多元高温合金固溶极限预测

综合考虑了溶质元素与基体元素的原子半径、电负性以及外层电子数的立方根对溶质元素固溶度的影响，推导出二元合金的固溶度定量方程，提出了多元高温合金固溶极限曲线的预测新方法，并将其应用于计算镍基和钴基三元合金相图的γ／（γ＋σ）相界和γ（γ＋μ）相界。结果表明，计算的固溶极限曲线与已知相图的固溶极限曲线较吻合，与Ｍｄ值法计算的相界比较，该方法具有较高的精度。     

Simulated microgravity induce apoptosis and down-regulation of erythropoietin receptor of UT-7/EPO cells

Hematopoietic progenitor cell proliferation can be alternated on either spaceflight or under simulated microgravity experiments on the ground; however, the underlying mechanism remains largely unknown. In the present study, we have demonstrated that exposure of human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO cells to conditions of simulated microgravity with a rotary culture instrument significantly inhibited the cellular proliferation rate. Adding higher concentrations of EPO to the culture medium failed to improve the inhibitory status. Cell apoptosis was detected by fluorescence staining of cell nuclei and a flow cytometry assay using Annexin V/PI double staining. This microgravity-induced apoptosis in UT-7/EPO cells could be blocked by a pancaspase inhibitor Z-VAD-FMK. Immunoblotting demonstrated that rotary culture resulted in a reduction of the expression of Bcl-xL, an anti-apoptotic protein, and the cleavage of caspase-3. Furthermore, rotary culture reduced surface localization and protein content, as well as the mRNA expression of erythropoietin receptor (EPOR) of UT-7/EPO. Take together, the findings indicated that simulated microgravity may induce mitochondrial related apoptosis of UT-7/EPO cell through depressing the EPO–EPOR pathway.     

细长体大迎角压缩性效应试验分析

采用尖拱细长体模型,在高速风洞中完成了压缩性对大迎角非对称流动影响的试验研究。试验迎角范围为10°～50°,M数范围为0.4～1.2。试验结果表明:压缩性对非对称流动的产生和发展过程不产生本质影响,但影响非对称的强弱和发展速度;当横流Mc0.4时,流动非对称性随M数增加而增加,当Mc0.4时,流动非对称性随M数增加而减弱;Re数和压缩性均对非对称涡流动产生明显影响。     

软件FMEA实例研究

软件FMEA(失效模式和影响分析)是硬件或系统FMEA的扩展,并应用于安全关键软件的鉴定,但是,目前缺乏应用经验。本文阐述了SFMEA的原理、实施过程和要点,提出了适用于某嵌入式软件的失效模式及原因,对失效模式的影响进行了严酷度等级分类,给出了对该软件实施SFMEA的过程和结果。结果表明了SFMEA的有效性和实用性。     

Lunar geophysical parameters inversion based on gravity/topography admittance and particle swarm optimization

This paper presents a FORTRAN computer program. The program as code will be used for lunar parameter inversions based on gravity/topography admittance. This will be done by assuming that the lunar lithosphere is modeled as a thin elastic spherical shell. The parameters discussed here include; load ratio, crustal thickness, subsurface load depth, crustal density and elastic lithosphere thickness. The admittance of the best-fitting model can be found through automatically adjusting misfits between one theoretical admittance and an observed one. The results in this paper indicate that this research’s theoretical model is reasonable for exploring the best-fitting parameters. In addition, this code is not only able to automatically and simultaneously calculate the global optimum solution of the parameters studied, but also performs well in computational speed. The code can be easily modified to include more parameter inversions; such as the inversion for subsurface density anomaly and the case of considering infilling material in some lunar mare basins.     

