Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments)

Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.     

改善推进剂老化和低温物理性质的键合剂系统

新的混合键合剂系统用于端羟基聚丁二烯推进剂配方时,推进剂的高温老化特性和低温物理性质都有很大改善。混合键合剂系统由 MT_4[2.0克分子三-1-(2-甲基氮丙啶)膦化氧、0.7克分子已二酸和0.3克分子酒石酸的反应产物]、HX752[双-间苯二酰-1-(2-甲基)氨丙啶]和 BIDE(丁基亚胺二乙醇)组成,其重量百分含量分别占推进剂组成的0.10～0.20%、0.10～0.20%和0.02～0.05%。     

螺栓挤压推力终止系统验证试验

本文总结了螺栓挤压推力终止系统(BETTS)的设计、研制和验证试验。该系统在阿诺德工程研制中心(AEDC)进行了多次冷试,一次海平面热试和两次高空点火推力终止试验,试验所用的发动机是政府向化学系统分公司提供的“民兵”发动机空壳体装药后制成的。通过大发动机热试,证明本计划所验证的这种BETTS可以消除前部碎片,大大地简化药柱和发动机壳体的设计,提高末级性能。另外,这种方法设计简单,从而可以降低推进系统的成本。BETTS用爆炸螺栓和挤压螺栓的组合代替连接喷管法兰和发动机壳体法兰的普通螺栓。接到指令后,爆炸螺栓立即打开,喷管循着挤压螺栓向后平移,发动机气体迅速排出,从而使推进剂熄火。挤压螺栓控制着喷管的移动速度和最大运动行程。以前根据NO.F04611—75—C—0044合同(CSD计划2549)曾成功地在缩比发动机上进行了BETTS热试和在飞行重量的“民兵”Ⅲ第三级发动机上进行了冷试。     

On the correlation between individual biochemical parameters of human blood serum following space flight and their basal values

The article presents data concerning the osmolality and concentration of electrolytes and hormones regulating their balance for blood serum of 223 cosmonauts and astronauts. The obtained results allow us to judge the constancy of physicochemical parameters for the blood serum of healthy individuals and how they react to extreme conditions of space flight. The parameters used for evaluation included not just absolute values for the examined indices, but also how they responded to space flight, the dependence on baseline values and the interrelationship between ions. These data are important to predict the effect of exposure to extreme conditions and point to what extent the effect depends on the characteristics of the individual.     

聚合物基复合材料自修复体系的构成与修复机制分析

介绍了聚合物基自修复复合材料的分类、构成及自修复机制,以被动模式的埋植式修复体系为重点进行了详细的分析.在此基础上,提出了一种新的被动模式自修复体系设计.     

一种整体式天然气压缩机气阀故障诊断技术研究CSCD

整体式天然气压缩机在石油化工领域广泛应用,压缩机的正常工作对安全生产具有重要意义。为了有效诊断整体式压缩机气阀部件的故障,采用了Daubechies小波基函数对ZTY470型整体式天然气压缩机气阀振动信号的分解重构原理,详细介绍了以振动信号的能量为故障特征的故障诊断过程。对气阀阀片断裂和弹簧断裂的故障振动信号进行了小波包分析,并与正常工作时的信号进行了对比。实验表明该方法能准确的进行故障诊断和故障定位,证明了对整体式天然气压缩机气阀故障诊断的有效性。     

防务市场疑云笼罩，民用市场乘势起航——《航空周刊》TPC榜单分析

今年5月，《航空周刊》发布了最新的TPC榜单，全面反映了2012年航空航天和国防领域内各企业的综合表现。2012年，虽然全行业取得了创纪录的2％的营业收入和4％的利润增长，但这主要得益于不断攀升的民用市场，而国防工业则经历了相对惨淡的一年。     

French research program on the physiological problems caused by weightlessness. Use of the primate model

The need to acquire a better knowledge of the main biological problems induced by microgravity implies--in addition to human experimentation--the use of animal models, and primates seem to be particularly well adapted to this type of research. The major areas of investigation to be considered are the phospho-calcium metabolism and the metabolism of supporting tissues, the hydroelectrolytic metabolism, the cardiovascular function, awakeness, sleep-awakeness cycles, the physiology of equilibrium and the pathophysiology of space sickness. Considering this program, the Centre d'Etudes et de Recherches de Medecine Aerospatiale, under the sponsorship of the Centre National d'Etudes Spatiales, developed both a program of research on restrained primates for the French-U.S. space cooperation (Spacelab program) and for the French-Soviet space cooperation (Bio-cosmos program), and simulation of the effects of microgravity by head-down bedrest. Its major characteristics are discussed in the study.     

On the possibility of Earth-type habitable planets in the 55 Cancri system

We discuss the possibility of Earth-type planets in the planetary system of 55 Cancri, a nearby G8 V star, which is host to two, possibly three, giant planets. We argue that Earth-type planets around 55 Cancri are in principle possible. Several conditions are necessary. First, Earth-type planets must have formed despite the existence of the close-in giant planet(s). In addition, they must be orbitally stable in the region of habitability considering that the stellar habitable zone is relatively close to the star compared to the Sun because of 55 Cancri's low luminosity and may therefore be affected by the close-in giant planet(s). We estimate the likelihood of Earth-type planets around 55 Cancri based on the integrated system approach previously considered, which provides a way of assessing the long-term possibility of photosynthetic biomass production under geodynamic conditions.