Structural and functional changes in man accompanying the weightlessness in "Skylab" flights: a mathematical approach

The present paper reports a kinetic analysis of changes of some physiological parameters, obtained from international literature, after changes in gravitational environment. The overall phenomenology of the adaptation to weightlessness is characterized by a rapid process followed by a slow one. The two processes show half time values differing by about five times. Also in the case of readaptation to gravity, after recovery on the Earth, two well resolved processes, showing different half time values, are observed. It is of interest to notice that the rate of response to weightlessness is lower than that to gravity. Of course, the half time values observed depend on the different physiological parameters considered. In any case, the experimental data suggest a general trend of many adaptive changes, that may all be described by a simple mathematical model.     

Hydroelectrolytic and hormonal modifications related to prolonged bedrest in antiorthostatic position

The effects of prolonged bedrest in antiorthostatic position (-4 degrees head down) on electrolyte balance were studied in 4 young volunteers. An increase was noted in sodium excretion during the first 4 days. Plasma renin activity and plasma aldosterone varied in parallel manner during the same period. Potassium balance and creatinine clearance were not significantly modified. In light of these data we feel that prolonged bedrest in antiorthostatic position constitutes an effective way to simulate on earth metabolic and hormonal modifications occurring in man under weightlessness conditions.     

Changes in the loco-regional Cerebral Blood Flow (r.C.B.F.) during a simulation of weightlessness.

Experiments of prolonged bedrest in antiorthostatic position are conducted in order to simulated cardio-circulatory modifications observed in weightlessness. Until now, no studies of r.C.B.F. have been effected in these conditions. Six young, healthy volunteers (average age 23.8) were placed in strict bedrest and in antiorthostatic position -4 degrees for 7 days. The r.C.B.F. measurements were studied by 133Xe inhalation method using a 32 detectors system. Studies were made first in basal conditions, then between the 6th and 12th hr, and finally between the 72nd and the 78th hr after the beginning of the experiment. Three of the subjects received 0.450 mg of Clonidine daily during the experiment. In the subjects having taken no Clonidine, we observed a constant increase in r.C.B.F. (12, 17 and 16% respectively) in the first 12 hr; at the 72nd hour, all values had returned to basal state. This findings agrees with the well known notion of a rapid correction of hemodynamic disturbances observed in the first days of weightlessness. In the subjects treated with Clonidine, the increase of r.C.B.F. did not occur. Several mechanisms of action are possible; the Clonidine affecting either the heart by inhibiting volemic atrial receptors or the brain by direct vasoconstriction.     

The Crab pulsar seen with AquEYE at Asiago Cima Ekar observatory

We are developing fast photon-counter instruments to study the rapid variability of astrophysical sources by time tagging photon arrival times with unprecedented accuracy, making use of a Rubidium clock and GPS receiver. The first realization of such optical photon-counters, dubbed AquEYE (the Asiago Quantum Eye), was mounted in 2008 at the 182 cm Copernicus Observatory in Asiago. AquEYE observed the Crab pulsar several times and collected data of extraordinary quality that allowed us to perform accurate optical timing of the Crab pulsar and to study the pulse shape stability on a timescale from days to years with an excellent definition. Our results reinforce the evidence for decadal stability of the inclination angle between the spin and magnetic axis of the Crab pulsar. Future realizations of our instrument will make use of the Galileo Global Navigation Satellite System (GNSS) time signal.     

Italy's contribution, from a medical standpoint, to the space safety of payload scientists, and perspectives for the future

In Italy, the selection of the Italian payload scientists has been performed according to the Spacelab Program of ESA. Twenty-four subjects underwent a screening performed by the Health Service of Italian Air Force. They were requested to pass an exercise test on treadmill and another ten-minute test on centrifuge, subject to the effect of +3 Gz. The authors briefly describe the results of the test. Noteworthy is the determination of Central Flicker Fusion Frequency. This parameter makes it possible to assess the endurance level of the subject, much earlier than other techniques (e.g. EKG). The importance of an accurate preliminary screening is emphasized as well as of successive training periods. Future studies will be undertaken to compare evoked cortical potentials with behaviour parameters of space safety, with a view to setting up a subtle tool of evaluation for both future candidates and payload scientists.     

On the stabilization of ribose by silicate minerals

The RNA-world theory hypothesizes that early Earth life was based on the RNA molecule. However, the notion that ribose, the sugar in RNA, is unstable still casts a serious doubt over this theory. Recently, it has been found that the silicate-mediated formose reaction facilitates the stabilization of ribose. Using accurate quantum chemical calculations, we determined the relative stability of the silicate complexes of arabinose, lyxose, ribose, and xylose with the intent to determine which would form predominantly from a formose-like reaction. Five stereoisomers were investigated for each complex. The stereoisomers of 2:1 ribose-silicate are the more stable ones, to the extent that the least stable of these is even more stable than the most stable stereoisomer of the other 2:1 sugar-silicate complexes. Thus, thermodynamically, a formose-like reaction in the presence of silicate minerals should preferentially form the silicate complex of ribose over the silicate complex of arabinose, lyxose, and xylose.     

Implications of an Engineering Manpower Shortage

Many competent sources have been predicting an increasing shortage of graduate engineers to perform needed research and development work in the United States. Consequently, many industrialists, educators, and government officials have been advocating an increased enrollment of students in the engineering curriculum in college in a greater effort to produce more engineers. This paper examines the assumptions behind the projected manpower shortage, and proposes some rather unique and occasionally radical alternatives to the solution of a manpower deficit. The paper, and the solutions, may produce violent controversy, but at least the material is not the usual dull rehash so often seen of late.     

Effect of non-uniform basic temperature gradient on the onset of Marangoni convection in a fluid with suspended particles

The effect of a non-uniform basic temperature gradient on the onset of convection driven by surface tension in a horizontal layer of a Boussinesq fluid with suspended particles confined between an upper free, constant heat flux boundary and a lower rigid isothermal boundary is considered. The microrotation is assumed to vanish at the boundaries. A linear stability analysis is performed. The Rayleigh–Ritz technique is used to obtain the eigenvalues. The influence of various parameters on the onset of convection has been analyzed. Six different non-uniform basic state temperature profiles are considered and their comparative influence on onset is discussed. It is observed that the fluid layer with suspended particles heated from below is more stable compared to the classical fluid layer without suspended particles. The problem has possible applications in microgravity situations.