Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Molecular spectroscopy of planetary atmospheres

Summary Clearly spectroscopy has already provided considerable insight into the nature of the planetary atmospheres. Several molecular constituents have been positively identified and upper limits have been placed on the abundances of others which are of particular significance in devising planetary models. But, equally clearly, the inadequacy of the spectral data, due to low spectral and/or spatial resolution, renders deductions of abundances, temperatures and pressures very uncertain. With the sole exception of the Martian CO₂ abundance, knowledge of the concentrations of planetary atmospheric constituents is unsatisfactory, and all numbers given must be regarded as only crude estimates. This latter comment applies equally well to the derived temperatures and pressures.What is urgently needed is the development of a reasonably complete theory of line formation in planetary atmospheres. This, coupled with more detailed spectroscopic work, should produce numerical values of atmospheric parameters which can be used with assurance.This work was performed with the aid of NASA Grant NsG-101-61 with funds administered by the University of California.     

Postdetection Integration Loss for Logarithmic Detectors

The effect of a logarithmic receiver on the detection performance of a radar has been determined by Green by numerical computations for up to 100 pulses integrated. It was further suggested that the loss in decibels as compared to a square-law detector would appear to be proportional to the logarithm of the number of pulses integrated. In this correspondence we show that this ?conjecture? is false, and that the additional loss when N becomes very large approaches a constant value of 2.2 dB.     

Use of Airborne Monopulse Radar as a Low Approach Aid

The potential of airborne radar to provide pictorial displays as an aid to low approach has stimulated invention of several aircraft approach systems. Early developments are reviewed briefly, and an experiment in producing and flight testing a two-dimensional, range and azimuth, pictorial radar display is described. The monopulse radar equipment and a monopulse display improvement (MDI) technique used in the flight test to enhance the B-scope display are also described in some detail. Representative radar scope photographs are used to illustrate the display available in the aircraft.     

Biological UV dosimeters in simulated space conditions.

Polycrystalline uracil thin layers participate in the phage and uracil response (PUR) experiment, assigned to the biological dosimetry of the extraterrestrial solar radiation on the International Space Station (ISS). In ground based experiments (experiment verification tests), the following space parameters were simulated and studied: temperature, vacuum and short wavelength UV (UV-C, down to 200 nm) radiation. The closed uracil samples proved to be vacuum-tight for 7 days. In the tested temperature range (from -20 to +40 degrees C) the uracil samples are stable. The kinetic of dimer formation (dimerization) and reversion (monomerization) of uracil dimers due to short wavelength UV radiation was detected, the monomerization efficiency of the polychromatic deuterium lamp is higher than that of the germicidal lamp. A mathematical model describing the kinetic of monomerization-dimerization was constructed. Under the influence of UV radiation the dimerization-monomerization reactions occur simultaneously, thus the additivity law of the effect of the various wavelengths is not applicable.     

Coronal radio-sounding detection of a CME during the 1997 Galileo solar conjunction

Frequency fluctuations of the Galileo S-band radio signal were recorded nearly continuously during the spacecraft’s solar conjunction from December 1996 to February 1997. A strong propagating disturbance, most probably associated with a coronal mass ejection (CME), was detected on 7 February when the radio ray path proximate point was on the west solar limb at about 54 solar radii from the Sun. The CME passage through the line of sight is characterized by a significant increase in the fluctuation intensity of the recorded frequency and by an increase in the plasma speed from about 234 km s⁻¹ up to about 755 km s⁻¹. These velocity estimates are obtained from a correlation analysis of frequency fluctuations recorded simultaneously at two widely-separated ground stations. The density turbulence power spectrum is found to steepen behind the CME front. The Galileo radio-sounding data are compared with SOHO/LASCO observations of the CME in the corona and with WIND spacecraft data near the Earth’s orbit.     

The MELISSA pilot plant facility as as integration test-bed for advanced life support systems.

The different advances in the Micro Ecological Life Support System Alternative project (MELISSA), fostered and coordinated by the European Space Agency, as well as in other associated technologies, are integrated and demonstrated in the MELISSA Pilot Plant laboratory. During the first period of operation, the definition of the different compartments at an individual basis has been achieved, and the complete facility is being re-designed to face a new period of integration of all these compartments. The final objective is to demonstrate the potentiality of biological systems such as MELISSA as life support systems. The facility will also serve as a test bed to study the robustness and stability of the continuous operation of a complex biological system. This includes testing of the associated instrumentation and control for a safe operation, characterization of the chemical and microbial safety of the system, as well as tracking the genetic stability of the microbial strains used. The new period is envisaged as a contribution to the further development of more complete biological life support systems for long-term manned missions, that should be better defined from the knowledge to be gained from this integration phase. This contribution summarizes the current status of the Pilot Plant and the planned steps for the new period.     

Cloudiness over the Eastern Equatorial Pacific for summer 1983 from geostationary satellite data

The extraordinary El-Nino event of 1982–83 started to fade out in the late spring of 1983. However the sea surface temperature of the Eastern Equatorial Pacific still remained warmer than normal in the following summer. To investigate the characteristics of this late transition phase of the 1982–83 El-Nino, the GOES-West satellite data of July and August of 1983 are analyzed. The outgoing longwave radiation field and the distribution of cloudiness, which was derived by using a new threshold technique, are obtained. The longwave radiation field is compared to monthly average climatic indices commonly used at the Climatic Analysis Center. The results of cloud analysis showed some interesting features during the decaying phase of the 1982–83 El-Nino. The diurnal variation of cloudiness indicates that total cloud amounts decrease from 8 GMT to 20 GMT over most of the area. This overall study demonstrates preliminary results of the International Satellite Cloud Climatology Project of the World Climate Research Program.     

Crew autonomy for deep space exploration: Lessons from the Antarctic Search for Meteorites

Future piloted missions to explore asteroids, Mars, and other targets beyond the Moon will experience strict limitations on communication between vehicles in space and control centers on Earth. These limitations will require crews to operate with greater autonomy than any past space mission has demonstrated. The Antarctic Search for Meteorites (ANSMET) project, which regularly sends small teams of researchers to remote parts of the southern continent, resembles a space mission in many ways but does not rely upon a control center. It provides a useful crew autonomy model for planners of future deep space exploration missions. In contrast to current space missions, ANSMET gives the crew the authority to adjust competing work priorities, task assignments, and daily schedules; allows the crew to be the primary monitor of mission progress; demands greater crew accountability for operational errors; requires the crew to make the most of limited communication bandwidth; adopts systems designed for simple operation and failure recovery; and grants the crew a leading role in the selection and stowage of their equipment.