X-ray induced alterations in the differentiation and mineralization potential of murine preosteoblastic cells

To evaluate the effects of ionizing radiation (IR) on murine preosteoblastic cell differentiation, we directed OCT-1 cells to the osteoblastic lineage by treatment with a combination of β-glycerophosphate (β-GP), ascorbic acid (AA), and dexamethasone (Dex). In vitro mineralization was evaluated based on histochemical staining and quantification of the hydroxyapatite content of the extracellular bone matrix. Expression of mRNA encoding Runx2, transforming growth factor β1 (TGF-β1), osteocalcin (OCN), and p21^CDKN1A was analyzed. Exposure to IR reduced the growth rate and diminished cell survival of OCT-1 cells under standard conditions. Notably, calcium content analysis revealed that deposition of mineralized matrix increased significantly under osteogenic conditions after X-ray exposure in a time-dependent manner. In this study, higher radiation doses exert significant overall effects on TGF-β1, OCN, and p21^CDKN1A gene expression, suggesting that gene expression following X-ray treatment is affected in a dose-dependent manner. Additionally, we verified that Runx2 was suppressed within 24 h after irradiation at 2 and 4 Gy. Although further studies are required to verify the molecular mechanism, our observations strongly suggest that treatment with IR markedly alters the differentiation and mineralization process of preosteoblastic cells.     

Solar cycle and latitude dependence of high-beta suprathermal plasma conditions in interplanetary space between 1.3 and 5.4 AU

The analysis of energetic particles and magnetic field measurements from the Ulysses spacecraft has shown that in a series of events, the energy density contained in the suprathermal tail particle distribution is comparable to or larger than that of the magnetic field, creating conditions of high-beta plasma. In this work we analyze periods of high-beta suprathermal plasma occurrences (β_ep > 1) in interplanetary space, using the ratio (β_ep) of the energetic particle (20 keV to ∼5 MeV) and magnetic field energy densities from measurements covering the entire Ulysses mission lifetime (1990–2009) in order to reveal new or to reconfirm some recently defined interesting characteristics. The main key-results of the work are summarized as follows: (i) we verify that high-beta events are detected within well identified regions corresponding mainly to the vicinity of shock surfaces and magnetic structures, and associated with energetic particle intensity enhancements due to (a) reacceleration at shock-fronts and (b) unusually large magnetic field depressions. (ii) We define three considerable features for the high-beta events, concentrated on the next points: (a) there is an appreciable solar-activity influence on the high-beta events, during the maximum and middle solar-cycle phase, (b) the annual peak magnitude and the number of occurrences of high events are well correlated with the sunspot number, (c) the high-beta suprathermal plasma events present a spatial distribution in heliographic latitudes (HL) up to ∼±80°, and a specific important concentration on the low (−25° ? HL < −6°, 6° < HL ? 25°) and median (−45° ? HL < −25°, 25° < HL ? 45°) latitudes. We also reconfirm by a statistical analysis the results of Marhavilas and Sarris (2011), that the high-beta suprathermal plasma (β_ep > 1) events are characterized by a very large parameter β_ep (up to 1732.5), a great total duration (406 days) and a large percentage of the Ulysses-mission lifetime (which is equal to 6.34% of the total duration with usable measurements, and 11.3% of the duration in presence of suprathermal particles events).     

Ion-acoustic waves in unmagnetized collisionless weakly relativistic plasma of warm-ion and isothermal-electron using time-fractional KdV equation

Collisionless unmagnetized plasma consisting of a mixture of warm ion-fluid and isothermal-electron is considered, assuming that the ion flow velocity has a weak relativistic effect. The reductive perturbation method has been employed to derive the Korteweg–de Vries (KdV) equation for small – but finite-amplitude electrostatic ion-acoustic waves in this plasma. The semi-inverse method and Agrawal’s method lead to the Euler–Lagrange equation that leads to the time fractional KdV equation. The variational-iteration method given by He is used to solve the derived time fractional KdV equation. The calculations show that the fractional order may play the same rule of higher order dissipation in KdV equation to modulate the soliton wave amplitude in the plasma system. The results of the present investigation may be applicable to some plasma environments, such as space-plasmas, laser-plasma interaction, plasma sheet boundary layer of the earth’s magnetosphere, solar atmosphere and interplanetary space.     