Enhanced multipath mitigation method based on multi-resolution CNR model and adaptive statistical test strategy for real-time kinematic PPP

This study proposes an enhanced multipath mitigation method based on multi-resolution carrier-to-noise-ratio (CNR) model and adaptive statistical test strategy for real-time kinematic precise point positioning (PPP) applications. The multi-resolution CNR model is established with GPS observation data collected from DOY 152 to 181 of 2019 by 230 globally distributed IGS stations, which used to analyze the relevant factors affecting CNR. Statistical results indicate that the CNR is not only related to the satellite elevation, but also closely related to the receiver types and specific satellite. The maximum difference between different receivers can reach 20 dB for the same satellite at the same elevation. In addition, the performance of the CNR is also obviously different between each satellite, and the maximum difference between different satellites is about 10 dB for the same receiver at the same elevation. Hence, in terms of the method which is based on CNR information for multipath detection and mitigation, the independence of receiver types, satellite and frequency must be considered. With the above analysis, this study developed a multi-resolution CNR model based on different receiver types, different satellites and different elevation firstly. Then, combined with the adaptive statistical test strategy which is based on the difference of CNR between inter-frequency and the difference of CNR between adjacent epochs, the multipath can be detected effectively. For the epoch which affected by multipath, the down-weighted strategy based on CNR is adopted to mitigate the influence of multipath on positioning. Real-time kinematic PPP data are collected to assess the proposed method, and the results demonstrate that the proposed method can detect the multipath effectively, and the detection rate can reach 90.28%. Moreover, after adopting the mitigation strategy, the RMS bias of the east, north and up components are improved about 19.95%, 17.89% and 23.07% compared to the original results, respectively. It is worth noting that this proposed method is also suitable for other GNSS, such as GLONASS and BDS, but the corresponding CNR model must be established simultaneously.     

雷达TR生产线测试系统远程现场整体校准技术研究

针对TR生产线中，用于多品种、小批量产品测试的大型测试系统在质量控制、现场快速、整体校准等方面存在的计量难点和痛点问题，设计标准化、通用化的现场传递标准件和统型的计量适配器，并建立远程计量管控系统，以信息化平台为支撑，攻克远程自动在线计量大型系统级设备整体校准等难题，实现雷达TR生产线测试系统远程自动现场整体快速校准。     

基于运行成本优化的FADEC系统TLD分析

为了降低飞机限时派遣（TLD）的运行成本，提出了全权限数字式电子控制（FADEC）系统TLD分析的运行成本优化方 法。构建了TLD分析的典型马尔可夫模型，推导了该模型各状态稳态频度公式，从而建立了系统单位时间运行成本与派遣时间间 隔的函数关系，并以此作为运行成本优化的目标函数；推导了发动机控制系统平均安全性水平表达式，建立了平均安全性水平对 派遣时间间隔的约束。针对FADEC系统建立了3种不同的形式的系统单位时间运行成本函数模型，并提出了相应的派遣间隔决 策建议。结果表明：应用基于成本优化的FADEC系统TLD分析方法进行带故障派遣决策，能够在满足安全性要求的情况下，降低 飞机运行成本。     

Upregulation of erythropoietin receptor in UT-7/EPO cells inhibits simulated microgravity-induced cell apoptosis

Hematopoietic progenitor cell proliferation can be altered in either spaceflight or under simulated microgravity experiments on the ground, however, the underlying mechanism remains unknown. Our previous study showed that exposure of the human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO to conditions of simulated microgravity significantly inhibited the cellular proliferation rate and induced cell apoptosis. We postulated that the downregulation of the erythropoietin receptor (EPOR) expression in UT-7/EPO cells under simulated microgravity may be a possible reason for microgravity triggered apoptosis. In this paper, a human EPOR gene was transferred into UT-7/EPO cells and the resulting expression of EPOR on the surface of UT-7/EPO cells increased approximately 61% (p < 0.05) as selected by the antibiotic G418. It was also shown through cytometry assays and morphological observations that microgravity-induced apoptosis markedly decreased in these UT-7/EPO–EPOR cells. Thus, we concluded that upregulation of EPOR in UT-7/EPO cells could inhibit the simulated microgravity-induced cell apoptosis in this EPO dependent cell line.