Searching for the magic bullet

A powerful statistical tool, paired-comparison, was tested as a method to determine the relative value American people place on two possibly competing paradigms in the United States Space Program: “Space as a Place to Explore” and “Civil and Commercial Uses of Space”. A limitation of the results, but not the methodology, is the participants were college students, not “voting” adults. Reliability and validity of items were developed and tested in two studies suggesting that the paired-comparison method is a reliable and powerful tool for measuring the relative value the public may place on programs within the US Space Program.     

The dynamics of blood biochemical parameters in cosmonauts during long-term space flights

Most of the previously obtained data on cosmonauts' metabolic state concerned certain stages of the postflight period. In this connection, all conclusions, as to metabolism peculiarities during the space flight, were to a large extent probabilistic. The purpose of this work was study of metabolism characteristics in cosmonauts directly during long-term space flights. In the capillary blood samples taken from a finger, by "Reflotron IV" biochemical analyzer, "Boehringer Mannheim" GmbH, Germany, adapted to weightlessness environments, the activity of GOT, GPT, CK, gamma-GT, total and pancreatic amylase, as well as concentration of hemoglobin, glucose, total bilirubin, uric acid, urea, creatinine, total, HDL- and LDL cholesterol, triglycerides had been determined. HDL/LDL-cholesterol ratio also was computed. The crewmembers of 6 main missions to the "Mir" orbital station, a total of 17 cosmonauts, were examined. Biochemical tests were carried out 30-60 days before launch, and in the flights different stages between the 25-th and the 423-rd days of flights. In cosmonauts during space flight had been found tendency to increase, in compare with basal level, GOT, GPT, total amylase activity, glucose and total cholesterol concentration, and tendency to decrease of CK activity, hemoglobin, HDL-cholesterol concentration, and HDL/LDL - cholesterol ratio. Some definite trends in variations of other determined biochemical parameters had not been found. The same trends of mentioned biochemical parameters alterations observed in majority of tested cosmonauts, allows to suppose existence of connection between noted metabolic alterations with influence of space flight conditions upon cosmonaut's body. Variations of other studied blood biochemical parameters depends on, probably, pure individual causes.     

Application of the mechanical oscillator technique to the investigation of EVA decompression

The ultrasonic bubble detection technique has been used as a versatile tool in the investigation of hypobaric decompression procedures for the last two decades. However, this method can only detect relatively large bubbles > 30-50 micrometers (usually in venous blood) and not the very first stages of bubble formation. Recently, the mechanical oscillator technique has been applied in air diving trials in order to detect small blood density changes due to hypothetical fluid shifts. However, sharp density drops were found in the decompression process, and these have been attributed to gas bubble formation. In this study, this method was applied together with Doppler controls to a series of altitude decompressions to 300 and 500 hPa, which represents the range of EVA operational pressures currently used or planned. Six subjects participated in both series; the oscillator sample tube could be pressurized. By the application of pressure on a blood sample containing questionable gas bubbles, these are reduced in volume, like in recompression therapy, and thus the density of the sample is increased. This effect has been shown in all 6 subjects undergoing decompression to 300 hPa, whereas in the 500 hPa series only 3 out of 6 subjects corresponded with gas phase formation immediately after decompression. Typically, Doppler bubbles appeared only after some latency time between 20 and 60 min; after this time, the density effect had nearly vanished. It is concluded that the mechanical oscillator technique represents a complementary research instrument to the Doppler method, because it is able to deliver a quantitative resolution of the early stage of gas phase formation.     

CASH 2021: commercial access and space habitation

Issues about commercialization of space have been a growing concern in the past decade for the space community. This paper focuses on the work from a team of 51 students attending the Summer Session Program of the International Space University in Bremen, Germany. CASH 2021 (Commercial Access and Space Habitation) documents a plan that identifies commercial opportunities for space utilization that will extend human presence in space, and will chart the way forward for the next 20 years. The group selected four commercial sectors that show the most promise for the future: tourism, entertainment, space system service, assembly and debris removal, and research and development/production. The content of this document presents the results of their research. Historical activities in each of the commercial sectors are reviewed along with the current market situation. To provide a coherent background for future commercialization possibilities a scenario has been developed. This scenario includes a postulated upon ideal future and includes social, political and economic factors that may affect the space industry over the timeline of the study. The study also presents a roadmap, within the limited optimistic scenario developed, for the successful commercialization of space leading to future human presence in space. A broad range of commercially viable opportunities, not only within the current limits of the International Space Station, but also among the many new developments that are expected by 2021 are discussed.     

