A new model of the ion composition at 75 to 1000 km for IRI

Ion composition of the ionosphere is an important parameter of any ionospheric model. The International Reference Ionosphere-1979 includes a program for the relative ion composition computation. The program was constructed on the basis of the Danilov and Semenov /1/ empirical model, which averaged 42 rocket measurements of the ion composition at middle latitudes below 200 km, on “AEROS” satellite measurements, and on Taylor's data /2/ above that altitude.     

Application potential of SPOT imagery for topographic mapping

The high resolution and good geometric configuration possible with SPOT gives a high potential for the production of 1:100 000 topographic maps. Studies at University College London have investigated this potential with the aid of a simple instrument which will introduce the necessary corrections to level 1b photographic images and orthophotographs and allow stereoscopic viewing of SPOT images and the ability to compile a line map. Accuracy has been investigated by computing ground co-ordinates from image co-ordinates and pixel positions. The methods used and results obtained in this work are described.Work is now going on to investigate the use of digital image processors in the mapping procedures and the use of analytical plotting instruments, and comments on this work and on future developments are made.     

SAMBO-GEOS: On three-dimensional substorm dynamics — A case study for 4 March 1979

For investigations of the isolated magnetospheric substorm the ground-based and satellite geophysical data are discussed. The active phase of the substorm has two parts: an active-convective phase and a classical active phase. The analysed data show that the breakup of the substorm takes place at closed and not very much stretched magnetic field lines.     

Neoplastic cell transformation by high-LET radiation: molecular mechanisms.

Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a multi-step process [correction of processes], we know very little about the molecular nature of lesions important for cell transformation, the relationship between lethal and transformational damages, and the evolution of initial damages into final chromosomal aberrations which alter the growth control of cells. Using cultured mouse embryo cells (C3H10T1/2) as a model system, we have collected quantitative data on dose-response curves for heavy ions with various charges and energies. An analysis of these quantitative data suggested that two DNA breaks formed within 80 angstroms may cause cell transformation and that two DNA breaks formed within 20 angstroms may be lethal. Through studies with restriction enzymes which produce DNA damages at specific sites, we have found that DNA double strand breaks, including both blunt- and cohesive-ended breaks, can cause cell transformation in vitro. These results indicate that DNA double strand breaks can be important primary lesions for radiogenic cell transformation and that blunt-ended double strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship is similar for HGPRT gene mutation, chromosomal deletion, and cell transformation, suggesting common lesions may be involved in these radiation effects. The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells. At present the role of oncogenes in radiation cell transformation is unclear.     

The scientific case for renewed human activities on the Moon

It is over 30 years since the last human being stood on the lunar surface and this long hiatus in human exploration has been to the detriment of lunar and planetary science. The primary scientific importance of the Moon lies in the record it preserves of the early evolution of a terrestrial planet, and of the near-Earth cosmic environment in the first billion years or so of Solar System history. This record may not be preserved anywhere else; gaining proper access to it will require a human presence. Moreover, while this will primarily be a task for the geosciences, the astronomical and biological sciences would also benefit from a renewed human presence on the Moon, and especially from the establishment of a permanently occupied scientific outpost.     

The Exact Cramer-Rao Bound for Gaussian Autoregressive Processes

An explicit expression is derived for the Cramer-Rao bound(CRB)on unbiased estimates of the parameters of autoregressiveprocesses, given a finite number of measurements. The expressionconverges to the well-known asymptotic form of the CRB when thenumber of measurements tends to infinity. The behavior of thebound is illustrated by some numerical examples.     

Software intensive systems safety analysis

Two important elements in the avionics suite of modern aircraft are: the flight control system (FCS) and the flight management system (FMS). The FCS provides the capability to stabilize and control the aircraft, while the FMS is responsible for flight planning and navigation. A clear trend in the aerospace industry is to place greater reliance on software systems, and many FCS and FMS subsystems are implemented primarily in software. For example, within the FCS is the flight guidance system (FGS) that generates roll and pitch guidance commands. Similarly, within the FMS is the vertical navigation (VNAV) function that acts like a third crew member in the cockpit, ordering mode change requests and resetting target altitude values to enable the aircraft to track the vertical flight plan. We have developed formal, executable models of the requirements for the mode logic of a FGS and for portions of the VNAV functionality. We have also conducted a comprehensive software safety analysis on the FGS mode logic model, and are completing the analysis of the VNAV model. This analysis uses as its starting point several "traditional" safety analysis techniques such as a functional hazard assessment (FHA), a fault tree analysis (FTA), and a failure mode effects analysis (FMEA). However, we are also using formal methods techniques known as model checking and theorem proving to verify the presence of safety properties in the model. This paper summarizes the (now completed) safety analysis that was performed on the FGS model, and highlights the similarities and differences with the (still on-going) safety analysis of the FMS model. In particular, we summarize progress made to date in the use of formal methods to verify the presence of the required safety properties in the models themselves.     

Neoplastic transformation of hamster embryo cells by heavy ions

We have studied the induction of morphological transformation of Syrian hamster embryo cells by low doses of heavy ions with different linear energy transfer (LET), ranging from 13 to 400 keV/μm. Exponentially growing cells were irradiated with ¹²C or ²⁸Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), inoculated to culture dishes, and transformed colonies were identified when the cells were densely stacked and showed a crisscross pattern. Over the LET range examined, the frequency of transformation induced by the heavy ions increased sharply at very low doses no greater than 5 cGy. The relative biological effectiveness (RBE) of the heavy ions relative to 250 kVp X-rays showed an initial increase with LET, reaching a maximum value of about 7 at 100 keV/μm, and then decreased with the further increase in LET. Thus, we confirmed that high LET heavy ions are significantly more effective than X-rays for the induction of in vitro cell transformation.     

Space-borne technology and inversion techniques for radar

This presents recent progress of the state-of-the-art of space-borne radar technology in case of either earth-orbiting or planetary-orbiting satellites and space probes, respectively. In addition to that, recent progress is also discussed concerning specific inversion techniques to evaluate radar measurements; i.e., the art of deriving the relevant physical quantities to be determined such as terrain and depth profiles for planetary surface and/or subsurface structures ((3D)-profiles) from radar data measured depending on signal frequency, aspect angle, polarization, etc., as a function of time.     

Repair of DNA double-strand breaks and cell killing by charged particles.

It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS.