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801.
Dose protraction studies with low- and high-LET radiations on neoplastic cell transformation in vitro. 总被引:1,自引:0,他引:1
L M Yang TC-HCraise C A Mei M-TTobias 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1986,6(11):137-147
A major objective of our heavy-ion research is to understand the potential carcinogenic effects of cosmic rays and the mechanisms of radiation-induced cell transformation. During the past several years, we have studied the relative biological effectiveness of heavy ions with various atomic numbers and linear energy transfer on neoplastic cell transformation and the repair of transformation lesions induced by heavy ions in mammalian cells. All of these studies, however, were done with a high dose rate. For risk assessment, it is extremely important to have data on the low-dose-rate effect of heavy ions. Recently, with confluent cultures of the C3H10T1/2 cell line, we have initiated some studies on the low-dose-rate effect of low- and high-LET radiation on cell transformation. For low-LET photons, there was a decrease in cell killing and cell transformation frequency when cells were irradiated with fractionated doses and at low dose rate. Cultured mammalian cells can repair both subtransformation and potential transformation lesions induced by X rays. The kinetics of potential transformation damage repair is a slow one. No sparing effect, however, was found for high-LET radiation. There was an enhancement of cell transformation for low-dose-rate argon (400 MeV/u; 120 keV/micrometer) and iron particles (600 MeV/u; 200 keV/micrometer). The molecular mechanisms for the enhancement effect is unknown at present. 相似文献
802.
P Bouisset V D Nguyen Y A Akatov M Siegrist N Parmentier V V Archangelsky A S Vorojtsov V M Petrov E E Kovalev 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1992,12(2-3):363-367
Since Dec 1988, date of the French-Soviet joint space mission "ARAGATZ", the CIRCE device (Compteur Intégrateur de Rayonnement Complexe dans l'Espace) had recorded dose equivalent and quality factor inside the MIR station (380-410 km, 51.5 degrees). After the initial gas filling two years ago, the low pressure tissue equivalent proportional counter is still in good working conditions. Some results of three periods, viz Dec 1988, Mar-Apr 1989 and Jan-Feb 1990 are presented. The average dose equivalent rates measured are respectively 0.6, 0.8 and 0.6 mSv/day with a quality factor equal to 1.9. Some detailed measurements show the increasing of the dose equivalent rates through the SAA and near polar horns. The real time determination of the quality factors allows to point out high LET (Linear Energy Transfer) events with quality factors in the range 10-20. 相似文献
803.
Y. I. Feldstein 《Space Science Reviews》1992,59(1-2):83-165
The models are examined which are proposed elsewhere for describing the magnetic field dynamics in ring-currentDR during magnetic storms on the basis of the magnetospheric energy balance equation. The equation parameters, the functions of injectionF and decay , are assumed to depend on interplanetary medium parameters (F and during the storm main phase) and on ring-current intensity ( during the recovery phase). The present-day models are shown to be able of describing theDR variations to within a good accuracy (the r.m.s. deviation 5 < < 15 nT, the correlation coefficient 0.85 <r < 1). The models describe a fraction of the geomagnetic field variation during a magnetic storm controlled by the geoeffective characteristic of interplanetary medium and, therefore responds directly to the variation of the latter. The fraction forms the basis of the geomagnetic field variations in low and middle latitudes. The shorter-term variations ofDR are affected by the injections into the inner magnetosphere during substorm intervals.During magnetic storms, the auroral electrojets shift to subauroral latitudes. When determining theAE indices, the data from the auroral-zone stations must be supplemented with the data from subauroral observatories. Otherwise, erratic conclusions may be obtained concerning the character of the relationships ofDR toAE or ofAE to interplanetary medium parameters. Considering this circumstance, the auroral electrojet intensity during the main phase is closely related to the energy flux supplied to the ring current. It is this fact that gives rise simultaneously to the intensification of auroral electrojets and to the large-scale decrease of magnetic field in low latitudes.The longitudinal asymmetry of magnetic field on the Earth's surface is closely associated with the geoeffective parameters of interplanetary medium, thereby making it possible to model-estimate the magnetic field variations during magnetic storms at given observatories. The inclusion of the field asymmetry due to the system of large-scale currents improves significantly the agreement between the predicted and model field variations at subauroral and midlatitude observatories. The first harmonic amplitude of field variation increases with decreasing latitude. This means that the long-period component of theD
st
-variation asymmetry is due rather to the ring-current asymmetry, while the shorter-term fluctuations are produced by electrojets. The asymmetry correlates better with theAL indices (westward electrojet) than with theAU indices (eastward electrojet).The total ion energy in the inner magnetosphere during the storm main phase is sufficient for the magnetic field observed on the Earth's surface to be generated. The energy flux to the ring current is 15% of the -energy flux into the magnetosphere. 相似文献
804.
