Skylab experiment results: hematology studies

These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.     

Drying as one of the extreme factors for the microflora of the atmosphere

An investigation of the effects of drying and drying-rewetting cycles under vacuum conditions of 10(-2) torr at -30 degrees C on conidia of the atmospheric strain Penicillium chrysogenum from 48-77 km heights, collected by meteorological rockets found that survival and restoration of the initial physiological properties were possible through some very efficient protective cellular mechanisms. Such adaptive possibilities explain the widespread diffusion of microbial cells throughout the biosphere of our planet.     

Study of radiation conditions onboard the International space station by means of the Liulin-5 dosimeter

For estimating radiation risk in space flights it is necessary to determine radiation dose obtained by critical organs of a human body. For this purpose the experiments with human body models are carried out onboard spacecraft. These models represent phantoms equipped with passive and active radiation detectors which measure dose distributions at places of location of critical organs. The dosimetric Liulin-5 telescope is manufactured with using three silicon detectors for studying radiation conditions in the spherical tissue-equivalent phantom on the Russian segment of the International space station (ISS). The purpose of the experiment with Liulin-5 instrument is to study dynamics of the dose rate and particle flux in the phantom, as well as variations of radiation conditions on the ISS over long time intervals depending on a phase of the solar activity cycle, orbital parameters, and presence of solar energetic particles. The Liulin-5 dosimeter measures simultaneously the dose rate and fluxes of charged particles at three depths in the radial channel of the phantom, as well as the linear energy transfer. The paper presents the results of measurements of dose rate and particle fluxes caused by various radiation field components on the ISS during the period from June 2007 till December 2009.     

The Soviet manned lunar programme and its legacy

In the last two years the USSR has not only acknowledged publicly for the first time that it was trying to ‘race’ the USA to put the first man on the Moon, but they have finally given some details of the programme, the equipment and the political in-fighting which ensured that the programme was a failure. This article traces the history of the Soviet manned lunar programme and also discusses the implications for the future development of the Soviet manned programme of the giant N-1 booster's cancellation in 1974.     

Aqueous corrosion of phosphide minerals from iron meteorites: a highly reactive source of prebiotic phosphorus on the surface of the early Earth

We present the results of an experimental study of aqueous corrosion of Fe-phosphide under conditions relevant to the early Earth. The results strongly suggest that iron meteorites were an important source of reactive phosphorus (P), a requirement for the formation of P-based life. We further demonstrate that iron meteorites were an abundant source of phosphide minerals early in Earth history. Phosphide corrosion was studied in five different solutions: deionized water, deionized water buffered with sodium bicarbonate, deionized water with dissolved magnesium and calcium chlorides, deionized water containing ethanol and acetic acid, and deionized water containing the chlorides, ethanol, and acetic acid. Experiments were performed in the presence of both air and pure Ar gas to evaluate the effect of atmospheric chemistry. Phosphide corrosion in deionized water results in a metastable mixture of mixed-valence, P-bearing ions including pyrophosphate and triphosphate, key components for metabolism in modern life. In a pH-buffered solution of NaHCO(3), the condensed and reduced species diphosphonate is an abundant corrosion product. Corrosion in ethanol- and acetic acid-containing solutions yields additional P-bearing organic molecules, including acetyl phosphonate and a cyclic triphosphorus molecule. Phosphonate is a major corrosion product of all experiments and is the only P-bearing molecule that persists in solutions with high concentrations of magnesium and calcium chlorides, which suggests that phosphonate may have been a primitive oceanic source of P. The stability and reactivity of phosphonate and hypophosphite in solution were investigated to elucidate reaction mechanisms and the role of mineral catalysts on P-solution chemistry. Phosphonate oxidation is rapid in the presence of Fe metal but negligible in the presence of magnetite and in the control sample. The rate of hypophosphite oxidation is independent of reaction substrate.     

