven, analytically based decisions are being made to affect positively national independence, innovation, market creation, and international perceptions of the USA as a trustworthy partner. More promising are the steps taken to bolster a predictable space operational environment and economic competitiveness. Ultimately, in order to achieve American excellence and leadership, a ‘closed loop’ on the policy system is needed, to gauge regularly and systematically whether the US is achieving the desired national outcomes.