The sopite syndrome revisited: drowsiness and mood changes during real or apparent motion

The sopite syndrome is a poorly understood response to motion. Drowsiness and mood changes are the primary characteristics of the syndrome. The sopite syndrome can exist in isolation from more apparent symptoms such as nausea, can last long after nausea has subsided, and can debilitate some individuals. It is most likely a distinct syndrome from "regular" motion sickness or common fatigue, and is of potential concern in a variety of situations. The syndrome may be particularly hazardous in transportation settings where other performance challenges (e.g., sleep deprivation) are already present. It is also a potential concern in cases where illnesses such as sleep disorders or depression may interact with the syndrome and confuse diagnosis.     

Cellular responses to gravity: extracellular, intracellular and in-between.

Our understanding of gravitational effects (inertial effects in the vicinity of 1 x g) on cells has matured to a stage at which it is possible to define, on the basis of experimental evidence, extracellular effects on small cells and intracellular effects on eukaryotic gravisensing cells. Yet undetermined is the nature of response, if any, of those classes of cells that are not governed solely by extracellular physical events (as are prokaryotes) and are devoid of obvious mechanical devices for sensing inertial forces (such as those possessed by certain plant cells and sensory cells of animals). This "in-between" class of cells needs to be understood on the basis of the combination of intracellular and extracellular gravity-dependent processes that govern experimentally-measurable variables that are relevant to the cell's responses to modified inertial forces. The forces that certain cell types generate or respond to are therefore compared to those imposed by approximately 1 x g in the context of cytoskeletal action and symmetry-breaking pathways.     

Radio fine structures in dm–cm wavelength range associated with magnetic reconnection processes

Radio bursts with fine structures in decimetric–centimetric wave range are generally believed to manifest the primary energy release process during flare/CME events. By spectropolarimeters in 1–2 GHz, 2.6–3.8 GHz, and 5.2–7.6 GHz at NAOC/Huairou with very high temporal (1.25–8 ms) and spectral (4–20 MHz) resolutions, the zebra patterns, spikes, and new types of radio fine structures with mixed frequency drift features are observed during several significant flare/CME events. In this paper we will discuss the occurrence of radio fine structures during the impulsive phase of flares and/or CME initiations, which may be connected to the magnetic reconnection processes.     

Vertical motions in Thailand after the 2004 Sumatra–Andaman Earthquake from GPS observations and its geophysical modelling

Following previous findings from ongoing GPS research in Thailand since 2004 we continue to exploit the GPS technique to monitor and model land motions induced by the Sumatra–Andaman Earthquake. Our latest results show that up to the end of 2010, Thailand has been co-seismically displaced and is subsequently undergoing a post-seismic horizontal deformation with total displacements (co-seismic plus post-seismic) ranging from 10.5 to 74.7 cm. We observed the largest horizontal displacements in the southern part of Thailand and moderate and small displacements in the central and northern parts. In addition to horizontal displacements throughout Thailand, continuous GPS measurements show that large parts of Thailand are subsiding at rates up to 1 cm/yr. It is the first time that such vertical post-seismic deformations at large distances (650–1500 km away from the Earthquake’s epicentre) have been recorded. We have investigated the physical processes leading to the observed subsidence. While after-slip on the subduction interface induces negligible or even slightly positive vertical motions, relaxation in the asthenosphere is associated with a sizable subsidence. Predictions from a 3D finite element model feature an asthenosphere with an effective viscosity of the order of 3 * 10¹⁸ Pas, fit the horizontal post-seismic data and the observed subsidence well. This model is then used to predict the subsidence over the whole seismic cycle. The subsidence should go on with a diminishing rate through the next two decades and its final magnitude should not exceed 10 cm in the Bangkok area.     

Trapped proton fluxes measured on board LEO satellites in comparison with models

The proton fluxes from the low-Earth orbital satellites databases (NPOES-17 and CORONAS-F) were analyzed for the quiet geomagnetic period in April 2005. The satisfactory consent was found between the experimental and the AP8 model fluxes of the trapped protons with energy more than ∼10 MeV. At the same time, trapped proton fluxes with energy less than 10 MeV measured by LEO satellites were higher than the ones predicted by the AP8 model in the region of the SAA (drift shell L < 1.5).     

Emesis and space motion sickness in amphibians.

Amphibians possess the ability to vomit in response to a variety of stimuli that provoke emesis in mammals. Pharmacological studies have establish that the ejection of gastric contents and the basic mechanism for vomiting have been phylogenetically conserved among these tetrapods. As part of on-going comparative studies on emesis in vertebrates, we previously documented that some postmetamorphic anurans and salamander larvae experience motion-induced emesis when exposed to the provocative stimulus of parabolic aircraft flight. However, more recent experiments suggest that there are strict conditions for inducing emesis in amphibians exposed to parabolic flight and that amphibians are not as sensitive to this stimulus as mammals. Further studies on emesis in lower vertebrates may help us understand the processes that cause emesis in abnormal gravitational regimes.     

The human cardiovascular system during space flight

Purpose of the work is to analyze and to summarize the data of investigations into human hemodynamics performed over 20 years aboard orbital stations Salyut-7 and Mir with participation of 26 cosmonauts on space flights (SF) from 8 to 438 days in duration. The ultrasonic techniques and occlusive plethysmography demonstrated dynamics of changes in the cardiovascular system during SF of various durations. The parameters of general hemodynamics, the pumping function of the heart and arterial circulation in the brain remained stable in all the space flights; however, there were alterations in peripheral circulation associated with blood redistribution and hypovolemie in microgravity. The anti-gravity distribution of the vascular tone decayed gradually as unneeded. The most considerable changes were observed in leg vessels, equally in arteries (decrease in resistance) and veins (increase in maximum capacity). The lower body negative pressure test (LBNP) revealed deterioration of the gravity-dependent reactions that changed for the worse as SF duration extended. The cardiovascular deconditioning showed itself as loss of descent acceleration tolerance and orthostatic instability in the postflight period.     

Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition

Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.