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391.
T.K Hei C.Q Piao L.J Wu J.C Willey E.J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1998,22(12):1699-1707
Carcinogenesis is postulated to be a progressive multistage process characterized by an increase in genomic instability and clonal selection with each mutational event endowing a selective growth advantage. Genomic instability as manifested by the amplification of specific gene fragments is common among tumor and transformed cells. In the present study, immortalized human bronchial (BEP2D) cells were irradiated with graded doses of either 1GeV/nucleon 56Fe ions or 150 keV/μm alpha particles. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Tumorigenic cells showed neither ras mutations nor deletion in the p16 tumor suppressor gene. In contrast, they harbored mutations in the p53 gene and over-expressed cyclin D1. Genomic instability among transformed cells at various stage of the carcinogenic process was examined based on frequencies of PALA resistance. Incidence of genomic instability was highest among established tumor cell lines relative to transformed, non-tumorigenic and control cell lines. Treatment of BEP2D cells with a 4 mM dose of the aminothiol WR-1065 significantly reduced their neoplastic transforming response to 56Fe particles. This model provides an opportunity to study the cellular and molecular mechanisms involved in malignant transformation of human epithelial cells by heavy ions. 相似文献
392.
Chin-Chun Wu R.P. Lepping 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(2):335-338
Using nine years (1995–2003) of solar wind plasma and magnetic field data, solar sunspot number, and geomagnetic activity data, we investigated the geomagnetic activity associated with magnetic clouds (MCs), magnetic cloud-like structures (MCLs), and interplanetary shock waves. Eighty-two MCs and one hundred and twenty-two MCLs were identified by using solar wind and magnetic field data from the WIND mission, and two hundred and sixty-one interplanetary shocks were identified over the period of 1995–2003 in the vicinity of Earth. It is found that MCs are typically more geoeffective than MCLs or interplanetary shocks. The occurrence frequency of MCs is not well correlated with sunspot number. By contrast, both occurrence frequency of MCLs and sudden storm commencements (SSCs) are well correlated with sunspot number. 相似文献
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ATC 模拟系统是一个比较复杂的,实时性很强的控制系统,要求整个系统的可靠性很高。而对于一个系统来讲,其中央存贮系统是保证整个系统正常工作的关键部件之一。在我们引进的系统中,它的容错技术在设计上有其独到之处。本文就其存贮系统的结构、容错技术及支持电路这三部分予以说明和论述,仅供同行参考。 相似文献
395.
Flow separation control on swept wing with nanosecond pulse driven DBD plasma actuators 总被引:3,自引:2,他引:1
A 15° swept wing with dielectric barrier discharge plasma actuator is designed.Experimental study of flow separation control with nanosecond pulsed plasma actuation is performed at flow velocity up to 40 m/s. The effects of the actuation frequency and voltage on the aerodynamic performance of the swept wing are evaluated by the balanced force and pressure measurements in the wind tunnel. At last, the performances on separation flow control of the three types of actuators with plane and saw-toothed exposed electrodes are compared. The optimal actuation frequency for the flow separation control on the swept wing is detected, namely the reduced frequency is 0.775, which is different from 2-D airfoil separation control. There exists a threshold voltage for the low swept wing flow control. Before the threshold voltage, as the actuation voltage increases, the control effects become better. The maximum lift is increased by 23.1% with the drag decreased by 22.4% at 14°, compared with the base line. However, the best effects are obtained on actuator with plane exposed electrode in the low-speed experiment and the abilities of saw-toothed actuators are expected to be verified under high-speed conditions. 相似文献
396.
Numerical investigations on the launch process of a gun-launched missile from the muzzle of a cannon to the free-flight stage have been performed in this paper. The dynamic overlapped grids approach are applied to dealing with the problems of a moving gun-launched missile. The high-resolution upwind scheme(AUSMPW+) and the detailed reaction kinetics model are adopted to solve the chemical non-equilibrium Euler equations for dynamic grids. The development process and flow field structure of muzzle flows including a gun-launched missile are discussed in detail.This present numerical study confirms that complicated transient phenomena exist in the shortly launching stages when the gun-launched missile moves from the muzzle of a cannon to the freeflight stage. The propellant gas flows, the initial environmental ambient air flows and the moving missile mutually couple and interact. A complete structure of flow field is formed at the launching stages, including the blast wave, base shock, reflected shock, incident shock, shear layer, primary vortex ring and triple point. 相似文献
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基于左手材料的翼面隐身结构设计及优化 总被引:1,自引:0,他引:1
翼面隐身结构能同时满足飞行器机翼气动、结构和隐身的要求,但在空间有限的机翼中应用时,由于结构特点使其隐身效果受到限制。为了解决该问题,在传统隐身结构中加入左手材料(LHM)进行改进。首先选取一种典型的LHM,从隐身设计角度出发,利用其雷达散射截面(RCS)计算不同入射角度下的后向吸收率,对其电磁特性进行研究。然后根据LHM的电磁特性,将其应用于翼面隐身结构,在相同的RCS减缩效果下,应用LHM可有效降低隐身结构体积。最后,为了进一步提高隐身效果,提出一种夹芯型LHM翼面隐身结构,并对该隐身结构中的结构参数利用代理模型进行优化。研究结果表明,相较金属翼面段RCS降低了15dB以上,较相同结构的翼面隐身结构RCS降低了10dB以上。 相似文献
400.
This paper studies a nonlinear robust control algorithm of the electro-hydraulic load simulator (EHLS). The tracking performance of the EHLS is mainly limited by the actuator's motion disturbance, flow nonlinearity, and friction, etc. The developed controller is developed based on the nonlinear motion loading model. The problems of the actuator's disturbance and flow nonlinearity are considered. To address the friction problem, the friction model of the loading motor is identified experimentally. The friction disturbance is compensated using the obtained friction model. Therefore, this paper considers the main three factors comprehensively. The developed algorithm is easy to apply since the controller can be obtained just with one step back-stepping design. The stability of the developed algorithm is proven via Lyapunov analysis. Both co-simulation and experiments are performed to verify the effectiveness of this method. 相似文献