Comparison of Antarctic riometer radio wave absorption and THEMIS mission energetic electron fluxes

Simultaneous observations of in situ plasma properties in the tail of the Earth’s magnetosphere and of ground based instruments, lying on the same geomagnetic field lines, have recently proved to yield significant new results. In most cases magnetosphere ionosphere interactions during the night-time northern hemisphere conditions are studied. Here, observations of energetic electrons in the tail of the Earth’s magnetosphere made by the THEMIS mission satellites are compared with auroral radio wave absorption determined by riometers in the Antarctic for sunlit conditions. Days for which satellites and riometers are connected by the same geomagnetic field line are selected using a geomagnetic field model. The six days analysed show clear associations between fluxes and absorptions in some cases. However, these do not necessarily correspond to conjugacy intervals. Hours of positive associations are 1.65 times those for negative associations, all hours and days considered (1.42–3.6 on five days and 0.58 on the other day). These computations are assumed appropriate since the footprints of the satellites used approximately follow corrected geomagnetic parallels for all six days studied. The use of a finer parameterization of geomagnetic models to determine conjugacy may be needed.     

Future of Space Astronomy: A global Road Map for the next decades

The use of space techniques continues to play a key role in the advance of astrophysics by providing access to the entire electromagnetic spectrum from radio to high energy γ rays. The increasing size, complexity and cost of large space observatories places a growing emphasis on international collaboration. Furthermore, combining existing and future datasets from space and “ground based” observatories is an emerging mode of powerful and relatively inexpensive research to address problems that can only be tackled by the application of large multi-wavelength observations. While the present set of astronomical facilities is impressive and covers the entire electromagnetic spectrum, with complementary space and “ground based” telescopes, the situation in the next 10–20 years is of critical concern. The James Webb Space Telescope (JWST), to be launched not earlier than 2018, is the only approved future major space astronomy mission. Other major highly recommended space astronomy missions, such as the Wide-field Infrared Survey Telescope (WFIRST), the International X-ray Observatory (IXO), Large Interferometer Space Antenna (LISA) and the Space Infrared Telescope for Cosmology and Astrophysics (SPICA), have yet to be approved for development.     

Relativistic electron fluxes and dose rate variations during April–May 2010 geomagnetic disturbances in the R3DR data on ISS

Space radiation has been monitored successfully using the Radiation Risks Radiometer-Dosimeter (R3D) installed at the ESA EXPOSE-R (R3DR) facility outside of the Russian Zvezda module of the International Space Station (ISS) between March 2009 and January 2011. R3DR is a Liulin type spectrometer–dosimeter with a single Si PIN detector 2 cm² of area and 0.3 mm thick. The R3DR instrument accumulated about 2 million measurements of the absorbed dose rate and flux of 10 s resolution. The total external and internal shielding before the detector of R3DR device is 0.41 g cm⁻². The calculated stopping energy of normally incident particles to the detector is 0.78 MeV for electrons and 15.8 MeV for protons. After the Coronal Mass Ejection (CME) at 09:54 UTC on 3 April 2010, a shock was observed at the ACE spacecraft at 0756 UTC on 5 April, which led to a sudden impulse on Earth at 08:26 UTC. Nevertheless, while the magnetic substorms on 5 and 6 of April were moderate; the second largest in history of GOES fluence of electrons with energy >2 MeV was measured. The R3DR data show a relatively small amount of relativistic electrons on 5 April. The maximum dose rate of 2323 μGy day⁻¹ was reached on 7 April; by 9 April, a dose of 6600 μGy was accumulated. By the end of the period on 7 May 2010 a total dose of 11,587 μGy was absorbed. Our data were compared with AE-8 MIN, CRESS and ESA-SEE1 models using SPENVIS and with similar observations on American, Japanese and Russian satellites.     

