Detection of microlesions induced by heavy ions using liposomes filled with fluorescent dye.

In cells irradiation by heavy ions has been hypothesized to produce microlesions, regions of local damage. In cell membranes this damage is thought to manifest itself in the form of holes. The primary evidence for microlesions comes from morphological studies of cell membranes, but this evidence is still controversial, especially since holes also have been observed in membranes of normal, nonirradiated, cells. However, it is possible that damage not associated with histologically discernable disruptions may still occur. In order to resolve this issue, we developed a system for detecting microlesions based on liposomes filled with fluorescent dye. We hypothesized that if microlesions form in these liposomes as the result of irradiation, then the entrapped dye will leak out into the surrounding medium in a measurable way. Polypropylene vials containing suspensions of vesicles composed of either dipalmitoyl phosphatidylcholine, or a combination of egg phosphatidylcholine and cholesterol were irradiated at the Brookhaven National Laboratory using 56Fe ions at 1 GeV/amu. In several cases we obtained a significant loss of the entrapped dye above the background level. Our results suggest that holes may form in liposomes as the result of heavy ion irradiation, and that these holes are large enough to allow leakage of cell internal contents that are at least as large as a 1 nm diameter calcein molecule.     

称重传感器的一种新的滞后补偿方法(英文)

通过对电阻应变式称重传感器在各种加载卸载情况下的滞后特性的分析 ,建立了其相应的数学模型 ,并初步探讨了一种可以通过程序在仪表中对传感器的重要指标—滞后进行补偿从而提高整个传感器的精度的方法。最后 ,对以上方法进行了验证性试验 ,证明了补偿方法的可行性。     

The Electron Beam Instrument (F6) on Freja

The Electron Beam Instrument (F6) onFreja is the first attempt to apply the electron drift technique in a region of large ambient magnetic fields. The paper describes the operational principles, the technical realization, and the difficulties encountered in the derivation of the electric fields.     

EUROPEAN NETWORK FOR THE NUMERICAL SIMULATION OF SPACE PLASMAS

The Cluster mission of the European Space Agency (ESA) will allow, for the first time three-dimensional measurements in key regions of the Earth's magnetosphere to be carried out. The European Numerical Simulation Network (ENSN) aims at providing a theoretical support to the mission. We describe the achievements of the ENSN during its first period of activity 1991–1994, during which the network was funded by the European Union. In particular, the ENSN has set up (i) thematic Working Groups on the prime scientific goals of the mission, (ii) a code development Working Group to develop numerical simulation codes specifically adapted to studying magnetospheric boundaries and the corresponding scale mixing, and (iii) software models of Cluster instruments to test in a numerical simulation what the set of four instruments will measure.     

Large lithium ion batteries for aerospace and aircraft applications

Eagle-Picher Energy Products (EPEP) has been manufacturing and testing large lithium ion cells (up to 100-Ah) for several years. Recently, work has focused on the testing of different chemistries at variable temperatures and designing and fabricating 100-Ah cylindrical cells. For the aircraft application the largest concern is irreversible capacity loss at elevated temperatures (70°C). In contrast, for the aerospace application shelf-life and cycle life are critical. EPEP has found that the major contributor to the loss in low temperature performance due to high temperature testing, was the positive electrode. EPEP discuss recent results of variable temperature cycling and 100-Ah cell performance     

Senrad: an advanced wideband air-surveillance radar

The generic characteristics and performance of an experimental long-range air-surveillance radar, known at the Naval Research Laboratory as Senrad, is described. Its distinguishing feature is that it can operate with simultaneous transmissions over a very wide bandwidth-from 850 to 1400 MHz. The technology and type of experimental radar equipment employed are discussed and examples are given of its performance capabilities obtained by means of very wideband operation. The unusually wide bandwidth of this radar allows 1) improved detection and tracking performance because of the absence of the nulls that are common in the antenna elevation radiation-pattern of a single-frequency radar; 2) moving target indication (MTI) without loss of targets due to blind speeds and without the need for multiple PRFs (pulse repetition frequencies); 3) accurate height finding with a fan-beam radar by taking advantage of the multipath time difference as a function of target height; 4) a form of limited target recognition based on high range-resolution; and 5) a reduction of the effectiveness of electronic countermeasures that can seriously degrade more narrowband radars     

Observer-type Kalman innovation filter for uncertain linear systems

An observer-type of Kalman innovation filtering algorithm to find a practically implementable "best" Kalman filter, and such an algorithm based on the evolutionary programming (EP) optima-search technique, are proposed, for linear discrete-time systems with time-invariant unknown-but-hounded plant and noise uncertainties. The worst-case parameter set from the stochastic uncertain system represented by the interval form with respect to the implemented "best" filter is also found in this work for demonstrating the effectiveness of the proposed filtering scheme. The new EP-based algorithm utilizes the global optima-searching capability of EP to find the optimal Kalman filter and state estimates at every iteration, which include both the best possible worst case Interval and the optimal nominal trajectory of the Kalman filtering estimates of the system state vectors. Simulation results are included to show that the new algorithm yields more accurate estimates and is less conservative as compared with other related robust filtering schemes     

Improved tracking of maneuvering targets: The use of turn-ratedistributions for acceleration modeling

Tactically maneuvering targets are difficult to track since acceleration cannot be observed directly and the accelerations are induced by human control or an autonomous guidance system therefore they are not subject to deterministic models. A common tracking system is the two-state Kalman filter with a Singer maneuver model where the second-order statistics of acceleration is the same as a first-order Markov process. The Singer model assumes a uniform probability distribution on the targets acceleration which is independent of the x and y direction. In practice, it is expected that targets have constant forward speed and an acceleration vector normal to the velocity vector, a condition not present in the Singer model. The work of Singer is extended by presenting a maneuver model which assumes constant forward speed and a probability distribution on the targets turn-rate. Details of the model are presented along with sample simulation results     

A SAR processor based on two-dimensional FFT codes

A synthetic aperture radar (SAR) processor approach based on two-dimensional fast Fourier transform (FFT) codes coupled with an asymptotic evaluation of the unit response function is presented. For the latter, no approximation is made to the distance function, so that the full range of geometric aberrations is analytically considered, enabling an effective reference filter to be designed. The two-dimensional FFTs were designed as to run on computers of very limited memory: the required FFT is computed by means of FFTs of lower order. Two FFT codes were considered: one is faster and allows full or reduced (quick look or multilook) resolution performance to be obtained easily; the second is slower but allows the use of a space-varying filter and/or investigations on limited portions (zoom) of the image. Both codes are suited to parallel processing, e.g. by a transputer net. A full discussion on computer memory and time requirements is presented as well as first examples of image processing results     

Century scale solar variability imprinted in the 44Ti activity in meteorites.

The measurements of gamma-activity of the 44Ti (T1/2 = 66.6 years) produced by spallation reaction of galactic cosmic rays (GCR) in Alfianello, Olivenza, Rio Negro, Dhajala and Torino meteorites, which fell in the time interval 1883 AD (Alfianello)-1988 AD (Torino), show a century scale modulation, connected to long-term solar-wind flux variations in the interplanetary space. The variation of the 44Ti activity with the time of fall of meteorites is qualitatively consistent with the Gleissberg solar cycle, but the amplitude is three-four times higher than expected (about 5%) for GCR flux modulated by solar activity, as determined solely by the sunspot number. The cosmogenic 44Ti is a suitable radioisotope for this investigation, but its activity in meteorites is very low. We performed these measurements in the underground low level counting station of Monte dei Cappuccini in Torino, by means of a big hyperpure Ge crystal (approximately 2 kg) in selective coincidence with a heavy NaI (T1) scintillation detector (approximately 28 kg). This system allows a reliable and non destructive measurement of 44Ti (44Sc) in meteorites of 200-1200 g in weight. The background is about 1 count per day in the gamma-peak at 1157 keV of 44Sc in equilibrium with its parent 44Ti. The high stability of the performance allows long-lasting runs (approximately 10(7) s) in order to attain results with a standard deviation up to about 10%.