Genomic instability and tumorigenic induction in immortalized human bronchial epithelial cells by heavy ions

Carcinogenesis is postulated to be a progressive multistage process characterized by an increase in genomic instability and clonal selection with each mutational event endowing a selective growth advantage. Genomic instability as manifested by the amplification of specific gene fragments is common among tumor and transformed cells. In the present study, immortalized human bronchial (BEP2D) cells were irradiated with graded doses of either 1GeV/nucleon ⁵⁶Fe ions or 150 keV/μm alpha particles. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Tumorigenic cells showed neither ras mutations nor deletion in the p16 tumor suppressor gene. In contrast, they harbored mutations in the p53 gene and over-expressed cyclin D1. Genomic instability among transformed cells at various stage of the carcinogenic process was examined based on frequencies of PALA resistance. Incidence of genomic instability was highest among established tumor cell lines relative to transformed, non-tumorigenic and control cell lines. Treatment of BEP2D cells with a 4 mM dose of the aminothiol WR-1065 significantly reduced their neoplastic transforming response to ⁵⁶Fe particles. This model provides an opportunity to study the cellular and molecular mechanisms involved in malignant transformation of human epithelial cells by heavy ions.     

温度翘曲应力对机场刚性道面寿命的影响

分析了目前中国民航机场刚性道面的设计过程,指出在设计过程中忽视温度应力的影响不合理。参照公路水泥混凝土路面温度应力计算方法并根据Miner定律研究了温度翘曲疲劳损耗对于机场刚性道面影响规律,即温度翘曲疲劳损耗随板厚、地基反应模量的增大而增大,随着混凝土设计强度的增加而降低。然后提出采用设计寿命的影响因子nt/Nt评价温度翘曲疲劳损耗对于机场刚性道面设计寿命影响的方法并提供了相应的机场刚性道面板厚度设计流程图。最后提供了一个考虑温度翘曲应力的刚性道面设计实例,为工程应用提供参考。     

Geomagnetic activity associated with magnetic clouds,magnetic cloud-like structures and interplanetary shocks for the period 1995–2003

Using nine years (1995–2003) of solar wind plasma and magnetic field data, solar sunspot number, and geomagnetic activity data, we investigated the geomagnetic activity associated with magnetic clouds (MCs), magnetic cloud-like structures (MCLs), and interplanetary shock waves. Eighty-two MCs and one hundred and twenty-two MCLs were identified by using solar wind and magnetic field data from the WIND mission, and two hundred and sixty-one interplanetary shocks were identified over the period of 1995–2003 in the vicinity of Earth. It is found that MCs are typically more geoeffective than MCLs or interplanetary shocks. The occurrence frequency of MCs is not well correlated with sunspot number. By contrast, both occurrence frequency of MCLs and sudden storm commencements (SSCs) are well correlated with sunspot number.     

制造业IT生产力优化

分析了制造业企业在IT系统建设方面遇到的困境以及进行企业IT生产力优化的必要性,提出了企业进行IT生产力优化的基本方法体系,阐释了利用面向服务的架构(SOA)、开放组织架构框架(TOGAF)、ESB模式构建灵活稳健的企业IT架构的技术路线,并给出了针对制造业的解决方案参考模型。     

中间件技术的研究及应用

本文在分析了分布式应用系统体系结构发展变化的基础上．阐述了中间件的概念、功能和在可重用、多异构数据源应用系统的作用，对ODBC、BDE／IDAPIT、0LEDB／ADO和JDBC等分布式数据库中间件；CGI、lSAPI／NSAPI、ASP、JSP等中间件进行了分析比较，并给出了中间件技术在教务管理信息系统的应用实例。     

Weeden and Chow: Commentary from a legal perspective

The paper, ‘Space sustainability through the sustainable management of common-pool resources: a framework and potential policies’ by Brian Weeden and Tiffany Chow, researches Long-Term Sustainability issues (LTS) from the perspectives of both economics and governance, focusing on analyzing Elinor Ostrom's principles, and puts forward the main elements for a management regime. Their paper will be helpful for the international community to understand the importance of LTS, to further discussions in this field and even to shape a framework for tackling LTS. On the other hand, some of the principles raised by Ostrom still need to be clarified and deliberated throughout the international community. This commentary will analyze some of Ostrom's principles from the perspective of the 1967 Outer Space Treaty (OST) and put forward the values LTS should encompass based on an analysis of its relations with provisions in the OST.     

UWBR和HPMW一体化设计探讨

简述了美国雷达武器化的研究现状；介绍了超宽带雷达（UWBR）和高功率微波武器（HPMW）的组成、基本原理；结合国内外现有技术成果，分析了UWBR和HPMW一体化设计的可行性；参照数字阵列雷达，提出了一种UWBR和HPMW一体化概念设计结构图，并重点讨论了一体化设计的难点及关键技术。     

芳纶复合材料用湿法环氧配方的研究

在综合考虑粘度，力学性能和储存期的基础上，研制了以混合芳香胺为固化剂的芳纶用湿法环氧配方， 注浇体力学与俄，美等国家湿法环配方及我国高性能干法配方性能相当，实验证明该湿法环氧配方与Ｆ－１２纤维浸润性及界面粘接性能均较高，其ＮＯＬ环强度转化率均达８７％。     

Robust adaptive fault-tolerant control of a tandem coaxial ducted fan aircraft with actuator saturation

This paper is concerned with the robust adaptive fault-tolerant control of a tandem coaxial ducted fan aircraft under system uncertainty, mismatched disturbance, and actuator saturation. For the proposed aircraft, comprehensive controllability analysis is performed to evaluate the controllability of each state as well as the margin to reject mismatched disturbance without any knowledge of the controller. Mismatched disturbance attenuation is ensured through a structured H-infinity controller tuned by a non-smooth optimization algorithm. Embedded with the H-infinity controller, an adaptive control law is proposed in order to mitigate matched system uncertainty and actuator fault. Input saturation is also considered by the modified reference model. Numerical simulation of the novel ducted fan aircraft is provided to illustrate the effectiveness of the proposed method. The simulation results reveal that the proposed adaptive controller achieves better transient response and more robust performance than classic Model Reference Adaptive Control (MRAC) method, even with serious actuator saturation.     

ATC模拟系统中存贮系统的容错技术

ATC 模拟系统是一个比较复杂的,实时性很强的控制系统,要求整个系统的可靠性很高。而对于一个系统来讲,其中央存贮系统是保证整个系统正常工作的关键部件之一。在我们引进的系统中,它的容错技术在设计上有其独到之处。本文就其存贮系统的结构、容错技术及支持电路这三部分予以说明和论述,仅供同行参考。