Metabolic assessments during extra-vehicular activity

Extra-vehicular activity (EVA) has a significant role during extended space flights. It demonstrates that humans can survive and perform useful work outside the Orbital Space Stations (OSS) while wearing protective space suits (SS). When the International Space Station 'Alpha' (ISSA) is fully operational, EVA assembly, installation, maintenance and repair operations will become an everyday repetitive work activity in space. It needs new ergonomic evaluation of the work/rest schedule for an increasing of the labor amount per EVA hour. The metabolism assessment is a helpful method to control the productivity of the EVA astronaut and to optimize the work/rest regime. Three following methods were used in Russia to estimate real-time metabolic rates during EVA: 1. Oxygen consumption, computed from the pressure drop in a high pressure bottle per unit time (with actual thermodynamic oxygen properties under high pressure and oxygen leakage taken into account). 2. Carbon dioxide production, computed from CO2 concentration at the contaminant control cartridge and gas flow rate in the life support subsystem closed loop (nominal mode) or gas leakage in the SS open loop (emergency mode). 3. Heat removal, computed from the difference between the temperatures of coolant water or gas and its flow rate in a unit of time (with assumed humidity and wet oxygen state taken into account). Comparison of heat removal values with metabolic rates enables us to determine the thermal balance during an operative medical control of EVA at "Salyut-6", "Salyut-7" and "Mir" OSS. Complex analysis of metabolism, body temperature and heat rate supports a differential diagnosis between emotional and thermal components of stress during EVA. It gives a prognosis of human homeostasis during EVA. Available information has been acquired into an EVA data base which is an effective tool for ergonomical optimization.     

Influence of Trapped Plasma on the Structure of Collisionless Thin Current Sheets

Using both analytical and numerical models of the collisionless anisotropic current sheet generated by the impinging flows of transient ions, we have studied the self-consistent solutions taking the plasma trapped in the sheet into account. It is demonstrated that there exists a limited window in the space of system parameters where self-consistent solutions can exist. When the density of the quasi-trapped plasma is sufficiently large, a redistribution of the total current can be a cause of the sheet decay, when the local current of the trapped particles compensate (totally or in part) the main current in the center and at the edges of the sheet, while the total current generated by ions on the trapped trajectories vanishes.     

Radio Occultation Measurements of the Radio Wave Absorption and the Sulfuric Acid Vapor Content in the Atmosphere of Venus

The results of the determination of centimeter ( = 5 cm) radio waves absorption in the radio occultation experiments, carried out using the Venera-15and Venera-16spacecraft, are presented. The altitude distribution of the absorber substance is analyzed. The absorbing layer is shown to exist at altitudes of 64 to 58 km in the near-polar regions of the planet. At middle latitudes such an absorbing layer was not found. In the altitude range from 56 to 46 km the radio wave absorption by the sulfuric acid (H₂SO₄) vapor is observed. The content of the sulfuric acid vapor is shown to increase with decreasing altitude: in the mid-latitude region at altitudes of 56.7 and 53 km it equals 5 and 20 ppm, respectively, and at polar latitudes the same content of H₂SO₄vapor is observed at altitudes of 51.2 and 47 km, respectively. A comparison of these results with the data of radio wave absorption in the = 13 cm band, obtained in the Pioneer Venus Orbiterradio occultation experiments, leads to the conclusion that the obtained values of the sulfuric acid vapor content well agree in the regions of overlap of the data.     

Effect of volatile metabolites of dill, radish and garlic on growth of bacteria

In a model experiment plants were grown in sealed chambers on expanded clay aggregate under the luminance of 150 W/m2 PAR and the temperature of 24 degrees C. Seven bacterial strains under investigation, replicated on nutrient medium surface in Petri dishes, were grown in the atmosphere of cultivated plants. Microbial response was evaluated by the difference between colony size in experiment and in control. In control, bacteria grew in the atmosphere of clean air. To study the effects of volatile metabolites of various plant on microbial growth, the experimental data were compared with the background values defined for each individual experiment. Expanded clay aggregate, luminance, temperature, and sealed chamber (without plants) for the background were the same. Volatile metabolites from 28-days old radish plants have been reliably established to have no effect on the growth of microbes under investigation. Metabolites of 30-days old dill and 50-days old garlic have been established to have reliable bacteriostatic effect on the growth of three bacterial strains. Dill and garlic have been found to have different range of effects of volatile substances on bacterial growth. Volatile metabolites of dill and garlic differed in their effect on the sensitivity spectrum of bacteria. An attempt has been made to describe the obtained data mathematically.