基于CFD技术的鼻腔输药的流动特性研究

鼻腔输药作为一种新颖的输药方式,具有方便可靠的特点,不仅可以适用于局部而且适用于全身用药,已经受到广泛的重视。但由于人类的呼吸道复杂的立体结构使得鼻腔输药成为生物医药研究的一个长期的挑战。利用CFD(计算流体动力学,Computational Fluid Dynamics)技术对鼻腔输药的流动特性进行研究,对一个基于真实的人类鼻腔解剖的3D模型的输药的流动过程进行了分析,着重研究了不同的药物颗粒的流动和沉淀特性。利用CFD的商用软件FLUENT在层流情况下对不同的密度、直径和流动速率的药物颗粒在鼻腔中流动进行了数值模拟,并对计算结果进行了比较分析。CFD研究的结果为鼻腔输药这种新颖的药物输送方式的优化设计提供了依据。     

Muscle atrophy associated with microgravity in rat: basic data for countermeasures

Morphological, contractile properties and myosin heavy chain (MHC) composition of rat soleus muscles were studied after 2 weeks of unloading (HS) and after 2 weeks of HS associated with selective deafferentation (HS + DEAF) at the level L4 and L5. The same significant reductions in muscle mass and tetanic tension were found after HS and HS + DEAF. However, the transformation of the slow-twitch soleus muscle towards a faster type characterized by a decrease in twitch time parameters and an increase in fast-twitch type MHC isoforms in HS did not appear in HS + DEAF conditions. Our results also showed that a pattern similar to firing rate of motoneurones innervating slow-twitch muscles inhibited the slow to fast fiber changes observed during HS. Nevertheless, neither the loss of mass or force output in the HS muscles were prevented by electrostimulation. Immobilization in a stretched position during HS maintained the muscle wet weight, mechanical and electrophoretical characteristics close to control values. We concluded that the decrease in mechanical strains imposed on the muscle during unloading was the main factor for the development of atrophy, while the kinetic changes might be predominantly modulated by the nervous command. These basic data suggested that some experimental conditions such as electrostimulation or stretching, could participate in countermeasure programmes.     

昆虫翅悬停飞行中的三维空间旋涡结构

昆虫(果蝇)悬停飞行中,翅膀按照特定的拍动方式往复运动,产生非定常高升力维持身体的平衡.研究昆虫高升力机理,需要探索拍动翼运动引发的三维空间非定常流场的特性,尤其是三维空间非定常涡的发展变化过程.本文将氢气泡流动显示技术应用于动态模型实验,定性的观察拍动翼前缘涡(LEV)的发展破裂过程.并利用数字体视粒子图像测速,DSPIV(Digital Steroscopic Particle Image Velocimetry)技术,测得了拍动翼运动瞬时相位和相位平均的三维空间流场信息(速度向量场、截面涡量场、空间涡量场,以及三维空间流线),揭示了拍动翼展向流动的存在,并结合定性和定量方法多角度说明了前缘涡沿展向发展到破裂的流动结构,并说明了侧缘涡与前缘涡的相互影响.测量结果表明:在雷诺数960的情况下,拍动翼运动至相位时,翼面上前缘涡在距翼根约60%展长的位置发生破裂;翼根至破裂点之间,展向流动稳定,指向翼梢;破裂点以后,展向流改变方向,指向翼根.     

Controlling factors of Region 2 field-aligned current and its relationship to the ring current: Model results

One essential component of magnetosphere and ionosphere coupling is the closure of the ring current through Region 2 field-aligned current (FAC). Using the Comprehensive Ring Current Model (CRCM), which includes magnetosphere and ionosphere coupling by solving the kinetic equation of ring current particles and the closure of the electric currents between the two regions, we have investigated the effects of high latitude potential, ionospheric conductivity, plasma sheet density and different magnetic field models on the development of Region 2 field-aligned currents, and the relationship between R2 FACs and the ring current. It is shown that an increase in high latitude potential, ionospheric conductivity or plasma sheet density generally results in an increase in Region 2 FACs’ intensity, but R2 FACs display different local time and latitudinal distributions for changes in each parameter due to the different mechanisms involved. Our simulation results show that the magnetic field configuration of the inner magnetosphere is also an important factor in the development of Region 2 field-aligned current. More numerical experiments and observational results are needed in further our understanding of the complex relationship of the two current systems.     

GNSS超快速产品在全球标准时间复现中的应用

为满足大跨度空间范围内的时间同步需求,对基于共视时间比对原理的标准时间复现系统进行改进,采用全视时间比对方法解决原系统应用基线受限的问题。考虑实时性的要求,使用全球卫星导航系统(GNSS)超快速产品(预测部分)提供卫星位置和卫星钟差,以尽可能消除广播星历和钟差对复现结果的影响。分析了常用的几家机构发布的GNSS超快速产品,并且结合复现系统的具体应用场景要求,研究了GNSS超快速产品的选择、下载和使用方法,以及使用时需要注意的关键问题,包括产品文件的更换以及产品的时间参考基准对标准时间复现的影响。     

High-Order Intermodulation Effects in Digital Satellite Channels

The phenomenon of intermodulation generation due to passive and normally linear components is sometimes called passive intermodulation. A unique characteristic of passive intermodulation interference in communications satellites is that the products causing trouble are of high orders. Due to the immense combinatorial complexity of the problem, both exact analysis and direct simulation are almost impossible. In this paper the problem is simplified by considering a composite interference model consisting of 1) the lowest order intermodulation product (of those high-order ones) at a frequency of interest, 2) a constant-envelope carrier with random phase to account for all other intermodulation interferences by direct overlap or spectrum spreading in the vicinity, and 3) white Gaussian noise (receiver noise). An approximation of the tail statistics of this composite interference is derived, and numerical results (checked by simulation) show that the tail distribution may be very different from Gaussian; careful consideration must be rendered before resorting to the a priori Gaussian assumption.     

Exact multisensor dynamic bias estimation with local tracks

An exact solution is provided for the multiple sensor bias estimation problem based on local tracks. It is shown that the sensor bias estimates can be obtained dynamically using the outputs of the local (biased) state estimators. This is accomplished by manipulating the local state estimates such that they yield pseudomeasurements of the sensor biases with additive noises that are zero-mean, white, and with easily calculated covariances. These results allow evaluation of the Cramer-Rao lower bound (CRLB) on the covariance of the sensor bias estimates, i.e., a quantification of the available information about the sensor biases in any scenario. Monte Carlo simulations show that this method has significant improvement in performance with reduced rms errors of 70% compared with commonly used decoupled Kalman filter. Furthermore, the new method is shown to be statistically efficient, i.e., it meets the CRLB. The extension of the new technique for dynamically varying sensor biases is also presented.     

军用飞机使用维护危险分析方法研究

提出一种军用飞机使用维护危险分析方法,支撑国内军用飞机研制过程中安全性设计相关工作的开展。梳理使用维护危险分析与安全性、保障性其他分析工作的关系,明确使用维护危险分析工作输入、输出信息,以及工作界面。基于军用飞机使用维护作业特点,从\"人-机-环境\"的角度开展使用维护安全影响因素分析,识别军机使用维护作业过程中潜在的危险因素,及对于使用维护作业安全的影响。建立一种使用维护危险分析工具,并引入发生概率和严重性结合的安全性评价标准,提出使用维护风险评价方法,完善军用飞机使用维护危险分析评估体系。