The aim of this study was to evaluate the effect of different body positions on renal excretion of fluid and electrolytes after exposure to 364 days of decreased number of steps per day (hypokinesia, HK). The studies were performed on 18 endurance trained male volunteers aged 19-24 years who had an average of VO2max 67 ml/kg body/min. All volunteers were divided into three equal groups: the 1st group subjected to 12 h orthostatic position (OP) and 12 h clinostatic position (CP)/day, the 2nd group exposed to 8 h orthostatic position and 14 h clinostatic position/day, and the 3rd group submitted to 10 h orthostatic position and 16 h clinostatic position/day for 364 days. For the simulation of the hypokinetic effect all volunteers were kept under an average of 3000 steps/day for 364 days. Diuresis and the concentrations of sodium, potassium, chloride, calcium and magnesium as well as excretion of creatine were determined in 24-h urine samples. By the end of the hypokinetic period all volunteers, regardless of their body position during HK, manifested a significant increase in renal excretion of fluid and electrolytes as compared to prehypokinetic period values. It was concluded that prolonged restriction of motor activity induced a significant increase in renal excretion of fluid and electrolytes in endurance trained subjects regardless to their body position and duration thereof per day. 相似文献
805.
S. A. Baba Y. Mogami T. Otsu 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1999,23(12):2065
It is still debated whether or not gravity can stimulate unicellular organisms. This question may be settled by revealing changes in the membrane potential in a manner depending on the gravitational forces imposed on the cell. We estimated the gravity-dependent membrane potential shift to be about 1 mV G−1 for Paramecium showing gravikinesis at 1–5 G, on the basis of measurements of gravity-induced changes in active propulsion and those of propulsive velocity in solutions, in which the membrane potential has been measured electrophysiologically. The shift in membrane potential to this extent may occur from mechanoreceptive changes in K+ or Ca2+ conductance by about 1% and might be at the limit of electrophysiological measurement using membrane potential-sensitive dyes. Our measurements of propulsive velocity vs membrane potential also suggested that the reported propulsive force of Paramecium measured in a solution of graded densities with the aid of a video centrifuge microscope at 350 G was 11 times as large as that for −29 mV, i.e., the resting membrane potential at [K+]o = 1 mM and [Ca2+]o = 1 mM, and, by extrapolation, that Paramecium was hyperpolarized to −60 mV by gravity stimulation of 100- G equivalent, the value corrected by considering the reduction of density difference between the interior and exterior of the cell in the graded density solution. The estimated shift of the membrane potential from −29 mV to −60 mV by 100- G equivalent stimulation, i.e., 0.3 mV G−1, could reach the magnitude entirely feasible to be measured more directly. 相似文献
806.
So H.C. Chan Y.T. Ma Q. Ching P.C. 《IEEE transactions on aerospace and electronic systems》1999,35(3):945-952
With the advent of the fast Fourier transform (FFT) algorithm, the periodogram and its variants such as the Bartlett's procedure and Welch method, have become very popular for spectral analysis. However, there has not been a thorough comparison of the detection and estimation performances of these methods. Different forms of the periodogram are studied here for single real tone detection and frequency estimation in the presence of white Gaussian noise. The threshold effect in frequency estimation, that is, when the estimation errors become several orders of magnitude greater than the Cramer-Rao lower bound (CRLB), is also investigated. It is shown that the standard periodogram gives the optimum detection performance for a pure tone while the Welch method is the best detector when there is phase instability in the sinusoid. As expected, since the conventional periodogram is a maximum likelihood estimator of frequency, it generally provides the minimum mean square frequency estimation errors 相似文献
807.
Popp R.L. Pattipati K.R. Bar-Shalom Y. 《IEEE transactions on aerospace and electronic systems》1999,35(4):1145-1160
In recent years, there has been considerable interest within the tracking community in an approach to data association based on the m-best two-dimensional (2D) assignment algorithm. Much of the interest has been spurred by its ability to provide various efficient data association solutions, including joint probabilistic data association (JPDA) and multiple hypothesis tracking (MHT). The focus of this work is to describe several recent improvements to the m-best 2D assignment algorithm. One improvement is to utilize a nonintrusive 2D assignment algorithm switching mechanism, based on a problem sparsity threshold. Dynamic switching between two different 2D assignment algorithms, highly suited for sparse and dense problems, respectively, enables more efficient solutions to the numerous 2D assignment problems generated in the m-best 2D assignment framework. Another improvement is to utilize a multilevel parallelization enabling many independent and highly parallelizable tasks to be executed concurrently, including 1) solving the multiple 2D assignment problems via a parallelization of the m-best partitioning task, and 2) calculating the numerous gating tests, state estimates, covariance calculations, and likelihood function evaluations (used as cost coefficients in the 2D assignment problem) via a parallelization of the data association interface task. Using both simulated data and an air traffic surveillance (ATS) problem based on data from two Federal Aviation Administration (FAA) air traffic control radars, we demonstrate that efficient solutions to the data association problem are obtainable using our improvements in the m-best 2D assignment algorithm 相似文献
808.
