Neoplastic transformation of hamster embryo cells by heavy ions

We have studied the induction of morphological transformation of Syrian hamster embryo cells by low doses of heavy ions with different linear energy transfer (LET), ranging from 13 to 400 keV/μm. Exponentially growing cells were irradiated with ¹²C or ²⁸Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), inoculated to culture dishes, and transformed colonies were identified when the cells were densely stacked and showed a crisscross pattern. Over the LET range examined, the frequency of transformation induced by the heavy ions increased sharply at very low doses no greater than 5 cGy. The relative biological effectiveness (RBE) of the heavy ions relative to 250 kVp X-rays showed an initial increase with LET, reaching a maximum value of about 7 at 100 keV/μm, and then decreased with the further increase in LET. Thus, we confirmed that high LET heavy ions are significantly more effective than X-rays for the induction of in vitro cell transformation.     

On the Velocity and Intensity Asymmetries of Solar P-Mode Lines

We show that to explain the opposite line asymmetries shown by the velocity and intensity spectra, it is necessary to solve the full non-adiabatic problem which is at least of the fourth order. This revised version was published online in June 2006 with corrections to the Cover Date.     

Variations of ionospheric fluctuations of phase delay depending on solar activity: Data of the COSMIC experiment

We present the results of processing and analysis of more than 4500 events of radio occultation sounding of the Earth’s atmosphere observed in the course of the COSMIC experiment on the limb path ‘satellite-ionosphere-satellite’. Events observed in December 2011 (when a number of solar flares occurred) and in January 2012 (when a strong solar proton event took place) were analyzed. It is shown that small-scale variations of electron density increase in polar latitudes, equatorial region, and midlatitudes of the southern hemisphere in January 2012. In the same period, an increase of large-scale variations of electron density is observed during daylight hours in the equatorial region and in the southern hemisphere. No noticeable distinctions in comparison with days of quiet Sun were observed in December 2011.     

Repair of DNA double-strand breaks and cell killing by charged particles.

It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS.     

Numerical prediction and wind tunnel experiment for a pitching unmanned combat air vehicle

The low-speed flowfield for a generic unmanned combat air vehicle (UCAV) is investigated both experimentally and numerically. A wind tunnel experiment was conducted with the Boeing 1301 UCAV at a variety of angles of attack up to 70 degrees, both statically and with various frequencies of pitch oscillation (0.5, 1.0, and 2.0 Hz). In addition, pitching was performed about three longitudinal locations on the configuration (the nose, 35% MAC, and the tail). Solutions to the unsteady, laminar, compressible Navier–Stokes equations were obtained on an unstructured mesh to match results from the static and dynamic experiments. The computational results are compared with experimental results for both static and pitching cases. Details about the flowfield, including vortex formation and interaction, are shown and discussed, including the non-linear aerodynamic characteristics of the vehicle.     

Adaptive detection schemes in compound-Gaussian clutter

Radar detection of coherent pulse trains embedded in compound-Gaussian disturbance with partially known statistics is discussed. We first give a thorough derivation of two recently proposed adaptive detection structures. Next, we derive a different detection scheme exploiting the assumption that the clutter is wide-sense stationary. Resorting to the theory of circulant matrices, in fact, we demonstrate that the estimation of the structure of the clutter covariance matrix can be reduced to the estimation of its eigenvalues, which in turn can be (efficiently) done via fast Fourier transform codes. After a thorough performance assessment, mostly carried on via computer simulations, the results show that the newly proposed detector achieves better performance than the two previously introduced adaptive detectors. Moreover, a sensitivity analysis shows that, even though this detector does not strictly guarantee the constant false alarm rate property with respect to the clutter covariance matrix, it is robust, in the sense that its performance is only slightly affected by variations in the clutter temporal correlation     

Empirical modeling of the total electron content in the ionosphere

A method of modeling the total electron content (TEC) based on the semi-empirical ionospheric model developed in Irkutsk State University is suggested. Comparison with the Klobuchar model has shown that the proposed method provides a more accurate presentation of TEC. A conclusion is drawn that the use of this method for compensation of the ionospheric error in single-frequency navigation receivers would lead to a substantial increase in the accuracy of their positioning.     

PowerCore combining structure and batteries for increased energy toweight ratio

Much of the mass of a battery is comprised of nonreactive materials. In an NiH₂ battery, this includes the pressure vessel and 50% of the positive electrode. PowerCore reconfigures the battery materials to serve as a structural sandwich panel. The effective specific energy of the new device can exceed 100 Wh/kg. PowerCore is intended to handle power demands of low Earth orbiting communications satellites such as IRIDIUM. This paper describes the concept and development progress     

Maps of hydrogen isotopes at low altitudes in the inner zone from sampex observations

The PET instrument aboard the SAMPEX satellite has provided us with long-term intra-calibrated observations of geomagnetically trapped protons and deuterons in the inner zone, suitable for use in constraining the low-altitude portions of radiation belt models being developed as successors to AP-8. These observations have been summarized elsewhere (Looper et al., 1996). Here we report a detection of geomagnetically-trapped tritium at energies from 14 to 35 MeV/nuc below L = 1.2, at about 1/8 the flux of deuterium previously reported at that location and at similar energy per nucleon. We also demonstrate the utility of the SAMPEX/PET observations for measuring the east-west anisotropy in the trapped particle flux at low altitudes, which is due to displacement of particle gyrocenters from the position of observation in a region of strong flux gradients. This anisotropy is implicitly ignored in omnidirectional radiation-flux models, but it can be important to mission planners considering how to distribute shielding over the surface of oriented spacecraft in low Earth orbit.     

New evidence for strong non-thermal effects in Tycho’s supernova remnant

For the case of Tycho’s supernova remnant (SNR), we present the relation between the blast wave and contact discontinuity radii calculated within the nonlinear kinetic theory of cosmic ray (CR) acceleration in SNRs. It is demonstrated that these radii are confirmed by recently published Chandra measurements which show that the observed contact discontinuity radius is very close to the shock radius. Therefore a consistent explanation of these observations can be given in terms of efficient CR acceleration which makes the medium more compressible.