Normalized ionization yield function for various nuclei obtained with full Monte Carlo simulations

Several recent results important for production of ion pairs in the Earth atmosphere by various primary cosmic ray nuclei are presented. The direct ionization by various primary cosmic ray nuclei is explicitly obtained. The longitudinal profile of atmospheric cascades is sensitive to the energy and mass (charge) of the primary particle. In this study different cosmic ray nuclei are considered as primaries, namely Helium, Oxygen and Iron nuclei. The cosmic ray induced ionization is obtained on the basis of CORSIKA 6.52 code simulations using FLUKA 2006 and QGSJET II hadronic interaction models. The energy of the primary particles is normalized to GeV per nucleon. In addition, the ionization yield function Y is normalized as ion pair production per nucleon. The obtained ionization yield functions Y for various primaries are compared. The presented results and their application are discussed.     

Subcritical and supercritical water oxidation of CELSS model wastes.

Controlled-Ecological-Life-Support-System (CELSS) model wastes were wet-oxidized at temperatures from 250 to 500 degrees C, i.e., below and above the critical point of water (374 degrees C and 218 kg/cm2 or 21.4 MPa). A solution of ammonium hydroxide and acetic acid and a slurry of human urine, feces, and wipes were used as model wastes. Almost all of the organic matter in the model wastes was oxidized in the temperature range from 400 to 500 degrees C, i.e., above the critical conditions for water. In contrast, only a small portion of the organic matter was oxidized at subcritical conditions. Although the extent of nitrogen oxidation to nitrous oxide (N2O) and/or nitrogen gas (N2) increased with reaction temperature, most of the nitrogen was retained in solution as ammonia near 400 degrees C. This important finding suggests that most of the nitrogen in the waste feed can be retained in solution as ammonia during oxidation at low supercritical temperatures and be subsequently used as a nitrogen source for plants in a CELSS while at the same time organic matter is almost completely oxidized to carbon dioxide and water. It was also found in this study the Hastelloy C-276 alloy reactor corroded during waste oxidation. The rate of corrosion was lower above than below the critical temperature for water.     

Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

Adaptive variable structure tracking control for constrained robots

The problem of controller design for constrained robots with the consideration of computational efficiency is addressed. An efficient adaptive variable structure control algorithm based on a reduced dynamics formulation, is presented for trajectory tracking of an end-effector on a constrained surface with specified constraint forces. It is shown that the objective can be achieved without exact knowledge of robot dynamics and on-line calculation of nonlinear dynamic functions. The control algorithm is constructed with at most three control parameters to be adjusted adaptively, and that number is determined independently of the number of degrees of freedom of the robotic manipulators. A numerical example is presented to illustrate the developed method     

Third-Order Loop Filter Design for Acceleration-Rate Tracking

A perfect third-order loop filter design that can be implemented as a digital filter is obtained which minimizes the noiseless steady-state acceleration rate (jerk) error for a fixed loop noise bandwidth. Simulations were performed to obtain transient responses of the third-order loop plus a sample fourth-order loop under a jerk input. The results enable one to obtain a loop design that minimizes the loop noise bandwidth required for a given steady-state jerk error and thus obtain better noise jitter performance.     

GNSS超快速产品在全球标准时间复现中的应用

为满足大跨度空间范围内的时间同步需求,对基于共视时间比对原理的标准时间复现系统进行改进,采用全视时间比对方法解决原系统应用基线受限的问题。考虑实时性的要求,使用全球卫星导航系统(GNSS)超快速产品(预测部分)提供卫星位置和卫星钟差,以尽可能消除广播星历和钟差对复现结果的影响。分析了常用的几家机构发布的GNSS超快速产品,并且结合复现系统的具体应用场景要求,研究了GNSS超快速产品的选择、下载和使用方法,以及使用时需要注意的关键问题,包括产品文件的更换以及产品的时间参考基准对标准时间复现的影响。     

基于CFD技术的鼻腔输药的流动特性研究

鼻腔输药作为一种新颖的输药方式,具有方便可靠的特点,不仅可以适用于局部而且适用于全身用药,已经受到广泛的重视。但由于人类的呼吸道复杂的立体结构使得鼻腔输药成为生物医药研究的一个长期的挑战。利用CFD(计算流体动力学,Computational Fluid Dynamics)技术对鼻腔输药的流动特性进行研究,对一个基于真实的人类鼻腔解剖的3D模型的输药的流动过程进行了分析,着重研究了不同的药物颗粒的流动和沉淀特性。利用CFD的商用软件FLUENT在层流情况下对不同的密度、直径和流动速率的药物颗粒在鼻腔中流动进行了数值模拟,并对计算结果进行了比较分析。CFD研究的结果为鼻腔输药这种新颖的药物输送方式的优化设计提供了依据。     

Global Response of Martian Plasma Environment to an Interplanetary Structure: From Ena and Plasma Observations at Mars

As a part of the global plasma environment study of Mars and its response to the solar wind, we have analyzed a peculiar case of the subsolar energetic neutral atom (ENA) jet observed on June 7, 2004 by the Neutral Particle Detector (NPD) on board the Mars Express satellite. The “subsolar ENA jet” is generated by the interaction between the solar wind and the Martian exosphere, and is one of the most intense sources of ENA flux observed in the vicinity of Mars. On June 7, 2004 (orbit 485 of Mars Express), the NPD observed a very intense subsolar ENA jet, which then abruptly decreased within ∼10 sec followed by quasi-periodic (∼1 min) flux variations. Simultaneously, the plasma sensors detected a solar wind structure, which was most likely an interplanetary shock surface. The abrupt decrease of the ENA flux and the quasi-periodic flux variations can be understood in the framework of the global response of the Martian plasma obstacle to the interplanetary shock. The generation region of the subsolar ENA jet was pushed towards the planet by the interplanetary shock; and therefore, Mars Express went out of the ENA jet region. Associated global vibrations of the Martian plasma obstacle may have been the cause of the quasi-periodic flux variations of the ENA flux at the spacecraft location.