Results of space experiment program "Interferon"

The results of the biological space experiment "Interferon" performed by two international cosmonaut teams (26 May 1980, and 16 May 1981) aboard space laboratory Solyut-6 are reported: (1) Human lymphocytes separated from blood of healthy donors and placed into "Interferon I" equipment could be kept for 7 days in suspension culture under spaceflight conditions. Interferon production could be induced in human lymphocytes by preparations of different origin: virus, synthetic polyribonucleotides, bacterial protein and plant pigment. An increased lymphocyte interferon production in space laboratory compared to ground control was observed. (2) Human interferon preparations and interferon inducers placed in space laboratory at room temperature for 7 days maintained their biological activity. (3) A decrease of induced interferon production and natural killer activity of lymphocytes isolated from peripheral blood of cosmonauts was observed on the 1st day on Earth after 7-days spaceflight.     

Spatial factors and muscle spindle input influence the generation of neuromuscular responses to stimulation of the human foot

Removal of the mechanical pressure gradient on the soles leads to physiological adaptations that ultimately result in neuromotor degradation during spaceflight. We propose that mechanical stimulation of the soles serves to partially restore the afference associated with bipedal loading and assists in attenuating the negative neuromotor consequences of spaceflight. A dynamic foot stimulus device was used to stimulate the soles in a variety of conditions with different stimulation locations, stimulation patterns and muscle spindle input. Surface electromyography revealed the lateral side of the sole elicited the greatest neuromuscular response in ankle musculature, followed by the medial side, then the heel. These responses were modified by preceding stimulation. Neuromuscular responses were also influenced by the level of muscle spindle input. These results provide important information that can be used to guide the development of a “passive” countermeasure that relies on sole stimulation and can supplement existing exercise protocols during spaceflight.     

Precision bone and muscle loss measurements by advanced, multiple projection DEXA (AMPDXA) techniques for spaceflight applications.

An advanced, multiple projection, dual energy x-ray absorptiometry (AMPDXA) scanner system is under development. The AMPDXA is designed to make precision bone and muscle loss measurements necessary to determine the deleterious effects of microgravity on astronauts as well as develop countermeasures to stem their bone and muscle loss. To date, a full size test system has been developed to verify principles and the results of computer simulations. Results indicate that accurate predictions of bone mechanical properties can be determined from as few as three projections, while more projections are needed for a complete, three-dimensional reconstruction.     

Envelope Threshold Detection in a Class of Non-Gaussian Interference

This paper considers the detection of a sinusoidal or chirp signal imbedded in wideband FM interference (as might be generated by some types of active jamming), such that after pulse compression or other integration, the interference can be approximated by a sum of sinusoids of independent phase. The detection probability in such non-Gaussian noise is compared to that for Gaussian noise, with the Gaussian result approached, as required, in the limit that the number of sinusoids in the sum increases without bound. For detection using a comparison of the envelope with a threshold which yields a given false-alarm probability (CFAR detection), the detection probability is improved over the case of Gaussian noise, so that the usual approach basing the design on Gaussian noise would be conservative. Using a threshold determined from the envelope mean, the FM interference yields a lower false-alarm probability than for Gaussian noise, with detection probability only slightly degraded.     

Application of the Concept of Referenced Radio Navigation

This paper discusses referenced radio navigation, the concept whereby monitoring stations at known locations are used to calibrate out systematic errors in a navigation system. This concept is implemented by broadcasting calibration data to the navigating user for application as real-time corrections to the position fixes made by the user's basic navigation equipment. A method is suggested for the automatic transmission and receiver processing of the correction data. Referenced radio navigation overcomes many of the shortcomings generally associated with long-distance navigation systems, and can increase accuracy and repeatability significantly. The concept is particularly applicable to global navigation systems such as OMEGA, in which propagation or synchronization errors can contribute substantially to the system error budget.     

Detection of Known Signals in Nonstationary Noise

The basic design of a nonlinear, time-invariant filter is postulated for detecting signal pulses of known shape imbedded in nonstationary noise. The noise is a sample function of a Gaussian random process whose statistics are approximately constant during the length of a signal pulse. The parameters of the filter are optimized to maximize the output signal-to-noise ratio (SNR). The resulting nonlinear filter has the interesting property of approximating the performance of an adaptive filter in that it weights each frequency band of each input pulse by a factor that depends on the instantaneous noise power spectrum present at that time. The SNR at the output of the nonlinear filter is compared to that at the output of a matched filter. The relative performance of the nonlinear system is good when the signal pulses have large time-bandwidth products and the instantaneous noise power spectrum is colored in the signal pass band.