Evaluation of bleomycin-induced chromosome aberrations under simulated microgravity conditions in human lymphocytes using "FISH" techniques

In the present investigation we report the effects of simulated microgravity conditions (clinostat) on the induction of chromosomal aberrations in human lymphocytes in vitro by (R) Bleomycin. Chromosomal aberrations have been analysed by means of fluorescent in situ hybridisation (FISH) and chromosome-specific composite DNA probes (chromosome painting). The results obtained show that, under simulated microgravity conditions, the levels of both symmetrical and asymmetrical (dicentrics, rings), the number of cells bearing "complex" aberrations and hence the total numbers of aberrations were significantly elevated at any of the dose-levels assayed, compared to the parallel treatments performed as 1g control ("ground"). Furthermore, the ratio symmetrical:asymmetrical translocations was markedly elevated under simulated microgravity conditions, compared to the findings usually observed under "normal" 1g conditions. On these bases, we are much inclined to believe that simulated microgravity, rather than limiting the resealing of DNA double strand breaks (DSB's) induced by genotoxic agents is influencing in terms of enhancement the misrejoining of DSB's which is actually responsible for the fixation of the original lesions to DNA into chromosomal aberrations. In addition, the possible different misrepair processes leading to the formation of symmetrical and asymmetrical translocations might be differentially influenced by microgravity being the symmetrical translocations significantly more represented.     

用于新型共形相控阵雷达模块的结构和互连技术

高集成度的收发模块是现代有源相控阵雷达的关键器件。本文描述了一种X波段、带有集成辐射器和环形器的新型收发模块的结构和相关的互连技术。利用这种结构和互连技术，将来可以实现具有小安装厚度的平面或共形有源阵列天线，而且同时具有很高的可维修性。     

《开普敦公约》来到中国

作为一部关于承认在航空器机身、航空器发动机和直升机上的权利的国际公约，《开普敦公约》最初于三年前在八个国家开始实施，如今（截至2009年5月1日）已经在将近30个国家得以施行。     

如何在太空中举办一场晚宴？

即使你已经连续看了这些脸好几个月，你想请人到“你的太空舱”做客，还是只有这些脸。而且必须是所有的……脸。不过。在空间站举办宴会也是有规矩的，要按照接待客人的礼仪接待他们。不能让他们觉得失礼。     

基于目标机动新模型的被动寻的导弹制导律

假设某些目标能作正交于其速度矢量的规避机动,提出一种新的随机动态目标模型.利用增益修正广义卡尔曼滤波器来估计目标状态和在线建立目标机动的角速率.推导出可使二次型性能指标极小化的制导律,对于二维的只有角测量的情况,数值仿真表明,所提出的目标模型会使目标状态的估计得到明显的改进.此外,还给出采用这种新制导方法对终端脱靶距离的影响,并与高斯-马尔可夫模型作了比较.     

英国防部发起新型航空母舰的竞争

日前，英国国防部向全球航空航天制造商发起了价值244亿美元、为英国海军制造两艘航空母舰的竞标活动。有6家公司参与了竞标，它们是波音、英国宇航防御系统、洛克希德、马丁、马可尼电子系统、雷神和汤姆逊一CSF公司。这6家公司都具有较强的海军系统综合能力。但英国政府坚持，新型航空母舰必须在英国制造。计划的第一阶段是在今年秋季选出3家承包商进行初步研究，台问价值830万美元。然后再从中选出两家公司进行减少风险的研究，台同价值3300万美元。最终承包商的确定预计将在2001年，第一艘航空母舰计划于2012年投入使用。该项目由国防…     

靶场标准化及自动化计划第二阶段

一、靶场背景 美国主要的航天发射场,包括东靶场(位于弗罗里达州卡纳维拉尔角)和西靶场(位于加利福尼亚州范登堡空军基地)起源于50年代,在随后的几十年内进行了逐步扩展和改进。直到前不久移交给空军空间司令部时,这些靶场才更多地用作研究和开发单位,而不只是操作运行单位。逐步改造使它们具备了支持发射新型航天器、弹道导弹以及逐步发展起来的     

欧洲的研究和发展计划旨在更清洁的发动机

AVIATIONWEEK》》&SPACETECHNOLOGYEuropeanRεDprojectsTargetCleanerEngines为在未来的民用发动机市场上占更多的份额，欧洲发动机公司正在实施环保型发动机研究计划，目标是大大减少CO。和NOX的排放，并降低拥有费用欧洲委员会已同意投资两项研究计划，旨在为商用飞机研究更清洁和更高效的发动机。这些称为技术平台的飞机发动机计划是根据欧洲委员会研究指挥部第5框架计划进行的，这些计划从2000年到2004年实施，是提高欧洲航字工业竞争性的一系列主要研究和发展计划的首批计划。根据第5框架计划投资的其他技术平台计划…     

Analysis of a spacecraft life support system for a Mars mission

This report summarizes a trade study conducted as part of the Fall 2002 semester Spacecraft Life Support System Design course (ASEN 5116) in the Aerospace Engineering Sciences Department at the University of Colorado. It presents an analysis of current life support system technologies and a preliminary design of an integrated system for supporting humans during transit to and on the surface of the planet Mars. This effort was based on the NASA Design Reference Mission (DRM) for the human exploration of Mars [NASA Design Reference Mission (DRM) for Mars, Addendum 3.0, from the world wide web: http://exploration.jsc.nasa.gov/marsref/contents.html.]. The integrated design was broken into four subsystems: Water Management, Atmosphere Management, Waste Processing, and Food Supply. The process started with the derivation of top-level requirements from the DRM. Additional system and subsystem level assumptions were added where clarification was needed. Candidate technologies were identified and characterized based on performance factors. Trade studies were then conducted for each subsystem. The resulting technologies were integrated into an overall design solution using mass flow relationships. The system level trade study yielded two different configurations--one for the transit to Mars and another for the surface habitat, which included in situ resource utilization. Equivalent System Mass analyses were used to compare each design against an open-loop (non-regenerable) baseline system.