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Li-xue Zou Shao-yan CuiJian Zhong Zong-chun YiYan Sun Yu-bo FanFeng-yuan Zhuang 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2010
Hematopoietic progenitor cell proliferation can be alternated on either spaceflight or under simulated microgravity experiments on the ground; however, the underlying mechanism remains largely unknown. In the present study, we have demonstrated that exposure of human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO cells to conditions of simulated microgravity with a rotary culture instrument significantly inhibited the cellular proliferation rate. Adding higher concentrations of EPO to the culture medium failed to improve the inhibitory status. Cell apoptosis was detected by fluorescence staining of cell nuclei and a flow cytometry assay using Annexin V/PI double staining. This microgravity-induced apoptosis in UT-7/EPO cells could be blocked by a pancaspase inhibitor Z-VAD-FMK. Immunoblotting demonstrated that rotary culture resulted in a reduction of the expression of Bcl-xL, an anti-apoptotic protein, and the cleavage of caspase-3. Furthermore, rotary culture reduced surface localization and protein content, as well as the mRNA expression of erythropoietin receptor (EPOR) of UT-7/EPO. Take together, the findings indicated that simulated microgravity may induce mitochondrial related apoptosis of UT-7/EPO cell through depressing the EPO–EPOR pathway. 相似文献
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数字化人体建模技术--Pro/Engimeer Mankin 近日,PTC公司推出的Pro/Engineer Mankin是一款能够使设计团队在3D产品的设计模型中插入3D数字化人体造模解决方案,用以模拟仿真及实现人机互动. 相似文献
74.
Li-xue Zou Shao-yan CuiJian Zhong Zong-chun YiYan Sun Yu-bo FanFeng-yuan Zhuang 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2011
Hematopoietic progenitor cell proliferation can be altered in either spaceflight or under simulated microgravity experiments on the ground, however, the underlying mechanism remains unknown. Our previous study showed that exposure of the human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO to conditions of simulated microgravity significantly inhibited the cellular proliferation rate and induced cell apoptosis. We postulated that the downregulation of the erythropoietin receptor (EPOR) expression in UT-7/EPO cells under simulated microgravity may be a possible reason for microgravity triggered apoptosis. In this paper, a human EPOR gene was transferred into UT-7/EPO cells and the resulting expression of EPOR on the surface of UT-7/EPO cells increased approximately 61% (p < 0.05) as selected by the antibiotic G418. It was also shown through cytometry assays and morphological observations that microgravity-induced apoptosis markedly decreased in these UT-7/EPO–EPOR cells. Thus, we concluded that upregulation of EPOR in UT-7/EPO cells could inhibit the simulated microgravity-induced cell apoptosis in this EPO dependent cell line. 相似文献
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行进了可压缩球涡和平面激波相互作用的数值研究。一方面,用非定常Euler方程数值模拟了一种可压缩球涡的自身演化,同时,利用Rankine-Hugoniot关系,在流场中嵌入运动激波,求解了激波-球涡相干的流动过程。 相似文献
76.
研制了三种急冷Al基活性钎料。研究结果表明:急冷Al基活性钎料的组织明显细化,熔点明显下降,基体硬度升高。在较低的钎焊温度(750℃)下,下加Ni粉的接头的剪切强度较高(208.8MPa)。钎焊温度对接头强度影响较大。当超过一定钎焊温度后,接头强度明显下降;加Ni粉复合钎焊可明显提高接头的剪切强度,在钎焊温度为800℃时接头的最高剪切强度为225MPa,加Ni粉的复合接头在界面两侧形成均匀分布富Ni带。这是接头强度提高的主要原因。 相似文献
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描述了一种可移动式铯原子钟的设计和性能。该装置可断续或连续运行,结构独特、潜力较大,在一定使用环境下,主要技术指标达到了国外商品铯钟相应的先进水平。 相似文献