A working hypothesis for connections between electrically-induced changes in cloud microphysics and storm vorticity,with possible effects on circulation

This paper outlines, and explores the uncertainties in, hypothesized connections between a series of processes that could explain two long-standing puzzles; those of (1) the observed winter storm vorticity responses to atmospheric energy inputs that change the ionosphere–earth current density, J_z, that appear to involve storm invigoration, and (2) changes in anti-cyclonic blocking and circulation that include the observed colder winters in Great Britain and western Europe at solar minima, and especially at extended solar minima. A working hypothesis for the mechanism responsible for (1) is that the flow of J_z through conductivity gradients, as in stratified cloud layers and fog, especially with sea-salt aerosol haze over the high latitude winter oceans, deposits electric changes on droplets and aerosol particles; most importantly on cloud condensation nuclei (CCN). These electric charges modulate scavenging of the particles in clouds and haze layers, increasing the concentration of small CCN and decreasing the concentration of large CCN. When further cloud formation occurs there is increased concentration of small droplets and decreased concentration of large ones, reducing coalescence and the production of rain. Thus updrafts carry more liquid water above the freezing level, and there the increased production of ice releases more latent heat and invigorates the updraft (the Rosenfeld mechanism), leading to increased vorticity. Here we explore the major uncertainties for the reality of the above chain of physical processes. A consequence of cumulative cyclonic vorticity increases is increases in downstream anti-cyclonic blocking. A further working hypothesis for (2) is that the invigoration may be large enough to contribute to the observed increases in blocking in winters at solar minima (high J_z) in the North Atlantic, that result in colder winters in the UK and northern Europe.     

Fast Probabilistic Particle Identification algorithm using silicon strip detectors

Active detectors used as radiation monitors in space are not usually able to perform Particle Identification (PID). Common techniques need energy loss spectra with high statistics to estimate ion abundances. The ALTEA-space detector system is a set of silicon strip particle telescopes monitoring the radiation environment on board the International Space Station since July 2006 with real-time telemetry capabilities. Its large geometrical factor due to the concurrent use of six detectors permits the acquisition of good energy loss spectra even in a short period of observation. In this paper we present a novel Fast Probabilistic Particle Identification (FPPI) algorithm developed for the ALTEA data analysis in order to perform nuclear identification with low statistics and, with some limitations, also in real time.     

An ion analyzer for the lunar surface with E-parallel–B

We present a novel instrument concept to measure the energy and mass spectra of ions incident on the lunar surface, based on the E-parallel–B or Thomson-parabola device used extensively as a diagnostic in the plasma fusion community. The Apollo-era Suprathermal Ion Detector Experiment (SIDE) was the first instrument package to perform in-situ measurements of ions incident on the lunar surface. The ions can originate from a variety of sources, including the solar wind, the Earth’s magnetotail, and photoionization of the thin lunar atmosphere. The species and energy distribution of ions arriving at the lunar surface depend in a complicated and poorly-understood fashion on the phase of the lunar day, the position of the Moon with respect to the Earth, and on the local plasma environment.     

Solar activity dependence of total electron content derived from GPS observations over Mbarara

Vertical total electron content (VTEC) observed at Mbarara (geographic co-ordinates: 0.60°S, 30.74°E; geomagnetic coordinates: 10.22°S, 102.36°E), Uganda, for the period 2001–2009 have been used to study the diurnal, seasonal and solar activity variations. The daily values of the 10.7 cm radio flux (F_10.7) and sunspot number (R) were used to represent Solar Extreme Ultraviolet Variability (EUV). VTEC is generally higher during high solar activity period for all the seasons and increases from 0600 h LT and reaches its maximum value within 1400 h–1500 h LT. All analysed linear and quadratic fits demonstrate positive VTEC-F_10.7 and positive VTEC-R correlation, with all fits at 0000 h and 1400 h LT being significant with a confidence level of 95% when both linear and quadratic models are used. All the fits at 0600 h LT are insignificant with a confidence level of 95%. Generally, over Mbarara, quadratic fit shows that VTEC saturates during all seasons for F_10.7 more than 200 units and R more than 150 units. The result of this study can be used to improve the International Reference Ionosphere (IRI) prediction of TEC around the equatorial region of the African sector.