A new perspective of carcinogenesis from protracted high-LET radiation arises from the two-stage clonal expansion model.

When applied to the Colorado Plateau miner population, the two-stage clonal expansion (TSCE) model of radiation carcinogenesis predicts that radiation-induced promotion dominates radiation-induced initiation. Thus, according to the model, at least for alpha-particle radiation from inhaled radon daughters, lung cancer induction over long periods of protracted irradiation appears to be dominated by radiation-induced modification of the proliferation kinetics of already-initiated cells rather than by direct radiation-induced initiation (i.e., mutation) of normal cells. We explore the possible consequences of this result for radiation exposures to space travelers on long missions. Still unknown is the LET dependence of this effect. Speculations of the cause of this phenomenon include the suggestion that modification of cell kinetics is caused by a "bystander" effect, i.e., the traversal of normal cells by alpha particles, followed by the signaling of these cells to nearby initiated cells which then modify their proliferation kinetics.     

Aspartic acid racemization and age-depth relationships for organic carbon in Siberian permafrost

We have analyzed the degree of racemization of aspartic acid in permafrost samples from Northern Siberia, an area from which microorganisms of apparent ages up to a few million years have previously been isolated and cultured. We find that the extent of aspartic acid racemization in permafrost cores increases very slowly up to an age of approximately 25,000 years (around 5 m in depth). The apparent temperature of racemization over the age range of 0-25,000 years, determined using measured aspartic acid racemization rate constants, is -19 degrees C. This apparent racemization temperature is significantly lower than the measured environmental temperature (-11 to -13 degrees C) and suggests active recycling of D-aspartic acid in Siberian permafrost up to an age of around 25,000 years. This indicates that permafrost organisms are capable of repairing some molecular damage incurred while in a "dormant" state over geologic time.     

Mass-independent fractionation of sulfur isotopes in Archean sediments: strong evidence for an anoxic Archean atmosphere

Mass-independent fractionation (MIF) of sulfur isotopes has been reported in sediments of Archean and Early Proterozoic Age (> 2.3 Ga) but not in younger rocks. The only fractionation mechanism that is consistent with the data on all four sulfur isotopes involves atmospheric photochemical reactions such as SO2 photolysis. We have used a one-dimensional photochemical model to investigate how the isotopic fractionation produced during SO2 photolysis would have been transferred to other gaseous and particulate sulfur-bearing species in both low-O2 and high-O2 atmospheres. We show that in atmospheres with O2 concentrations < 10(-5) times the present atmospheric level (PAL), sulfur would have been removed from the atmosphere in a variety of different oxidation states, each of which would have had its own distinct isotopic signature. By contrast, in atmospheres with O2 concentrations > or = 10(-5) PAL, all sulfur-bearing species would have passed through the oceanic sulfate reservoir before being incorporated into sediments, so any signature of MIF would have been lost. We conclude that the atmospheric O2 concentration must have been < 10(-5) PAL prior to 2.3 Ga.     

The image/poetry education and public outreach program

Education and public outreach are viewed by NASA as significant undertakings for all of its space missions. The IMAGE satellite is one of the first missions to explicitly include `E&PO in its original proposal to NASA in 1996. We will discuss what IMAGE has accomplished in this area to date, and what new activities it will conduct following a successful launch.     

Galactic Evolution of the Light Elements: A New Set of B Observations

The boron 2500 spectral region has been observed with the Goddard High Resolution Spectrograph (GHRS) of the Hubble Space Telescope (HST) in a new set of metal-poor stars and analyzed by spectrum synthesis technique, adopting the most recent model atmospheres. By taking into account the Li and Be abundances available from the literature for this same set of objects, the resulting patterns of their light elements abundances cannot be easily justified with the currently known stellar structure scenarios. The finding of real differences in the B content between stars with very similar stellar characteristics suggest that also production effects, rather than depletion and/or mixing only, should be taken into account as a possible and valuable explanation.     

Measurements of radiation exposure in civil aircraft

The radiation exposures on 12 flights of German airlines were measured with an active dosemeter based on two silicon semiconductors. The dependence on the date, altitude and route of the flights was studied. Measured dose rates and preliminary dose equivalent rates of the individual flights are given and compared with model calculations.     

The Kinelite Project: a new powerful motion analyser for Spacelab and space station

The goal of the Kinelite Project is to develop a space qualified motion analysis system to be used in space by the scientific community, mainly to support neuroscience protocols. The measurement principle of the Kinelite is to determine, by triangulation mean, the 3D position of small, lightweight, reflective markers positioned at the different points of interest. The scene is illuminated by Infra Red flashes and the reflected light is acquired by up to 8 precalibrated and synchronized CCD cameras. The main characteristics of the system are: Camera field of view: 45 degrees; Number of cameras: 2 to 8; Acquisition frequency: 25, 50, 100, or 200 Hz; CCD format: 256 x 256; Number of markers: up to 64; 3D accuracy: 2mm; Main dimensions: 45 cm x 45 cm x 30 cm; Mass: 23 kg; Power consumption: less than 200 W. The Kinelite will first fly aboard the NASA Spacelab; it will be used, during the NEUROLAB mission (4/98), to support the "Frames of References and Internal Models" (Principal Investigator: Pr. A. Berthoz, Co Investigators: J. McIntyre, F. Lacquaniti).     

Can Surface Flux Transport Account for the Weak Polar Field in Cycle 23?

To reproduce the weak magnetic field on the polar caps of the Sun observed during the declining phase of cycle 23 poses a challenge to surface flux transport models since this cycle has not been particularly weak. We use a well-calibrated model to evaluate the parameter changes required to obtain simulated polar fields and open flux that are consistent with the observations. We find that the low polar field of cycle 23 could be reproduced by an increase of the meridional flow by 55% in the last cycle. Alternatively, a decrease of the mean tilt angle of sunspot groups by 28% would also lead to a similarly low polar field, but cause a delay of the polar field reversals by 1.5 years in comparison to the observations.     

Vertical motions in Thailand after the 2004 Sumatra–Andaman Earthquake from GPS observations and its geophysical modelling

Following previous findings from ongoing GPS research in Thailand since 2004 we continue to exploit the GPS technique to monitor and model land motions induced by the Sumatra–Andaman Earthquake. Our latest results show that up to the end of 2010, Thailand has been co-seismically displaced and is subsequently undergoing a post-seismic horizontal deformation with total displacements (co-seismic plus post-seismic) ranging from 10.5 to 74.7 cm. We observed the largest horizontal displacements in the southern part of Thailand and moderate and small displacements in the central and northern parts. In addition to horizontal displacements throughout Thailand, continuous GPS measurements show that large parts of Thailand are subsiding at rates up to 1 cm/yr. It is the first time that such vertical post-seismic deformations at large distances (650–1500 km away from the Earthquake’s epicentre) have been recorded. We have investigated the physical processes leading to the observed subsidence. While after-slip on the subduction interface induces negligible or even slightly positive vertical motions, relaxation in the asthenosphere is associated with a sizable subsidence. Predictions from a 3D finite element model feature an asthenosphere with an effective viscosity of the order of 3 * 10¹⁸ Pas, fit the horizontal post-seismic data and the observed subsidence well. This model is then used to predict the subsidence over the whole seismic cycle. The subsidence should go on with a diminishing rate through the next two decades and its final magnitude should not exceed 10 cm in the Bangkok area.