A. Balogh V. Bothmer N.U. Crooker R.J. Forsyth G. Gloeckler A. Hewish M. Hilchenbach R. Kallenbach B. Klecker J.A. Linker E. Lucek G. Mann E. Marsch A. Posner I.G. Richardson J.M. Schmidt M. Scholer Y.-M. Wang R.F. Wimmer-Schweingruber M.R. Aellig P. Bochsler S. Hefti Z. Mikić 《Space Science Reviews》1999,89(1-2):141-178
Corotating Interaction Regions (CIRs) form as a consequence of the compression of the solar wind at the interface between
fast speed streams and slow streams. Dynamic interaction of solar wind streams is a general feature of the heliospheric medium;
when the sources of the solar wind streams are relatively stable, the interaction regions form a pattern which corotates with
the Sun. The regions of origin of the high speed solar wind streams have been clearly identified as the coronal holes with
their open magnetic field structures. The origin of the slow speed solar wind is less clear; slow streams may well originate
from a range of coronal configurations adjacent to, or above magnetically closed structures. This article addresses the coronal
origin of the stable pattern of solar wind streams which leads to the formation of CIRs. In particular, coronal models based
on photospheric measurements are reviewed; we also examine the observations of kinematic and compositional solar wind features
at 1 AU, their appearance in the stream interfaces (SIs) of CIRs, and their relationship to the structure of the solar surface
and the inner corona; finally we summarise the Helios observations in the inner heliosphere of CIRs and their precursors to
give a link between the optical observations on their solar origin and the in-situ plasma observations at 1 AU after their
formation. The most important question that remains to be answered concerning the solar origin of CIRs is related to the origin
and morphology of the slow solar wind.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
809.
H. Kunow M.A. Lee L.A. Fisk R.J. Forsyth B. Heber T.S. Horbury E. Keppler J. Kóta Y.-Q. Lou R.B. McKibben C. Paizis M.S. Potgieter E.C. Roelof T.R. Sanderson G.M. Simnett R. Von Steiger B.T. Tsurutani R.F. Wimmer-Schweingruber J.R. Jokipii 《Space Science Reviews》1999,89(1-2):221-268
Ulysses observed a stable strong CIR from early 1992 through 1994 during its first journey into the southern hemisphere. After
the rapid latitude scan in early 1995, Ulysses observed a weaker CIR from early 1996 to mid-1997 in the northern hemisphere
as it traveled back to the ecliptic at the orbit of Jupiter. These two CIRs are the observational basis of the investigation
into the latitudinal structure of CIRs. The first CIR was caused by an extension of the northern coronal hole into the southern
hemisphere during declining solar activity, whereas the second CIR near solar minimum activity was caused by small warps in
the streamer belt. The latitudinal structure is described through the presentation of three 26-day periods during the southern
CIR. The first at ∼24°S shows the full plasma interaction region including fast and slow wind streams, the compressed shocked
flows with embedded stream interface and heliospheric current sheet (HCS), and the forward and reverse shocks with associated
accelerated ions and electrons. The second at 40°S exhibits only the reverse shock, accelerated particles, and the 26-day
modulation of cosmic rays. The third at 60°S shows only the accelerated particles and modulated cosmic rays. The possible
mechanisms for the access of the accelerated particles and the CIR-modulated cosmic rays to high latitudes above the plasma
interaction region are presented. They include direct magnetic field connection across latitude due to stochastic field line
weaving or to systematic weaving caused by solar differential rotation combined with non-radial expansion of the fast wind.
Another possible mechanism is particle diffusion across the average magnetic field, which includes stochastic field line weaving.
A constraint on connection to a distant portion of the CIR is energy loss in the solar wind, which is substantial for the
relatively slow-moving accelerated ions. Finally, the weaker northern CIR is compared with the southern CIR. It is weak because
the inclination of the streamer belt and HCS decreased as Ulysses traveled to lower latitudes so that the spacecraft remained
at about the maximum latitudinal extent of the HCS.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
810.