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511.
N Desai H Wu K George S R Gonda F A Cucinotta 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2004,34(6):1362-1367
Space flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring. 相似文献
512.
Space technology and activities have changed markedly from the early days of the space era and are continuing to develop rapidly. The TechCast Project—set up to pool the knowledge of experts in the scientific fields—includes space in its predictions. Here its president reports on its space forecasts for the 21st century. The importance of the shift towards the privatization of space is noted and the near-to-medium-term impossibility of interstellar travel conceded. Contact with ETI is deemed much more likely, however. 相似文献
513.
T.K Hei C.Q Piao L.J Wu J.C Willey E.J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1998,22(12):1699-1707
Carcinogenesis is postulated to be a progressive multistage process characterized by an increase in genomic instability and clonal selection with each mutational event endowing a selective growth advantage. Genomic instability as manifested by the amplification of specific gene fragments is common among tumor and transformed cells. In the present study, immortalized human bronchial (BEP2D) cells were irradiated with graded doses of either 1GeV/nucleon 56Fe ions or 150 keV/μm alpha particles. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Tumorigenic cells showed neither ras mutations nor deletion in the p16 tumor suppressor gene. In contrast, they harbored mutations in the p53 gene and over-expressed cyclin D1. Genomic instability among transformed cells at various stage of the carcinogenic process was examined based on frequencies of PALA resistance. Incidence of genomic instability was highest among established tumor cell lines relative to transformed, non-tumorigenic and control cell lines. Treatment of BEP2D cells with a 4 mM dose of the aminothiol WR-1065 significantly reduced their neoplastic transforming response to 56Fe particles. This model provides an opportunity to study the cellular and molecular mechanisms involved in malignant transformation of human epithelial cells by heavy ions. 相似文献
514.
The original basis for the Lorentz transformations, and thus special relativity, was the assumption that the observed velocity of interaction of light with matter represents a unique velocity of the electromagnetic wave. This arbitrary decision is not borne out by Maxwell's theories or by any test that might prove that EM energy actually travels in a continuum of velocities. The second postulate as stated by Einstein does not deserve the status of a postulate, as it is at once overly restrictive and ultimately phenomenological-the nature of c is based on experimental measurement rather than on analysis of first principles. The radiation continuum model's (RCM) modified second postulate, however, says nothing about the actual propagation of EM energy, but only of the relative speed with which it must interact with matter to be detected. Utilizing this modified light principle we obtain an intuitive Galilean form invariance for Maxwell's equations. RCM places no upper limit on attainable velocities, and allows for the possibility of communications between humans or particles at speeds far in excess of c. This precludes many of the compatibility problems between the highly successful quantum mechanics and relativity theory 相似文献
515.
E.H. Lemke 《Acta Astronautica》1985,12(9):647-659
The force on a coil moving with a high-speed parallel to a conducting grid consisting of parallel tubes is investigated. The coil performs a rebound motion or an oscillatory heave motion when pressed toward the grid by reactive on-board engines. The coil is approximated by two parallel wires moving parallel to the grid tubes. The corresponding electrodynamic problem is two dimensional and is solved by expansions in terms of Bessel functions. Expressions are derived for the lift and drag force as well as the heat generated in the tubes in the limit of strong skin effect. The dependence on the grid spacing is analysed in the approximation of no mutual inductance between the tubes. Two specific applications are a shunt deflecting the coil, and a funnel leading to multiple reflection. Finally, the varying magnetic flux threading the coil is considered and the thermal load of the coil is estimated. 相似文献
516.
M.M. Gogoshev Ts.N. Gogosheva I.N. Kostadinov T.I. Markova Sl. Kisyovski 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1985,5(4):213-216
The region of South Atlantic Geomagnetic Anomaly (SAGA) was investigated by the Intercosmos-Bulgaria-1300 satellite, launched on August 7, 1981. On the basis of data obtained from 15 orbits during increased geomagnetic activity in August 1981, a map of the Anomaly was elaborated. Two centres of activity were identified. By means of the EMO-5 electrophotometer on board the Intercosmos-Bulgaria-1300 satellite, the atmosphere glow in lines λ 5577 Å, λ 6300 Å and λ 4278 Å was studied. 相似文献
517.
H.G. Mayr I. Harris F.A. Herrero N.W. Spencer A.E. Hedin R.E. Hartle H.A. Taylor L.E. Wharton F. Varosi H. Volland G.R. Carignan 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1985,5(4):283-288
Thermospheric temperature, composition and wind measurements from the Dynamics Explorer satellite (DE-2) are interpreted using a three dimensional, multiconstituent spectral model. The analysis accounts for tides driven by the absorbed solar radiation as well as energy and momentum coupling involving the magnetosphere and lower atmosphere. We discuss phenomena associated with the annual tide, polar circulation, magnetic storms and substorms. 相似文献
518.
The complex system of linear features on Phobos—the inner moon of Mars—found by the Viking Orbiters in 1976, can be classified morphologically into three types according to their appearance as well as their geometrical distribution on the surface. One kind of grooves appears to form arcs of small circles normal to the Phobos-Mars direction. We propose that these grooves are the surface manifestation of layering within Phobos[4–6] which could have been formed when Phobos was a part of a much larger and geologically active parent planet.Here we suggest some measurements to observe whether Phobos has a layered structure or not. The suggestion contains remote sensing measurements (particularly determination of the magnetic field by magnetometer and by electron reflection method) by a spacecraft orbiting around Mars as well as surface measurements (active seismic reflection experiment) by a landing module on Phobos. 相似文献
519.
H. Fuke J.E. Koglin T. Yoshida T. Aramaki W.W. Craig L. Fabris F. Gahbauer C.J. Hailey F.J. Jou N. Madden K. Mori H.T. Yu K.P. Ziock 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(12):2056-2060
We discuss current progress and future plans for the general antiparticle spectrometer experiment (GAPS). GAPS detects antideuterons through the X-rays and pions emitted during the deexcitation of exotic atoms formed when the antideuterons are slowed down and stopped in targets. GAPS provides an exceptionally sensitive means to detect cosmic-ray antideuterons. Cosmic-ray antideuterons can provide indirect evidence for the existence of dark matter in such form as neutralinos or Kaluza–Klein particles. We describe results of accelerator testing of GAPS prototypes, tentative design concepts for a flight GAPS detector, and near-term plans for flying a GAPS prototype on a balloon. 相似文献