Blood volume regulating hormones response during two space related simulation protocols: four-week confinement and head-down bed-rest

The volume of regulating hormones (renin, aldosterone, arginine vasopressin and atrial natriuretic factor), electrolytes and creatinine concentrations, and blood pressure were measured in two different four-week experimental protocols: respectively -6 degrees head-down bed-rest (5 subjects) and confinement (6 subjects). We observed a significant increase (P < 0.01 at D2 vs D-5) of systolic blood pressure during confinement and a different level of response for some hormones, especially for arginine vasopressin (300% increase during confinement instead of 50% during bed-rest). The renin-angiotensin-aldosterone system was enhanced during confinement and head-down bed-rest. In both conditions, we obtained a similar pattern of response for blood volume regulating hormones. During confinement, two main factors were inactivity and stress activation of the sympathetic nervous system. In the bed-rest study the response is principally due to the fluid shift and blood volume adaptation but it is not possible to exclude the role of inactivity and stress.     

New ideas for affordable space missions

In September 1995, NASA-Goddard held a workshop on low-cost access to space for science missions. The workshop provided briefings on balloons, sounding rockets, Shuttle payloads, and low-cost free-flyer concepts, to provide options of getting experiments into space. This report is the result of a panel session organized with the aim of generating new ideas beyond those presented in the workshop. In addition to the authors, Orlando Figueroa and Paul Ondrus of NASA-Goddard and Richard Zwirnbaum of Computer Sciences Corp. participated in the discussions. The ideas presented do not necessarily reflect the current thinking of NASA managers. Although the panel discussion was focused on the kinds of science missions usually funded by NASA, most of the ideas that were generated are relevant to military and commercial missions as well.     

Investigations onboard the biosatellite Cosmos-1667

The program of the 7-day flight of the biosatellite Cosmos-1667 launched in July 1985 included experiments on two rhesus monkeys, ten Wistar SPF rats, ten newts, Drosophila flies, maize seedlings, lettuce sprouts, and unicellular organisms - Tetrahymena. The primate study demonstrated that transition to orbital flight was accompanied by a greater excitability of the vestibular apparatus and an increased linear blood flow velocity in the common carotid artery. The rat studies showed that atrophy of antigravity muscles and osteoporosis of limb bones developed even during short-term exposure to microgravity. The experiments on other living systems revealed no microgravity effects on the cell division rate, proliferative activity of cells of regenerating tissues and organs, energy metabolism of developing insects, structure or chemical composition of higher plant seedlings.     

COMPTEL observations of AGNs

During the first part of the COMPTON Gamma Ray Observatory sky survey, COMPTEL has detected the quasars 3C273 and 3C279 and the radio galaxy Centaurus A. This paper summarizes the preliminary findings and gives an upper limit on the MeV flux of the Seyfert galaxy NGC4151.     

Studying the evolution of the hot universe with the X-ray evolving universe spectroscopy mission – XEUS

Europe is one of the major partners building the International Space Station (ISS) and European industry, together with ESA, is responsible for many station components including the Columbus Orbital Facility, the Automated Transport Vehicle, two connecting modules and the European Robotic Arm. Together with this impressive list of contributions there is a strong desire within the ESA Member States to benefit from this investment by utilizing the unique capabilities of the ISS to perform world-class science. XEUS is one of the astronomical applications being studied by ESA to utilize the capabilities of the ISS. XEUS will be a long-term X-ray observatory with an initial mirror area of 6 m² at 1 keV that will be expanded to 30 m² following a visit to the ISS. The 1 keV spatial resolution is expected to be 2–5″ half-energy-width. XEUS will consist of separate detector and mirror spacecraft (MSC) aligned by active control to provide a focal length of 50 m. A new detector spacecraft, complete with the next generation of instruments, will also be added after visiting the ISS. The limiting 0.1–2.5 keV sensitivity will then be 4 × 10⁻¹⁸ erg cm⁻² s⁻¹, around 200 times better than XMM-Newton, allowing XEUS to study the properties of the hot baryons and dark matter at high redshift.     

Solar orbiter, a high-resolution mission to the sun and inner heliosphere

The scientific rationale of the Solar Orbiter is to provide, at high spatial (35 km pixel size) and temporal resolution, observations of the solar atmosphere and unexplored inner heliosphere. Novel observations will be made in the almost heliosynchronous segments of the orbits at heliocentric distances near 45 R and out of the ecliptic plane at the highest heliographic latitudes of 30° – 38°. The Solar Orbiter will achieve its wide-ranging aims with a suite of sophisticated instruments through an innovative design of the orbit. The first near-Sun interplanetary measurements together with concurrent remote observations of the Sun will permit us to determine and understand, through correlative studies, the characteristics of the solar wind and energetic particles in close linkage with the plasma and radiation conditions in their source regions on the Sun. Over extended periods the Solar Orbiter will deliver the first images of the polar regions and the side of the Sun invisible from the Earth.     

Investigation of magnetospheric processes with the use of a source of strong magnetic field in the ionosphere

More than 20 years ago V.P. Shabansky suggested that the magnetic system installed aboard the satellite, could be used as a physical instrument for studying the processes which occur in the near Earth space. The corresponding space scales of an artificial “magnetosphere”—“magnisphere”—are 10 m in the experiment with relatively small magnets in the ionosphere and 100 m in the solar wind. The corresponding similarity criteria are estimated. The possible scheme of the experiment with a superconducting magnet (magnetic moment 10⁵ A · m²) installed aboard the satellite is considered. The experimental complex includes a number of systems for measuring the fluxes of charged particles in a wide energy range, DC electric and magnetic fields, the electromagnetic fields in different frequency bands (from X-rays to radio). The scientific objectives are discussed in detail.     

Radar detection of subsurface features on Mars

The structure of the pulse radar signal reflected from continuously changing layered Martian crust is investigated theoretically. As a simple model of stratigraphy, we considered one layer with electrodynamics’ parameters increasing or decreasing exponentially upon a depth laying on monolith base and covered by homogeneous layer. This exponential changing of electromagnetic properties of the layer is assumed due to exponential changing of porosity (or saturation) in the bedrocks with pores filled by seawater. The conditions of subsurface features resolution are obtained. It is shown that the sign and value for gradient of the electromagnetic properties change can be resolved from the reflection peaks trend. These results are important for subsurface detection of liquid water on Mars by orbit-based radars.     

Biological dosimetry in Russian and Italian astronauts.

Large uncertainties are associated with estimates of equivalent dose and cancer risk for crews of long-term space missions. Biological dosimetry in astronauts is emerging as a useful technique to compare predictions based on quality factors and risk coefficients with actual measurements of biological damage in-flight. In the present study, chromosomal aberrations were analyzed in one Italian and eight Russian cosmonauts following missions of different duration on the MIR and the international space station (ISS). We used the technique of fluorescence in situ hybridization (FISH) to visualize translocations in chromosomes 1 and 2. In some cases, an increase in chromosome damage was observed after flight, but no correlation could be found between chromosome damage and flight history, in terms of number of flights at the time of sampling, duration in space and extra-vehicular activity. Blood samples from one of the cosmonauts were exposed in vitro to 6 MeV X-rays both before and after the flight. An enhancement in radiosensitivity induced by the spaceflight was observed.